diff --git a/Dockerfiles/agent/README.md b/Dockerfiles/agent/README.md
index 9460c68b9..7d4c15f35 100644
--- a/Dockerfiles/agent/README.md
+++ b/Dockerfiles/agent/README.md
@@ -151,13 +151,18 @@ ZBX_UNSAFEUSERPARAMETERS=0
 ZBX_TLSCONNECT=unencrypted
 ZBX_TLSACCEPT=unencrypted
 ZBX_TLSCAFILE=
+ZBX_TLSCA=
 ZBX_TLSCRLFILE=
+ZBX_TLSCRL=
 ZBX_TLSSERVERCERTISSUER=
 ZBX_TLSSERVERCERTSUBJECT=
 ZBX_TLSCERTFILE=
+ZBX_TLSCERT=
 ZBX_TLSKEYFILE=
+ZBX_TLSKEY=
 ZBX_TLSPSKIDENTITY=
 ZBX_TLSPSKFILE=
+ZBX_TLSPSK=
 ZBX_TLSCIPHERALL= # Available since 4.4.7
 ZBX_TLSCIPHERALL13= # Available since 4.4.7
 ZBX_TLSCIPHERCERT= # Available since 4.4.7
@@ -186,7 +191,7 @@ The volume allows load additional modules and extend Zabbix agent using ``LoadMo
 
 ### ``/var/lib/zabbix/enc``
 
-The volume is used to store TLS related files. These file names are specified using ``ZBX_TLSCAFILE``, ``ZBX_TLSCRLFILE``, ``ZBX_TLSKEY_FILE`` and ``ZBX_TLSPSKFILE`` variables.
+The volume is used to store TLS related files. These file names are specified using ``ZBX_TLSCAFILE``, ``ZBX_TLSCRLFILE``, ``ZBX_TLSCERTFILE``, ``ZBX_TLSKEYFILE`` and ``ZBX_TLSPSKFILE`` variables. Additionally it is possible to use environment variables ``ZBX_TLSCA``, ``ZBX_TLSCRL``, ``ZBX_TLSCERT``, ``ZBX_TLSKEY`` and ``ZBX_TLSPSK`` with plaintext values.
 
 # The image variants
 
diff --git a/Dockerfiles/agent/alpine/Dockerfile b/Dockerfiles/agent/alpine/Dockerfile
index 3520fadc2..c7d84d807 100644
--- a/Dockerfiles/agent/alpine/Dockerfile
+++ b/Dockerfiles/agent/alpine/Dockerfile
@@ -63,6 +63,7 @@ RUN set -eux && \
     mkdir -p /etc/zabbix/zabbix_agentd.d && \
     mkdir -p /var/lib/zabbix && \
     mkdir -p /var/lib/zabbix/enc && \
+    mkdir -p /var/lib/zabbix/enc_internal && \
     mkdir -p /var/lib/zabbix/modules && \
     chown --quiet -R zabbix:root /etc/zabbix/ /var/lib/zabbix/ && \
     chgrp -R 0 /etc/zabbix/ /var/lib/zabbix/ && \
diff --git a/Dockerfiles/agent/alpine/docker-entrypoint.sh b/Dockerfiles/agent/alpine/docker-entrypoint.sh
index e2bcb52f1..c01f3ca19 100755
--- a/Dockerfiles/agent/alpine/docker-entrypoint.sh
+++ b/Dockerfiles/agent/alpine/docker-entrypoint.sh
@@ -20,6 +20,8 @@ fi
 ZABBIX_USER_HOME_DIR="/var/lib/zabbix"
 # Configuration files directory
 ZABBIX_ETC_DIR="/etc/zabbix"
+# Internal directory for TLS related files, used when TLS*File specified as plain text values
+ZABBIX_INTERNAL_ENC_DIR="${ZABBIX_USER_HOME_DIR}/enc_internal"
 
 escape_spec_char() {
     local var_value=$1
@@ -112,6 +114,19 @@ update_config_multiple_var() {
     done
 }
 
+file_process_from_env() {
+    local config_path=$1
+    local var_name=$2
+    local file_name=$3
+    local var_value=$4
+
+    if [ ! -z "$var_value" ]; then
+        echo -n "$var_value" > "${ZABBIX_INTERNAL_ENC_DIR}/$var_name"
+        file_name="${ZABBIX_INTERNAL_ENC_DIR}/${var_name}"
+    fi
+    update_config_var $config_path "$var_name" "$file_name"
+}
+
 prepare_zbx_agent_config() {
     echo "** Preparing Zabbix agent configuration file"
     ZBX_AGENT_CONFIG=$ZABBIX_ETC_DIR/zabbix_agentd.conf
@@ -176,20 +191,20 @@ prepare_zbx_agent_config() {
     update_config_multiple_var $ZBX_AGENT_CONFIG "LoadModule" "${ZBX_LOADMODULE}"
     update_config_var $ZBX_AGENT_CONFIG "TLSConnect" "${ZBX_TLSCONNECT}"
     update_config_var $ZBX_AGENT_CONFIG "TLSAccept" "${ZBX_TLSACCEPT}"
-    update_config_var $ZBX_AGENT_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}"
-    update_config_var $ZBX_AGENT_CONFIG "TLSCRLFile" "${ZBX_TLSCRLFILE}"
+    file_process_from_env $ZBX_AGENT_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}" "${ZBX_TLSCA}"
+    file_process_from_env $ZBX_AGENT_CONFIG "TLSCRLFile" "${ZBX_TLSCRLFILE}" "${ZBX_TLSCRL}"
     update_config_var $ZBX_AGENT_CONFIG "TLSServerCertIssuer" "${ZBX_TLSSERVERCERTISSUER}"
     update_config_var $ZBX_AGENT_CONFIG "TLSServerCertSubject" "${ZBX_TLSSERVERCERTSUBJECT}"
-    update_config_var $ZBX_AGENT_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}"
+    file_process_from_env $ZBX_AGENT_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}" "${ZBX_TLSCERT}"
     update_config_var $ZBX_AGENT_CONFIG "TLSCipherAll" "${ZBX_TLSCIPHERALL}"
     update_config_var $ZBX_AGENT_CONFIG "TLSCipherAll13" "${ZBX_TLSCIPHERALL13}"
     update_config_var $ZBX_AGENT_CONFIG "TLSCipherCert" "${ZBX_TLSCIPHERCERT}"
     update_config_var $ZBX_AGENT_CONFIG "TLSCipherCert13" "${ZBX_TLSCIPHERCERT13}"
     update_config_var $ZBX_AGENT_CONFIG "TLSCipherPSK" "${ZBX_TLSCIPHERPSK}"
     update_config_var $ZBX_AGENT_CONFIG "TLSCipherPSK13" "${ZBX_TLSCIPHERPSK13}"
-    update_config_var $ZBX_AGENT_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}"
+    file_process_from_env $ZBX_AGENT_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}" "${ZBX_TLSKEY}"
     update_config_var $ZBX_AGENT_CONFIG "TLSPSKIdentity" "${ZBX_TLSPSKIDENTITY}"
-    update_config_var $ZBX_AGENT_CONFIG "TLSPSKFile" "${ZBX_TLSPSKFILE}"
+    file_process_from_env $ZBX_AGENT_CONFIG "TLSPSKFile" "${ZBX_TLSPSKFILE}" "${ZBX_TLSPSK}"
 
     update_config_multiple_var $ZBX_AGENT_CONFIG "DenyKey" "${ZBX_DENYKEY}"
     update_config_multiple_var $ZBX_AGENT_CONFIG "AllowKey" "${ZBX_ALLOWKEY}"
diff --git a/Dockerfiles/agent/centos/Dockerfile b/Dockerfiles/agent/centos/Dockerfile
index 2db2dfb5c..34c413aa0 100644
--- a/Dockerfiles/agent/centos/Dockerfile
+++ b/Dockerfiles/agent/centos/Dockerfile
@@ -77,6 +77,7 @@ RUN --mount=type=tmpfs,target=/var/lib/dnf/ \
     mkdir -p /etc/zabbix/zabbix_agentd.d && \
     mkdir -p /var/lib/zabbix && \
     mkdir -p /var/lib/zabbix/enc && \
+    mkdir -p /var/lib/zabbix/enc_internal && \
     mkdir -p /var/lib/zabbix/modules && \
     chown --quiet -R zabbix:root /etc/zabbix/ /var/lib/zabbix/ && \
     chgrp -R 0 /etc/zabbix/ /var/lib/zabbix/ && \
diff --git a/Dockerfiles/agent/centos/docker-entrypoint.sh b/Dockerfiles/agent/centos/docker-entrypoint.sh
index e2bcb52f1..c01f3ca19 100755
--- a/Dockerfiles/agent/centos/docker-entrypoint.sh
+++ b/Dockerfiles/agent/centos/docker-entrypoint.sh
@@ -20,6 +20,8 @@ fi
 ZABBIX_USER_HOME_DIR="/var/lib/zabbix"
 # Configuration files directory
 ZABBIX_ETC_DIR="/etc/zabbix"
+# Internal directory for TLS related files, used when TLS*File specified as plain text values
+ZABBIX_INTERNAL_ENC_DIR="${ZABBIX_USER_HOME_DIR}/enc_internal"
 
 escape_spec_char() {
     local var_value=$1
@@ -112,6 +114,19 @@ update_config_multiple_var() {
     done
 }
 
+file_process_from_env() {
+    local config_path=$1
+    local var_name=$2
+    local file_name=$3
+    local var_value=$4
+
+    if [ ! -z "$var_value" ]; then
+        echo -n "$var_value" > "${ZABBIX_INTERNAL_ENC_DIR}/$var_name"
+        file_name="${ZABBIX_INTERNAL_ENC_DIR}/${var_name}"
+    fi
+    update_config_var $config_path "$var_name" "$file_name"
+}
+
 prepare_zbx_agent_config() {
     echo "** Preparing Zabbix agent configuration file"
     ZBX_AGENT_CONFIG=$ZABBIX_ETC_DIR/zabbix_agentd.conf
@@ -176,20 +191,20 @@ prepare_zbx_agent_config() {
     update_config_multiple_var $ZBX_AGENT_CONFIG "LoadModule" "${ZBX_LOADMODULE}"
     update_config_var $ZBX_AGENT_CONFIG "TLSConnect" "${ZBX_TLSCONNECT}"
     update_config_var $ZBX_AGENT_CONFIG "TLSAccept" "${ZBX_TLSACCEPT}"
-    update_config_var $ZBX_AGENT_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}"
-    update_config_var $ZBX_AGENT_CONFIG "TLSCRLFile" "${ZBX_TLSCRLFILE}"
+    file_process_from_env $ZBX_AGENT_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}" "${ZBX_TLSCA}"
+    file_process_from_env $ZBX_AGENT_CONFIG "TLSCRLFile" "${ZBX_TLSCRLFILE}" "${ZBX_TLSCRL}"
     update_config_var $ZBX_AGENT_CONFIG "TLSServerCertIssuer" "${ZBX_TLSSERVERCERTISSUER}"
     update_config_var $ZBX_AGENT_CONFIG "TLSServerCertSubject" "${ZBX_TLSSERVERCERTSUBJECT}"
-    update_config_var $ZBX_AGENT_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}"
+    file_process_from_env $ZBX_AGENT_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}" "${ZBX_TLSCERT}"
     update_config_var $ZBX_AGENT_CONFIG "TLSCipherAll" "${ZBX_TLSCIPHERALL}"
     update_config_var $ZBX_AGENT_CONFIG "TLSCipherAll13" "${ZBX_TLSCIPHERALL13}"
     update_config_var $ZBX_AGENT_CONFIG "TLSCipherCert" "${ZBX_TLSCIPHERCERT}"
     update_config_var $ZBX_AGENT_CONFIG "TLSCipherCert13" "${ZBX_TLSCIPHERCERT13}"
     update_config_var $ZBX_AGENT_CONFIG "TLSCipherPSK" "${ZBX_TLSCIPHERPSK}"
     update_config_var $ZBX_AGENT_CONFIG "TLSCipherPSK13" "${ZBX_TLSCIPHERPSK13}"
-    update_config_var $ZBX_AGENT_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}"
+    file_process_from_env $ZBX_AGENT_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}" "${ZBX_TLSKEY}"
     update_config_var $ZBX_AGENT_CONFIG "TLSPSKIdentity" "${ZBX_TLSPSKIDENTITY}"
-    update_config_var $ZBX_AGENT_CONFIG "TLSPSKFile" "${ZBX_TLSPSKFILE}"
+    file_process_from_env $ZBX_AGENT_CONFIG "TLSPSKFile" "${ZBX_TLSPSKFILE}" "${ZBX_TLSPSK}"
 
     update_config_multiple_var $ZBX_AGENT_CONFIG "DenyKey" "${ZBX_DENYKEY}"
     update_config_multiple_var $ZBX_AGENT_CONFIG "AllowKey" "${ZBX_ALLOWKEY}"
diff --git a/Dockerfiles/agent/ol/Dockerfile b/Dockerfiles/agent/ol/Dockerfile
index eb93998ae..8ccb66aa5 100644
--- a/Dockerfiles/agent/ol/Dockerfile
+++ b/Dockerfiles/agent/ol/Dockerfile
@@ -68,6 +68,7 @@ RUN --mount=type=tmpfs,target=/var/lib/dnf/ \
     mkdir -p /etc/zabbix/zabbix_agentd.d && \
     mkdir -p /var/lib/zabbix && \
     mkdir -p /var/lib/zabbix/enc && \
+    mkdir -p /var/lib/zabbix/enc_internal && \
     mkdir -p /var/lib/zabbix/modules && \
     chown --quiet -R zabbix:root /etc/zabbix/ /var/lib/zabbix/ && \
     chgrp -R 0 /etc/zabbix/ /var/lib/zabbix/ && \
diff --git a/Dockerfiles/agent/ol/docker-entrypoint.sh b/Dockerfiles/agent/ol/docker-entrypoint.sh
index e2bcb52f1..c01f3ca19 100755
--- a/Dockerfiles/agent/ol/docker-entrypoint.sh
+++ b/Dockerfiles/agent/ol/docker-entrypoint.sh
@@ -20,6 +20,8 @@ fi
 ZABBIX_USER_HOME_DIR="/var/lib/zabbix"
 # Configuration files directory
 ZABBIX_ETC_DIR="/etc/zabbix"
+# Internal directory for TLS related files, used when TLS*File specified as plain text values
+ZABBIX_INTERNAL_ENC_DIR="${ZABBIX_USER_HOME_DIR}/enc_internal"
 
 escape_spec_char() {
     local var_value=$1
@@ -112,6 +114,19 @@ update_config_multiple_var() {
     done
 }
 
+file_process_from_env() {
+    local config_path=$1
+    local var_name=$2
+    local file_name=$3
+    local var_value=$4
+
+    if [ ! -z "$var_value" ]; then
+        echo -n "$var_value" > "${ZABBIX_INTERNAL_ENC_DIR}/$var_name"
+        file_name="${ZABBIX_INTERNAL_ENC_DIR}/${var_name}"
+    fi
+    update_config_var $config_path "$var_name" "$file_name"
+}
+
 prepare_zbx_agent_config() {
     echo "** Preparing Zabbix agent configuration file"
     ZBX_AGENT_CONFIG=$ZABBIX_ETC_DIR/zabbix_agentd.conf
@@ -176,20 +191,20 @@ prepare_zbx_agent_config() {
     update_config_multiple_var $ZBX_AGENT_CONFIG "LoadModule" "${ZBX_LOADMODULE}"
     update_config_var $ZBX_AGENT_CONFIG "TLSConnect" "${ZBX_TLSCONNECT}"
     update_config_var $ZBX_AGENT_CONFIG "TLSAccept" "${ZBX_TLSACCEPT}"
-    update_config_var $ZBX_AGENT_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}"
-    update_config_var $ZBX_AGENT_CONFIG "TLSCRLFile" "${ZBX_TLSCRLFILE}"
+    file_process_from_env $ZBX_AGENT_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}" "${ZBX_TLSCA}"
+    file_process_from_env $ZBX_AGENT_CONFIG "TLSCRLFile" "${ZBX_TLSCRLFILE}" "${ZBX_TLSCRL}"
     update_config_var $ZBX_AGENT_CONFIG "TLSServerCertIssuer" "${ZBX_TLSSERVERCERTISSUER}"
     update_config_var $ZBX_AGENT_CONFIG "TLSServerCertSubject" "${ZBX_TLSSERVERCERTSUBJECT}"
-    update_config_var $ZBX_AGENT_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}"
+    file_process_from_env $ZBX_AGENT_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}" "${ZBX_TLSCERT}"
     update_config_var $ZBX_AGENT_CONFIG "TLSCipherAll" "${ZBX_TLSCIPHERALL}"
     update_config_var $ZBX_AGENT_CONFIG "TLSCipherAll13" "${ZBX_TLSCIPHERALL13}"
     update_config_var $ZBX_AGENT_CONFIG "TLSCipherCert" "${ZBX_TLSCIPHERCERT}"
     update_config_var $ZBX_AGENT_CONFIG "TLSCipherCert13" "${ZBX_TLSCIPHERCERT13}"
     update_config_var $ZBX_AGENT_CONFIG "TLSCipherPSK" "${ZBX_TLSCIPHERPSK}"
     update_config_var $ZBX_AGENT_CONFIG "TLSCipherPSK13" "${ZBX_TLSCIPHERPSK13}"
-    update_config_var $ZBX_AGENT_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}"
+    file_process_from_env $ZBX_AGENT_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}" "${ZBX_TLSKEY}"
     update_config_var $ZBX_AGENT_CONFIG "TLSPSKIdentity" "${ZBX_TLSPSKIDENTITY}"
-    update_config_var $ZBX_AGENT_CONFIG "TLSPSKFile" "${ZBX_TLSPSKFILE}"
+    file_process_from_env $ZBX_AGENT_CONFIG "TLSPSKFile" "${ZBX_TLSPSKFILE}" "${ZBX_TLSPSK}"
 
     update_config_multiple_var $ZBX_AGENT_CONFIG "DenyKey" "${ZBX_DENYKEY}"
     update_config_multiple_var $ZBX_AGENT_CONFIG "AllowKey" "${ZBX_ALLOWKEY}"
diff --git a/Dockerfiles/agent/rhel/Dockerfile b/Dockerfiles/agent/rhel/Dockerfile
index 32e59687d..a1f60d3aa 100644
--- a/Dockerfiles/agent/rhel/Dockerfile
+++ b/Dockerfiles/agent/rhel/Dockerfile
@@ -104,6 +104,7 @@ RUN --mount=type=tmpfs,target=/var/lib/dnf/ \
     mkdir -p /etc/zabbix/zabbix_agentd.d && \
     mkdir -p /var/lib/zabbix && \
     mkdir -p /var/lib/zabbix/enc && \
+    mkdir -p /var/lib/zabbix/enc_internal && \
     mkdir -p /var/lib/zabbix/modules && \
     chown --quiet -R zabbix:root /etc/zabbix/ /var/lib/zabbix/ && \
     chgrp -R 0 /etc/zabbix/ /var/lib/zabbix/ && \
diff --git a/Dockerfiles/agent/rhel/docker-entrypoint.sh b/Dockerfiles/agent/rhel/docker-entrypoint.sh
index e2bcb52f1..c01f3ca19 100755
--- a/Dockerfiles/agent/rhel/docker-entrypoint.sh
+++ b/Dockerfiles/agent/rhel/docker-entrypoint.sh
@@ -20,6 +20,8 @@ fi
 ZABBIX_USER_HOME_DIR="/var/lib/zabbix"
 # Configuration files directory
 ZABBIX_ETC_DIR="/etc/zabbix"
+# Internal directory for TLS related files, used when TLS*File specified as plain text values
+ZABBIX_INTERNAL_ENC_DIR="${ZABBIX_USER_HOME_DIR}/enc_internal"
 
 escape_spec_char() {
     local var_value=$1
@@ -112,6 +114,19 @@ update_config_multiple_var() {
     done
 }
 
+file_process_from_env() {
+    local config_path=$1
+    local var_name=$2
+    local file_name=$3
+    local var_value=$4
+
+    if [ ! -z "$var_value" ]; then
+        echo -n "$var_value" > "${ZABBIX_INTERNAL_ENC_DIR}/$var_name"
+        file_name="${ZABBIX_INTERNAL_ENC_DIR}/${var_name}"
+    fi
+    update_config_var $config_path "$var_name" "$file_name"
+}
+
 prepare_zbx_agent_config() {
     echo "** Preparing Zabbix agent configuration file"
     ZBX_AGENT_CONFIG=$ZABBIX_ETC_DIR/zabbix_agentd.conf
@@ -176,20 +191,20 @@ prepare_zbx_agent_config() {
     update_config_multiple_var $ZBX_AGENT_CONFIG "LoadModule" "${ZBX_LOADMODULE}"
     update_config_var $ZBX_AGENT_CONFIG "TLSConnect" "${ZBX_TLSCONNECT}"
     update_config_var $ZBX_AGENT_CONFIG "TLSAccept" "${ZBX_TLSACCEPT}"
-    update_config_var $ZBX_AGENT_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}"
-    update_config_var $ZBX_AGENT_CONFIG "TLSCRLFile" "${ZBX_TLSCRLFILE}"
+    file_process_from_env $ZBX_AGENT_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}" "${ZBX_TLSCA}"
+    file_process_from_env $ZBX_AGENT_CONFIG "TLSCRLFile" "${ZBX_TLSCRLFILE}" "${ZBX_TLSCRL}"
     update_config_var $ZBX_AGENT_CONFIG "TLSServerCertIssuer" "${ZBX_TLSSERVERCERTISSUER}"
     update_config_var $ZBX_AGENT_CONFIG "TLSServerCertSubject" "${ZBX_TLSSERVERCERTSUBJECT}"
-    update_config_var $ZBX_AGENT_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}"
+    file_process_from_env $ZBX_AGENT_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}" "${ZBX_TLSCERT}"
     update_config_var $ZBX_AGENT_CONFIG "TLSCipherAll" "${ZBX_TLSCIPHERALL}"
     update_config_var $ZBX_AGENT_CONFIG "TLSCipherAll13" "${ZBX_TLSCIPHERALL13}"
     update_config_var $ZBX_AGENT_CONFIG "TLSCipherCert" "${ZBX_TLSCIPHERCERT}"
     update_config_var $ZBX_AGENT_CONFIG "TLSCipherCert13" "${ZBX_TLSCIPHERCERT13}"
     update_config_var $ZBX_AGENT_CONFIG "TLSCipherPSK" "${ZBX_TLSCIPHERPSK}"
     update_config_var $ZBX_AGENT_CONFIG "TLSCipherPSK13" "${ZBX_TLSCIPHERPSK13}"
-    update_config_var $ZBX_AGENT_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}"
+    file_process_from_env $ZBX_AGENT_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}" "${ZBX_TLSKEY}"
     update_config_var $ZBX_AGENT_CONFIG "TLSPSKIdentity" "${ZBX_TLSPSKIDENTITY}"
-    update_config_var $ZBX_AGENT_CONFIG "TLSPSKFile" "${ZBX_TLSPSKFILE}"
+    file_process_from_env $ZBX_AGENT_CONFIG "TLSPSKFile" "${ZBX_TLSPSKFILE}" "${ZBX_TLSPSK}"
 
     update_config_multiple_var $ZBX_AGENT_CONFIG "DenyKey" "${ZBX_DENYKEY}"
     update_config_multiple_var $ZBX_AGENT_CONFIG "AllowKey" "${ZBX_ALLOWKEY}"
diff --git a/Dockerfiles/agent/ubuntu/Dockerfile b/Dockerfiles/agent/ubuntu/Dockerfile
index 9f902f637..bf7cc88d4 100644
--- a/Dockerfiles/agent/ubuntu/Dockerfile
+++ b/Dockerfiles/agent/ubuntu/Dockerfile
@@ -63,6 +63,7 @@ RUN --mount=type=cache,target=/var/lib/apt/,sharing=locked \
     mkdir -p /etc/zabbix/zabbix_agentd.d && \
     mkdir -p /var/lib/zabbix && \
     mkdir -p /var/lib/zabbix/enc && \
+    mkdir -p /var/lib/zabbix/enc_internal && \
     mkdir -p /var/lib/zabbix/modules && \
     chown --quiet -R zabbix:root /etc/zabbix/ /var/lib/zabbix/ && \
     chgrp -R 0 /etc/zabbix/ /var/lib/zabbix/ && \
diff --git a/Dockerfiles/agent/ubuntu/docker-entrypoint.sh b/Dockerfiles/agent/ubuntu/docker-entrypoint.sh
index e2bcb52f1..c01f3ca19 100755
--- a/Dockerfiles/agent/ubuntu/docker-entrypoint.sh
+++ b/Dockerfiles/agent/ubuntu/docker-entrypoint.sh
@@ -20,6 +20,8 @@ fi
 ZABBIX_USER_HOME_DIR="/var/lib/zabbix"
 # Configuration files directory
 ZABBIX_ETC_DIR="/etc/zabbix"
+# Internal directory for TLS related files, used when TLS*File specified as plain text values
+ZABBIX_INTERNAL_ENC_DIR="${ZABBIX_USER_HOME_DIR}/enc_internal"
 
 escape_spec_char() {
     local var_value=$1
@@ -112,6 +114,19 @@ update_config_multiple_var() {
     done
 }
 
+file_process_from_env() {
+    local config_path=$1
+    local var_name=$2
+    local file_name=$3
+    local var_value=$4
+
+    if [ ! -z "$var_value" ]; then
+        echo -n "$var_value" > "${ZABBIX_INTERNAL_ENC_DIR}/$var_name"
+        file_name="${ZABBIX_INTERNAL_ENC_DIR}/${var_name}"
+    fi
+    update_config_var $config_path "$var_name" "$file_name"
+}
+
 prepare_zbx_agent_config() {
     echo "** Preparing Zabbix agent configuration file"
     ZBX_AGENT_CONFIG=$ZABBIX_ETC_DIR/zabbix_agentd.conf
@@ -176,20 +191,20 @@ prepare_zbx_agent_config() {
     update_config_multiple_var $ZBX_AGENT_CONFIG "LoadModule" "${ZBX_LOADMODULE}"
     update_config_var $ZBX_AGENT_CONFIG "TLSConnect" "${ZBX_TLSCONNECT}"
     update_config_var $ZBX_AGENT_CONFIG "TLSAccept" "${ZBX_TLSACCEPT}"
-    update_config_var $ZBX_AGENT_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}"
-    update_config_var $ZBX_AGENT_CONFIG "TLSCRLFile" "${ZBX_TLSCRLFILE}"
+    file_process_from_env $ZBX_AGENT_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}" "${ZBX_TLSCA}"
+    file_process_from_env $ZBX_AGENT_CONFIG "TLSCRLFile" "${ZBX_TLSCRLFILE}" "${ZBX_TLSCRL}"
     update_config_var $ZBX_AGENT_CONFIG "TLSServerCertIssuer" "${ZBX_TLSSERVERCERTISSUER}"
     update_config_var $ZBX_AGENT_CONFIG "TLSServerCertSubject" "${ZBX_TLSSERVERCERTSUBJECT}"
-    update_config_var $ZBX_AGENT_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}"
+    file_process_from_env $ZBX_AGENT_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}" "${ZBX_TLSCERT}"
     update_config_var $ZBX_AGENT_CONFIG "TLSCipherAll" "${ZBX_TLSCIPHERALL}"
     update_config_var $ZBX_AGENT_CONFIG "TLSCipherAll13" "${ZBX_TLSCIPHERALL13}"
     update_config_var $ZBX_AGENT_CONFIG "TLSCipherCert" "${ZBX_TLSCIPHERCERT}"
     update_config_var $ZBX_AGENT_CONFIG "TLSCipherCert13" "${ZBX_TLSCIPHERCERT13}"
     update_config_var $ZBX_AGENT_CONFIG "TLSCipherPSK" "${ZBX_TLSCIPHERPSK}"
     update_config_var $ZBX_AGENT_CONFIG "TLSCipherPSK13" "${ZBX_TLSCIPHERPSK13}"
-    update_config_var $ZBX_AGENT_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}"
+    file_process_from_env $ZBX_AGENT_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}" "${ZBX_TLSKEY}"
     update_config_var $ZBX_AGENT_CONFIG "TLSPSKIdentity" "${ZBX_TLSPSKIDENTITY}"
-    update_config_var $ZBX_AGENT_CONFIG "TLSPSKFile" "${ZBX_TLSPSKFILE}"
+    file_process_from_env $ZBX_AGENT_CONFIG "TLSPSKFile" "${ZBX_TLSPSKFILE}" "${ZBX_TLSPSK}"
 
     update_config_multiple_var $ZBX_AGENT_CONFIG "DenyKey" "${ZBX_DENYKEY}"
     update_config_multiple_var $ZBX_AGENT_CONFIG "AllowKey" "${ZBX_ALLOWKEY}"
diff --git a/Dockerfiles/agent2/README.md b/Dockerfiles/agent2/README.md
index 0f66e44a3..07f97b0bc 100644
--- a/Dockerfiles/agent2/README.md
+++ b/Dockerfiles/agent2/README.md
@@ -147,13 +147,18 @@ ZBX_UNSAFEUSERPARAMETERS=0
 ZBX_TLSCONNECT=unencrypted
 ZBX_TLSACCEPT=unencrypted
 ZBX_TLSCAFILE=
+ZBX_TLSCA=
 ZBX_TLSCRLFILE=
+ZBX_TLSCRL=
 ZBX_TLSSERVERCERTISSUER=
 ZBX_TLSSERVERCERTSUBJECT=
 ZBX_TLSCERTFILE=
+ZBX_TLSCERT=
 ZBX_TLSKEYFILE=
+ZBX_TLSKEY=
 ZBX_TLSPSKIDENTITY=
 ZBX_TLSPSKFILE=
+ZBX_TLSPSK=
 ZBX_DENYKEY=system.run[*] # Available since 5.0.0
 ZBX_ALLOWKEY= # Available since 5.0.0
 ```
@@ -172,7 +177,7 @@ The volume allows include ``*.conf`` files and extend Zabbix agent 2 using ``Use
 
 ### ``/var/lib/zabbix/enc``
 
-The volume is used to store TLS related files. These file names are specified using ``ZBX_TLSCAFILE``, ``ZBX_TLSCRLFILE``, ``ZBX_TLSKEY_FILE`` and ``ZBX_TLSPSKFILE`` variables.
+The volume is used to store TLS related files. These file names are specified using ``ZBX_TLSCAFILE``, ``ZBX_TLSCRLFILE``, ``ZBX_TLSCERTFILE``, ``ZBX_TLSKEYFILE`` and ``ZBX_TLSPSKFILE`` variables. Additionally it is possible to use environment variables ``ZBX_TLSCA``, ``ZBX_TLSCRL``, ``ZBX_TLSCERT``, ``ZBX_TLSKEY`` and ``ZBX_TLSPSK`` with plaintext values.
 
 ### ``/var/lib/zabbix/buffer``
 
diff --git a/Dockerfiles/agent2/alpine/Dockerfile b/Dockerfiles/agent2/alpine/Dockerfile
index 0241f6838..8aefa9dc2 100644
--- a/Dockerfiles/agent2/alpine/Dockerfile
+++ b/Dockerfiles/agent2/alpine/Dockerfile
@@ -61,6 +61,7 @@ RUN set -eux && \
     mkdir -p /etc/zabbix/zabbix_agentd.d && \
     mkdir -p /var/lib/zabbix && \
     mkdir -p /var/lib/zabbix/enc && \
+    mkdir -p /var/lib/zabbix/enc_internal && \
     mkdir -p /var/lib/zabbix/modules && \
     mkdir -p /var/lib/zabbix/buffer && \
     chown --quiet -R zabbix:root /etc/zabbix/ /var/lib/zabbix/ /usr/sbin/zabbix-agent2-plugin/ && \
diff --git a/Dockerfiles/agent2/alpine/docker-entrypoint.sh b/Dockerfiles/agent2/alpine/docker-entrypoint.sh
index 904af68d6..925e8c59d 100755
--- a/Dockerfiles/agent2/alpine/docker-entrypoint.sh
+++ b/Dockerfiles/agent2/alpine/docker-entrypoint.sh
@@ -20,6 +20,8 @@ fi
 ZABBIX_USER_HOME_DIR="/var/lib/zabbix"
 # Configuration files directory
 ZABBIX_ETC_DIR="/etc/zabbix"
+# Internal directory for TLS related files, used when TLS*File specified as plain text values
+ZABBIX_INTERNAL_ENC_DIR="${ZABBIX_USER_HOME_DIR}/enc_internal"
 
 escape_spec_char() {
     local var_value=$1
@@ -112,6 +114,19 @@ update_config_multiple_var() {
     done
 }
 
+file_process_from_env() {
+    local config_path=$1
+    local var_name=$2
+    local file_name=$3
+    local var_value=$4
+
+    if [ ! -z "$var_value" ]; then
+        echo -n "$var_value" > "${ZABBIX_INTERNAL_ENC_DIR}/$var_name"
+        file_name="${ZABBIX_INTERNAL_ENC_DIR}/${var_name}"
+    fi
+    update_config_var $config_path "$var_name" "$file_name"
+}
+
 prepare_zbx_agent_config() {
     echo "** Preparing Zabbix agent configuration file"
     ZBX_AGENT_CONFIG=$ZABBIX_ETC_DIR/zabbix_agent2.conf
@@ -185,14 +200,14 @@ prepare_zbx_agent_config() {
     update_config_var $ZBX_AGENT_CONFIG "UnsafeUserParameters" "${ZBX_UNSAFEUSERPARAMETERS}"
     update_config_var $ZBX_AGENT_CONFIG "TLSConnect" "${ZBX_TLSCONNECT}"
     update_config_var $ZBX_AGENT_CONFIG "TLSAccept" "${ZBX_TLSACCEPT}"
-    update_config_var $ZBX_AGENT_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}"
-    update_config_var $ZBX_AGENT_CONFIG "TLSCRLFile" "${ZBX_TLSCRLFILE}"
+    file_process_from_env $ZBX_AGENT_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}" "${ZBX_TLSCA}"
+    file_process_from_env $ZBX_AGENT_CONFIG "TLSCRLFile" "${ZBX_TLSCRLFILE}" "${ZBX_TLSCRL}"
     update_config_var $ZBX_AGENT_CONFIG "TLSServerCertIssuer" "${ZBX_TLSSERVERCERTISSUER}"
     update_config_var $ZBX_AGENT_CONFIG "TLSServerCertSubject" "${ZBX_TLSSERVERCERTSUBJECT}"
-    update_config_var $ZBX_AGENT_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}"
-    update_config_var $ZBX_AGENT_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}"
+    file_process_from_env $ZBX_AGENT_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}" "${ZBX_TLSCERT}"
+    file_process_from_env $ZBX_AGENT_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}" "${ZBX_TLSKEY}"
     update_config_var $ZBX_AGENT_CONFIG "TLSPSKIdentity" "${ZBX_TLSPSKIDENTITY}"
-    update_config_var $ZBX_AGENT_CONFIG "TLSPSKFile" "${ZBX_TLSPSKFILE}"
+    file_process_from_env $ZBX_AGENT_CONFIG "TLSPSKFile" "${ZBX_TLSPSKFILE}" "${ZBX_TLSPSK}"
 
     update_config_multiple_var $ZBX_AGENT_CONFIG "DenyKey" "${ZBX_DENYKEY}"
     update_config_multiple_var $ZBX_AGENT_CONFIG "AllowKey" "${ZBX_ALLOWKEY}"
diff --git a/Dockerfiles/agent2/centos/Dockerfile b/Dockerfiles/agent2/centos/Dockerfile
index 870808f16..07fdb0a02 100644
--- a/Dockerfiles/agent2/centos/Dockerfile
+++ b/Dockerfiles/agent2/centos/Dockerfile
@@ -79,6 +79,7 @@ RUN --mount=type=tmpfs,target=/var/lib/dnf/ \
     mkdir -p /etc/zabbix/zabbix_agentd.d && \
     mkdir -p /var/lib/zabbix && \
     mkdir -p /var/lib/zabbix/enc && \
+    mkdir -p /var/lib/zabbix/enc_internal && \
     mkdir -p /var/lib/zabbix/modules && \
     mkdir -p /var/lib/zabbix/buffer && \
     chown --quiet -R zabbix:root /etc/zabbix/ /var/lib/zabbix/ /usr/sbin/zabbix-agent2-plugin/ && \
diff --git a/Dockerfiles/agent2/centos/docker-entrypoint.sh b/Dockerfiles/agent2/centos/docker-entrypoint.sh
index 904af68d6..925e8c59d 100755
--- a/Dockerfiles/agent2/centos/docker-entrypoint.sh
+++ b/Dockerfiles/agent2/centos/docker-entrypoint.sh
@@ -20,6 +20,8 @@ fi
 ZABBIX_USER_HOME_DIR="/var/lib/zabbix"
 # Configuration files directory
 ZABBIX_ETC_DIR="/etc/zabbix"
+# Internal directory for TLS related files, used when TLS*File specified as plain text values
+ZABBIX_INTERNAL_ENC_DIR="${ZABBIX_USER_HOME_DIR}/enc_internal"
 
 escape_spec_char() {
     local var_value=$1
@@ -112,6 +114,19 @@ update_config_multiple_var() {
     done
 }
 
+file_process_from_env() {
+    local config_path=$1
+    local var_name=$2
+    local file_name=$3
+    local var_value=$4
+
+    if [ ! -z "$var_value" ]; then
+        echo -n "$var_value" > "${ZABBIX_INTERNAL_ENC_DIR}/$var_name"
+        file_name="${ZABBIX_INTERNAL_ENC_DIR}/${var_name}"
+    fi
+    update_config_var $config_path "$var_name" "$file_name"
+}
+
 prepare_zbx_agent_config() {
     echo "** Preparing Zabbix agent configuration file"
     ZBX_AGENT_CONFIG=$ZABBIX_ETC_DIR/zabbix_agent2.conf
@@ -185,14 +200,14 @@ prepare_zbx_agent_config() {
     update_config_var $ZBX_AGENT_CONFIG "UnsafeUserParameters" "${ZBX_UNSAFEUSERPARAMETERS}"
     update_config_var $ZBX_AGENT_CONFIG "TLSConnect" "${ZBX_TLSCONNECT}"
     update_config_var $ZBX_AGENT_CONFIG "TLSAccept" "${ZBX_TLSACCEPT}"
-    update_config_var $ZBX_AGENT_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}"
-    update_config_var $ZBX_AGENT_CONFIG "TLSCRLFile" "${ZBX_TLSCRLFILE}"
+    file_process_from_env $ZBX_AGENT_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}" "${ZBX_TLSCA}"
+    file_process_from_env $ZBX_AGENT_CONFIG "TLSCRLFile" "${ZBX_TLSCRLFILE}" "${ZBX_TLSCRL}"
     update_config_var $ZBX_AGENT_CONFIG "TLSServerCertIssuer" "${ZBX_TLSSERVERCERTISSUER}"
     update_config_var $ZBX_AGENT_CONFIG "TLSServerCertSubject" "${ZBX_TLSSERVERCERTSUBJECT}"
-    update_config_var $ZBX_AGENT_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}"
-    update_config_var $ZBX_AGENT_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}"
+    file_process_from_env $ZBX_AGENT_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}" "${ZBX_TLSCERT}"
+    file_process_from_env $ZBX_AGENT_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}" "${ZBX_TLSKEY}"
     update_config_var $ZBX_AGENT_CONFIG "TLSPSKIdentity" "${ZBX_TLSPSKIDENTITY}"
-    update_config_var $ZBX_AGENT_CONFIG "TLSPSKFile" "${ZBX_TLSPSKFILE}"
+    file_process_from_env $ZBX_AGENT_CONFIG "TLSPSKFile" "${ZBX_TLSPSKFILE}" "${ZBX_TLSPSK}"
 
     update_config_multiple_var $ZBX_AGENT_CONFIG "DenyKey" "${ZBX_DENYKEY}"
     update_config_multiple_var $ZBX_AGENT_CONFIG "AllowKey" "${ZBX_ALLOWKEY}"
diff --git a/Dockerfiles/agent2/ol/Dockerfile b/Dockerfiles/agent2/ol/Dockerfile
index e914c14dc..be80e62a7 100644
--- a/Dockerfiles/agent2/ol/Dockerfile
+++ b/Dockerfiles/agent2/ol/Dockerfile
@@ -69,6 +69,7 @@ RUN --mount=type=tmpfs,target=/var/lib/dnf/ \
     mkdir -p /etc/zabbix/zabbix_agentd.d && \
     mkdir -p /var/lib/zabbix && \
     mkdir -p /var/lib/zabbix/enc && \
+    mkdir -p /var/lib/zabbix/enc_internal && \
     mkdir -p /var/lib/zabbix/modules && \
     mkdir -p /var/lib/zabbix/buffer && \
     chown --quiet -R zabbix:root /etc/zabbix/ /var/lib/zabbix/ /usr/sbin/zabbix-agent2-plugin/ && \
diff --git a/Dockerfiles/agent2/ol/docker-entrypoint.sh b/Dockerfiles/agent2/ol/docker-entrypoint.sh
index 904af68d6..925e8c59d 100755
--- a/Dockerfiles/agent2/ol/docker-entrypoint.sh
+++ b/Dockerfiles/agent2/ol/docker-entrypoint.sh
@@ -20,6 +20,8 @@ fi
 ZABBIX_USER_HOME_DIR="/var/lib/zabbix"
 # Configuration files directory
 ZABBIX_ETC_DIR="/etc/zabbix"
+# Internal directory for TLS related files, used when TLS*File specified as plain text values
+ZABBIX_INTERNAL_ENC_DIR="${ZABBIX_USER_HOME_DIR}/enc_internal"
 
 escape_spec_char() {
     local var_value=$1
@@ -112,6 +114,19 @@ update_config_multiple_var() {
     done
 }
 
+file_process_from_env() {
+    local config_path=$1
+    local var_name=$2
+    local file_name=$3
+    local var_value=$4
+
+    if [ ! -z "$var_value" ]; then
+        echo -n "$var_value" > "${ZABBIX_INTERNAL_ENC_DIR}/$var_name"
+        file_name="${ZABBIX_INTERNAL_ENC_DIR}/${var_name}"
+    fi
+    update_config_var $config_path "$var_name" "$file_name"
+}
+
 prepare_zbx_agent_config() {
     echo "** Preparing Zabbix agent configuration file"
     ZBX_AGENT_CONFIG=$ZABBIX_ETC_DIR/zabbix_agent2.conf
@@ -185,14 +200,14 @@ prepare_zbx_agent_config() {
     update_config_var $ZBX_AGENT_CONFIG "UnsafeUserParameters" "${ZBX_UNSAFEUSERPARAMETERS}"
     update_config_var $ZBX_AGENT_CONFIG "TLSConnect" "${ZBX_TLSCONNECT}"
     update_config_var $ZBX_AGENT_CONFIG "TLSAccept" "${ZBX_TLSACCEPT}"
-    update_config_var $ZBX_AGENT_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}"
-    update_config_var $ZBX_AGENT_CONFIG "TLSCRLFile" "${ZBX_TLSCRLFILE}"
+    file_process_from_env $ZBX_AGENT_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}" "${ZBX_TLSCA}"
+    file_process_from_env $ZBX_AGENT_CONFIG "TLSCRLFile" "${ZBX_TLSCRLFILE}" "${ZBX_TLSCRL}"
     update_config_var $ZBX_AGENT_CONFIG "TLSServerCertIssuer" "${ZBX_TLSSERVERCERTISSUER}"
     update_config_var $ZBX_AGENT_CONFIG "TLSServerCertSubject" "${ZBX_TLSSERVERCERTSUBJECT}"
-    update_config_var $ZBX_AGENT_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}"
-    update_config_var $ZBX_AGENT_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}"
+    file_process_from_env $ZBX_AGENT_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}" "${ZBX_TLSCERT}"
+    file_process_from_env $ZBX_AGENT_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}" "${ZBX_TLSKEY}"
     update_config_var $ZBX_AGENT_CONFIG "TLSPSKIdentity" "${ZBX_TLSPSKIDENTITY}"
-    update_config_var $ZBX_AGENT_CONFIG "TLSPSKFile" "${ZBX_TLSPSKFILE}"
+    file_process_from_env $ZBX_AGENT_CONFIG "TLSPSKFile" "${ZBX_TLSPSKFILE}" "${ZBX_TLSPSK}"
 
     update_config_multiple_var $ZBX_AGENT_CONFIG "DenyKey" "${ZBX_DENYKEY}"
     update_config_multiple_var $ZBX_AGENT_CONFIG "AllowKey" "${ZBX_ALLOWKEY}"
diff --git a/Dockerfiles/agent2/rhel/Dockerfile b/Dockerfiles/agent2/rhel/Dockerfile
index 5de6a8e77..5ed2ed35e 100644
--- a/Dockerfiles/agent2/rhel/Dockerfile
+++ b/Dockerfiles/agent2/rhel/Dockerfile
@@ -105,6 +105,7 @@ RUN --mount=type=tmpfs,target=/var/lib/dnf/ \
     mkdir -p /etc/zabbix/zabbix_agentd.d && \
     mkdir -p /var/lib/zabbix && \
     mkdir -p /var/lib/zabbix/enc && \
+    mkdir -p /var/lib/zabbix/enc_internal && \
     mkdir -p /var/lib/zabbix/modules && \
     mkdir -p /var/lib/zabbix/buffer && \
     chown --quiet -R zabbix:root /etc/zabbix/ /var/lib/zabbix/ /usr/sbin/zabbix-agent2-plugin/ && \
diff --git a/Dockerfiles/agent2/rhel/docker-entrypoint.sh b/Dockerfiles/agent2/rhel/docker-entrypoint.sh
index 904af68d6..925e8c59d 100755
--- a/Dockerfiles/agent2/rhel/docker-entrypoint.sh
+++ b/Dockerfiles/agent2/rhel/docker-entrypoint.sh
@@ -20,6 +20,8 @@ fi
 ZABBIX_USER_HOME_DIR="/var/lib/zabbix"
 # Configuration files directory
 ZABBIX_ETC_DIR="/etc/zabbix"
+# Internal directory for TLS related files, used when TLS*File specified as plain text values
+ZABBIX_INTERNAL_ENC_DIR="${ZABBIX_USER_HOME_DIR}/enc_internal"
 
 escape_spec_char() {
     local var_value=$1
@@ -112,6 +114,19 @@ update_config_multiple_var() {
     done
 }
 
+file_process_from_env() {
+    local config_path=$1
+    local var_name=$2
+    local file_name=$3
+    local var_value=$4
+
+    if [ ! -z "$var_value" ]; then
+        echo -n "$var_value" > "${ZABBIX_INTERNAL_ENC_DIR}/$var_name"
+        file_name="${ZABBIX_INTERNAL_ENC_DIR}/${var_name}"
+    fi
+    update_config_var $config_path "$var_name" "$file_name"
+}
+
 prepare_zbx_agent_config() {
     echo "** Preparing Zabbix agent configuration file"
     ZBX_AGENT_CONFIG=$ZABBIX_ETC_DIR/zabbix_agent2.conf
@@ -185,14 +200,14 @@ prepare_zbx_agent_config() {
     update_config_var $ZBX_AGENT_CONFIG "UnsafeUserParameters" "${ZBX_UNSAFEUSERPARAMETERS}"
     update_config_var $ZBX_AGENT_CONFIG "TLSConnect" "${ZBX_TLSCONNECT}"
     update_config_var $ZBX_AGENT_CONFIG "TLSAccept" "${ZBX_TLSACCEPT}"
-    update_config_var $ZBX_AGENT_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}"
-    update_config_var $ZBX_AGENT_CONFIG "TLSCRLFile" "${ZBX_TLSCRLFILE}"
+    file_process_from_env $ZBX_AGENT_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}" "${ZBX_TLSCA}"
+    file_process_from_env $ZBX_AGENT_CONFIG "TLSCRLFile" "${ZBX_TLSCRLFILE}" "${ZBX_TLSCRL}"
     update_config_var $ZBX_AGENT_CONFIG "TLSServerCertIssuer" "${ZBX_TLSSERVERCERTISSUER}"
     update_config_var $ZBX_AGENT_CONFIG "TLSServerCertSubject" "${ZBX_TLSSERVERCERTSUBJECT}"
-    update_config_var $ZBX_AGENT_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}"
-    update_config_var $ZBX_AGENT_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}"
+    file_process_from_env $ZBX_AGENT_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}" "${ZBX_TLSCERT}"
+    file_process_from_env $ZBX_AGENT_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}" "${ZBX_TLSKEY}"
     update_config_var $ZBX_AGENT_CONFIG "TLSPSKIdentity" "${ZBX_TLSPSKIDENTITY}"
-    update_config_var $ZBX_AGENT_CONFIG "TLSPSKFile" "${ZBX_TLSPSKFILE}"
+    file_process_from_env $ZBX_AGENT_CONFIG "TLSPSKFile" "${ZBX_TLSPSKFILE}" "${ZBX_TLSPSK}"
 
     update_config_multiple_var $ZBX_AGENT_CONFIG "DenyKey" "${ZBX_DENYKEY}"
     update_config_multiple_var $ZBX_AGENT_CONFIG "AllowKey" "${ZBX_ALLOWKEY}"
diff --git a/Dockerfiles/agent2/ubuntu/Dockerfile b/Dockerfiles/agent2/ubuntu/Dockerfile
index e34de5526..9d35fc196 100644
--- a/Dockerfiles/agent2/ubuntu/Dockerfile
+++ b/Dockerfiles/agent2/ubuntu/Dockerfile
@@ -63,6 +63,7 @@ RUN --mount=type=cache,target=/var/lib/apt/,sharing=locked \
     mkdir -p /etc/zabbix/zabbix_agentd.d && \
     mkdir -p /var/lib/zabbix && \
     mkdir -p /var/lib/zabbix/enc && \
+    mkdir -p /var/lib/zabbix/enc_internal && \
     mkdir -p /var/lib/zabbix/modules && \
     mkdir -p /var/lib/zabbix/buffer && \
     chown --quiet -R zabbix:root /etc/zabbix/ /var/lib/zabbix/ /usr/sbin/zabbix-agent2-plugin/ && \
diff --git a/Dockerfiles/agent2/ubuntu/docker-entrypoint.sh b/Dockerfiles/agent2/ubuntu/docker-entrypoint.sh
index 904af68d6..925e8c59d 100755
--- a/Dockerfiles/agent2/ubuntu/docker-entrypoint.sh
+++ b/Dockerfiles/agent2/ubuntu/docker-entrypoint.sh
@@ -20,6 +20,8 @@ fi
 ZABBIX_USER_HOME_DIR="/var/lib/zabbix"
 # Configuration files directory
 ZABBIX_ETC_DIR="/etc/zabbix"
+# Internal directory for TLS related files, used when TLS*File specified as plain text values
+ZABBIX_INTERNAL_ENC_DIR="${ZABBIX_USER_HOME_DIR}/enc_internal"
 
 escape_spec_char() {
     local var_value=$1
@@ -112,6 +114,19 @@ update_config_multiple_var() {
     done
 }
 
+file_process_from_env() {
+    local config_path=$1
+    local var_name=$2
+    local file_name=$3
+    local var_value=$4
+
+    if [ ! -z "$var_value" ]; then
+        echo -n "$var_value" > "${ZABBIX_INTERNAL_ENC_DIR}/$var_name"
+        file_name="${ZABBIX_INTERNAL_ENC_DIR}/${var_name}"
+    fi
+    update_config_var $config_path "$var_name" "$file_name"
+}
+
 prepare_zbx_agent_config() {
     echo "** Preparing Zabbix agent configuration file"
     ZBX_AGENT_CONFIG=$ZABBIX_ETC_DIR/zabbix_agent2.conf
@@ -185,14 +200,14 @@ prepare_zbx_agent_config() {
     update_config_var $ZBX_AGENT_CONFIG "UnsafeUserParameters" "${ZBX_UNSAFEUSERPARAMETERS}"
     update_config_var $ZBX_AGENT_CONFIG "TLSConnect" "${ZBX_TLSCONNECT}"
     update_config_var $ZBX_AGENT_CONFIG "TLSAccept" "${ZBX_TLSACCEPT}"
-    update_config_var $ZBX_AGENT_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}"
-    update_config_var $ZBX_AGENT_CONFIG "TLSCRLFile" "${ZBX_TLSCRLFILE}"
+    file_process_from_env $ZBX_AGENT_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}" "${ZBX_TLSCA}"
+    file_process_from_env $ZBX_AGENT_CONFIG "TLSCRLFile" "${ZBX_TLSCRLFILE}" "${ZBX_TLSCRL}"
     update_config_var $ZBX_AGENT_CONFIG "TLSServerCertIssuer" "${ZBX_TLSSERVERCERTISSUER}"
     update_config_var $ZBX_AGENT_CONFIG "TLSServerCertSubject" "${ZBX_TLSSERVERCERTSUBJECT}"
-    update_config_var $ZBX_AGENT_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}"
-    update_config_var $ZBX_AGENT_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}"
+    file_process_from_env $ZBX_AGENT_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}" "${ZBX_TLSCERT}"
+    file_process_from_env $ZBX_AGENT_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}" "${ZBX_TLSKEY}"
     update_config_var $ZBX_AGENT_CONFIG "TLSPSKIdentity" "${ZBX_TLSPSKIDENTITY}"
-    update_config_var $ZBX_AGENT_CONFIG "TLSPSKFile" "${ZBX_TLSPSKFILE}"
+    file_process_from_env $ZBX_AGENT_CONFIG "TLSPSKFile" "${ZBX_TLSPSKFILE}" "${ZBX_TLSPSK}"
 
     update_config_multiple_var $ZBX_AGENT_CONFIG "DenyKey" "${ZBX_DENYKEY}"
     update_config_multiple_var $ZBX_AGENT_CONFIG "AllowKey" "${ZBX_ALLOWKEY}"
diff --git a/Dockerfiles/proxy-mysql/README.md b/Dockerfiles/proxy-mysql/README.md
index bcb8314dc..e84629c92 100644
--- a/Dockerfiles/proxy-mysql/README.md
+++ b/Dockerfiles/proxy-mysql/README.md
@@ -220,13 +220,18 @@ ZBX_LOGSLOWQUERIES=3000
 ZBX_TLSCONNECT=unencrypted
 ZBX_TLSACCEPT=unencrypted
 ZBX_TLSCAFILE=
+ZBX_TLSCA=
 ZBX_TLSCRLFILE=
+ZBX_TLSCRL=
 ZBX_TLSSERVERCERTISSUER=
 ZBX_TLSSERVERCERTSUBJECT=
 ZBX_TLSCERTFILE=
+ZBX_TLSCERT=
 ZBX_TLSKEYFILE=
+ZBX_TLSKEY=
 ZBX_TLSPSKIDENTITY=
 ZBX_TLSPSKFILE=
+ZBX_TLSPSK=
 ZBX_TLSCIPHERALL= # Available since 4.4.7
 ZBX_TLSCIPHERALL13= # Available since 4.4.7
 ZBX_TLSCIPHERCERT= # Available since 4.4.7
@@ -253,7 +258,7 @@ The volume allows load additional modules and extend Zabbix proxy using ``LoadMo
 
 ### ``/var/lib/zabbix/enc``
 
-The volume is used to store TLS related files. These file names are specified using ``ZBX_TLSCAFILE``, ``ZBX_TLSCRLFILE``, ``ZBX_TLSKEY_FILE`` and ``ZBX_TLSPSKFILE`` variables.
+The volume is used to store TLS related files. These file names are specified using ``ZBX_TLSCAFILE``, ``ZBX_TLSCRLFILE``, ``ZBX_TLSCERTFILE``, ``ZBX_TLSKEYFILE`` and ``ZBX_TLSPSKFILE`` variables. Additionally it is possible to use environment variables ``ZBX_TLSCA``, ``ZBX_TLSCRL``, ``ZBX_TLSCERT``, ``ZBX_TLSKEY`` and ``ZBX_TLSPSK`` with plaintext values.
 
 ### ``/var/lib/zabbix/ssh_keys``
 
diff --git a/Dockerfiles/proxy-mysql/alpine/Dockerfile b/Dockerfiles/proxy-mysql/alpine/Dockerfile
index 8c5835cbd..d90f93e64 100644
--- a/Dockerfiles/proxy-mysql/alpine/Dockerfile
+++ b/Dockerfiles/proxy-mysql/alpine/Dockerfile
@@ -77,6 +77,7 @@ RUN set -eux && \
     mkdir -p /etc/zabbix && \
     mkdir -p /var/lib/zabbix && \
     mkdir -p /var/lib/zabbix/enc && \
+    mkdir -p /var/lib/zabbix/enc_internal && \
     mkdir -p /usr/lib/zabbix/externalscripts && \
     mkdir -p /var/lib/zabbix/mibs && \
     mkdir -p /var/lib/zabbix/modules && \
diff --git a/Dockerfiles/proxy-mysql/alpine/docker-entrypoint.sh b/Dockerfiles/proxy-mysql/alpine/docker-entrypoint.sh
index 23c8df495..ea4e6d8b9 100755
--- a/Dockerfiles/proxy-mysql/alpine/docker-entrypoint.sh
+++ b/Dockerfiles/proxy-mysql/alpine/docker-entrypoint.sh
@@ -17,6 +17,8 @@ fi
 ZABBIX_USER_HOME_DIR="/var/lib/zabbix"
 # Configuration files directory
 ZABBIX_ETC_DIR="/etc/zabbix"
+# Internal directory for TLS related files, used when TLS*File specified as plain text values
+ZABBIX_INTERNAL_ENC_DIR="${ZABBIX_USER_HOME_DIR}/enc_internal"
 
 : ${DB_CHARACTER_SET:="utf8mb4"}
 : ${DB_CHARACTER_COLLATE:="utf8mb4_bin"}
@@ -140,6 +142,19 @@ update_config_multiple_var() {
     done
 }
 
+file_process_from_env() {
+    local config_path=$1
+    local var_name=$2
+    local file_name=$3
+    local var_value=$4
+
+    if [ ! -z "$var_value" ]; then
+        echo -n "$var_value" > "${ZABBIX_INTERNAL_ENC_DIR}/$var_name"
+        file_name="${ZABBIX_INTERNAL_ENC_DIR}/${var_name}"
+    fi
+    update_config_var $config_path "$var_name" "$file_name"
+}
+
 # Check prerequisites for MySQL database
 check_variables_mysql() {
     if [ ! -n "${DB_SERVER_SOCKET}" ]; then
@@ -470,23 +485,23 @@ update_zbx_config() {
 
     update_config_var $ZBX_CONFIG "TLSConnect" "${ZBX_TLSCONNECT}"
     update_config_var $ZBX_CONFIG "TLSAccept" "${ZBX_TLSACCEPT}"
-    update_config_var $ZBX_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}"
-    update_config_var $ZBX_CONFIG "TLSCRLFile" "${ZBX_TLSCRLFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}" "${ZBX_TLSCA}"
+    file_process_from_env $ZBX_CONFIG "TLSCRLFile" "${ZBX_TLSCRLFILE}" "${ZBX_TLSCRL}"
 
     update_config_var $ZBX_CONFIG "TLSServerCertIssuer" "${ZBX_TLSSERVERCERTISSUER}"
     update_config_var $ZBX_CONFIG "TLSServerCertSubject" "${ZBX_TLSSERVERCERTSUBJECT}"
 
-    update_config_var $ZBX_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}" "${ZBX_TLSCERT}"
     update_config_var $ZBX_CONFIG "TLSCipherAll" "${ZBX_TLSCIPHERALL}"
     update_config_var $ZBX_CONFIG "TLSCipherAll13" "${ZBX_TLSCIPHERALL13}"
     update_config_var $ZBX_CONFIG "TLSCipherCert" "${ZBX_TLSCIPHERCERT}"
     update_config_var $ZBX_CONFIG "TLSCipherCert13" "${ZBX_TLSCIPHERCERT13}"
     update_config_var $ZBX_CONFIG "TLSCipherPSK" "${ZBX_TLSCIPHERPSK}"
     update_config_var $ZBX_CONFIG "TLSCipherPSK13" "${ZBX_TLSCIPHERPSK13}"
-    update_config_var $ZBX_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}" "${ZBX_TLSKEY}"
 
     update_config_var $ZBX_CONFIG "TLSPSKIdentity" "${ZBX_TLSPSKIDENTITY}"
-    update_config_var $ZBX_CONFIG "TLSPSKFile" "${ZBX_TLSPSKFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSPSKFile" "${ZBX_TLSPSKFILE}" "${ZBX_TLSPSK}"
 
     if [ "$(id -u)" != '0' ]; then
         update_config_var $ZBX_CONFIG "User" "$(whoami)"
diff --git a/Dockerfiles/proxy-mysql/centos/Dockerfile b/Dockerfiles/proxy-mysql/centos/Dockerfile
index ded1bf0ed..eca8346d2 100644
--- a/Dockerfiles/proxy-mysql/centos/Dockerfile
+++ b/Dockerfiles/proxy-mysql/centos/Dockerfile
@@ -99,6 +99,7 @@ RUN --mount=type=tmpfs,target=/var/lib/dnf/ \
     mkdir -p /etc/zabbix && \
     mkdir -p /var/lib/zabbix && \
     mkdir -p /var/lib/zabbix/enc && \
+    mkdir -p /var/lib/zabbix/enc_internal && \
     mkdir -p /usr/lib/zabbix/externalscripts && \
     mkdir -p /var/lib/zabbix/mibs && \
     mkdir -p /var/lib/zabbix/modules && \
diff --git a/Dockerfiles/proxy-mysql/centos/docker-entrypoint.sh b/Dockerfiles/proxy-mysql/centos/docker-entrypoint.sh
index 2b346940c..76dc1caaf 100755
--- a/Dockerfiles/proxy-mysql/centos/docker-entrypoint.sh
+++ b/Dockerfiles/proxy-mysql/centos/docker-entrypoint.sh
@@ -17,6 +17,8 @@ fi
 ZABBIX_USER_HOME_DIR="/var/lib/zabbix"
 # Configuration files directory
 ZABBIX_ETC_DIR="/etc/zabbix"
+# Internal directory for TLS related files, used when TLS*File specified as plain text values
+ZABBIX_INTERNAL_ENC_DIR="${ZABBIX_USER_HOME_DIR}/enc_internal"
 
 : ${DB_CHARACTER_SET:="utf8mb4"}
 : ${DB_CHARACTER_COLLATE:="utf8mb4_bin"}
@@ -140,6 +142,19 @@ update_config_multiple_var() {
     done
 }
 
+file_process_from_env() {
+    local config_path=$1
+    local var_name=$2
+    local file_name=$3
+    local var_value=$4
+
+    if [ ! -z "$var_value" ]; then
+        echo -n "$var_value" > "${ZABBIX_INTERNAL_ENC_DIR}/$var_name"
+        file_name="${ZABBIX_INTERNAL_ENC_DIR}/${var_name}"
+    fi
+    update_config_var $config_path "$var_name" "$file_name"
+}
+
 # Check prerequisites for MySQL database
 check_variables_mysql() {
     if [ ! -n "${DB_SERVER_SOCKET}" ]; then
@@ -467,23 +482,23 @@ update_zbx_config() {
 
     update_config_var $ZBX_CONFIG "TLSConnect" "${ZBX_TLSCONNECT}"
     update_config_var $ZBX_CONFIG "TLSAccept" "${ZBX_TLSACCEPT}"
-    update_config_var $ZBX_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}"
-    update_config_var $ZBX_CONFIG "TLSCRLFile" "${ZBX_TLSCRLFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}" "${ZBX_TLSCA}"
+    file_process_from_env $ZBX_CONFIG "TLSCRLFile" "${ZBX_TLSCRLFILE}" "${ZBX_TLSCRL}"
 
     update_config_var $ZBX_CONFIG "TLSServerCertIssuer" "${ZBX_TLSSERVERCERTISSUER}"
     update_config_var $ZBX_CONFIG "TLSServerCertSubject" "${ZBX_TLSSERVERCERTSUBJECT}"
 
-    update_config_var $ZBX_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}" "${ZBX_TLSCERT}"
     update_config_var $ZBX_CONFIG "TLSCipherAll" "${ZBX_TLSCIPHERALL}"
     update_config_var $ZBX_CONFIG "TLSCipherAll13" "${ZBX_TLSCIPHERALL13}"
     update_config_var $ZBX_CONFIG "TLSCipherCert" "${ZBX_TLSCIPHERCERT}"
     update_config_var $ZBX_CONFIG "TLSCipherCert13" "${ZBX_TLSCIPHERCERT13}"
     update_config_var $ZBX_CONFIG "TLSCipherPSK" "${ZBX_TLSCIPHERPSK}"
     update_config_var $ZBX_CONFIG "TLSCipherPSK13" "${ZBX_TLSCIPHERPSK13}"
-    update_config_var $ZBX_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}" "${ZBX_TLSKEY}"
 
     update_config_var $ZBX_CONFIG "TLSPSKIdentity" "${ZBX_TLSPSKIDENTITY}"
-    update_config_var $ZBX_CONFIG "TLSPSKFile" "${ZBX_TLSPSKFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSPSKFile" "${ZBX_TLSPSKFILE}" "${ZBX_TLSPSK}"
 
     if [ "$(id -u)" != '0' ]; then
         update_config_var $ZBX_CONFIG "User" "$(whoami)"
diff --git a/Dockerfiles/proxy-mysql/ol/Dockerfile b/Dockerfiles/proxy-mysql/ol/Dockerfile
index 16068b57e..e75667603 100644
--- a/Dockerfiles/proxy-mysql/ol/Dockerfile
+++ b/Dockerfiles/proxy-mysql/ol/Dockerfile
@@ -81,6 +81,7 @@ RUN --mount=type=tmpfs,target=/var/lib/dnf/ \
     mkdir -p /etc/zabbix && \
     mkdir -p /var/lib/zabbix && \
     mkdir -p /var/lib/zabbix/enc && \
+    mkdir -p /var/lib/zabbix/enc_internal && \
     mkdir -p /usr/lib/zabbix/externalscripts && \
     mkdir -p /var/lib/zabbix/mibs && \
     mkdir -p /var/lib/zabbix/modules && \
diff --git a/Dockerfiles/proxy-mysql/ol/docker-entrypoint.sh b/Dockerfiles/proxy-mysql/ol/docker-entrypoint.sh
index 2b346940c..76dc1caaf 100755
--- a/Dockerfiles/proxy-mysql/ol/docker-entrypoint.sh
+++ b/Dockerfiles/proxy-mysql/ol/docker-entrypoint.sh
@@ -17,6 +17,8 @@ fi
 ZABBIX_USER_HOME_DIR="/var/lib/zabbix"
 # Configuration files directory
 ZABBIX_ETC_DIR="/etc/zabbix"
+# Internal directory for TLS related files, used when TLS*File specified as plain text values
+ZABBIX_INTERNAL_ENC_DIR="${ZABBIX_USER_HOME_DIR}/enc_internal"
 
 : ${DB_CHARACTER_SET:="utf8mb4"}
 : ${DB_CHARACTER_COLLATE:="utf8mb4_bin"}
@@ -140,6 +142,19 @@ update_config_multiple_var() {
     done
 }
 
+file_process_from_env() {
+    local config_path=$1
+    local var_name=$2
+    local file_name=$3
+    local var_value=$4
+
+    if [ ! -z "$var_value" ]; then
+        echo -n "$var_value" > "${ZABBIX_INTERNAL_ENC_DIR}/$var_name"
+        file_name="${ZABBIX_INTERNAL_ENC_DIR}/${var_name}"
+    fi
+    update_config_var $config_path "$var_name" "$file_name"
+}
+
 # Check prerequisites for MySQL database
 check_variables_mysql() {
     if [ ! -n "${DB_SERVER_SOCKET}" ]; then
@@ -467,23 +482,23 @@ update_zbx_config() {
 
     update_config_var $ZBX_CONFIG "TLSConnect" "${ZBX_TLSCONNECT}"
     update_config_var $ZBX_CONFIG "TLSAccept" "${ZBX_TLSACCEPT}"
-    update_config_var $ZBX_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}"
-    update_config_var $ZBX_CONFIG "TLSCRLFile" "${ZBX_TLSCRLFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}" "${ZBX_TLSCA}"
+    file_process_from_env $ZBX_CONFIG "TLSCRLFile" "${ZBX_TLSCRLFILE}" "${ZBX_TLSCRL}"
 
     update_config_var $ZBX_CONFIG "TLSServerCertIssuer" "${ZBX_TLSSERVERCERTISSUER}"
     update_config_var $ZBX_CONFIG "TLSServerCertSubject" "${ZBX_TLSSERVERCERTSUBJECT}"
 
-    update_config_var $ZBX_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}" "${ZBX_TLSCERT}"
     update_config_var $ZBX_CONFIG "TLSCipherAll" "${ZBX_TLSCIPHERALL}"
     update_config_var $ZBX_CONFIG "TLSCipherAll13" "${ZBX_TLSCIPHERALL13}"
     update_config_var $ZBX_CONFIG "TLSCipherCert" "${ZBX_TLSCIPHERCERT}"
     update_config_var $ZBX_CONFIG "TLSCipherCert13" "${ZBX_TLSCIPHERCERT13}"
     update_config_var $ZBX_CONFIG "TLSCipherPSK" "${ZBX_TLSCIPHERPSK}"
     update_config_var $ZBX_CONFIG "TLSCipherPSK13" "${ZBX_TLSCIPHERPSK13}"
-    update_config_var $ZBX_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}" "${ZBX_TLSKEY}"
 
     update_config_var $ZBX_CONFIG "TLSPSKIdentity" "${ZBX_TLSPSKIDENTITY}"
-    update_config_var $ZBX_CONFIG "TLSPSKFile" "${ZBX_TLSPSKFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSPSKFile" "${ZBX_TLSPSKFILE}" "${ZBX_TLSPSK}"
 
     if [ "$(id -u)" != '0' ]; then
         update_config_var $ZBX_CONFIG "User" "$(whoami)"
diff --git a/Dockerfiles/proxy-mysql/rhel/Dockerfile b/Dockerfiles/proxy-mysql/rhel/Dockerfile
index 9f898a1a9..2d451e436 100644
--- a/Dockerfiles/proxy-mysql/rhel/Dockerfile
+++ b/Dockerfiles/proxy-mysql/rhel/Dockerfile
@@ -125,6 +125,7 @@ RUN --mount=type=tmpfs,target=/var/lib/dnf/ \
     mkdir -p /etc/zabbix && \
     mkdir -p /var/lib/zabbix && \
     mkdir -p /var/lib/zabbix/enc && \
+    mkdir -p /var/lib/zabbix/enc_internal && \
     mkdir -p /usr/lib/zabbix/externalscripts && \
     mkdir -p /var/lib/zabbix/mibs && \
     mkdir -p /var/lib/zabbix/modules && \
diff --git a/Dockerfiles/proxy-mysql/rhel/docker-entrypoint.sh b/Dockerfiles/proxy-mysql/rhel/docker-entrypoint.sh
index 2b346940c..76dc1caaf 100755
--- a/Dockerfiles/proxy-mysql/rhel/docker-entrypoint.sh
+++ b/Dockerfiles/proxy-mysql/rhel/docker-entrypoint.sh
@@ -17,6 +17,8 @@ fi
 ZABBIX_USER_HOME_DIR="/var/lib/zabbix"
 # Configuration files directory
 ZABBIX_ETC_DIR="/etc/zabbix"
+# Internal directory for TLS related files, used when TLS*File specified as plain text values
+ZABBIX_INTERNAL_ENC_DIR="${ZABBIX_USER_HOME_DIR}/enc_internal"
 
 : ${DB_CHARACTER_SET:="utf8mb4"}
 : ${DB_CHARACTER_COLLATE:="utf8mb4_bin"}
@@ -140,6 +142,19 @@ update_config_multiple_var() {
     done
 }
 
+file_process_from_env() {
+    local config_path=$1
+    local var_name=$2
+    local file_name=$3
+    local var_value=$4
+
+    if [ ! -z "$var_value" ]; then
+        echo -n "$var_value" > "${ZABBIX_INTERNAL_ENC_DIR}/$var_name"
+        file_name="${ZABBIX_INTERNAL_ENC_DIR}/${var_name}"
+    fi
+    update_config_var $config_path "$var_name" "$file_name"
+}
+
 # Check prerequisites for MySQL database
 check_variables_mysql() {
     if [ ! -n "${DB_SERVER_SOCKET}" ]; then
@@ -467,23 +482,23 @@ update_zbx_config() {
 
     update_config_var $ZBX_CONFIG "TLSConnect" "${ZBX_TLSCONNECT}"
     update_config_var $ZBX_CONFIG "TLSAccept" "${ZBX_TLSACCEPT}"
-    update_config_var $ZBX_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}"
-    update_config_var $ZBX_CONFIG "TLSCRLFile" "${ZBX_TLSCRLFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}" "${ZBX_TLSCA}"
+    file_process_from_env $ZBX_CONFIG "TLSCRLFile" "${ZBX_TLSCRLFILE}" "${ZBX_TLSCRL}"
 
     update_config_var $ZBX_CONFIG "TLSServerCertIssuer" "${ZBX_TLSSERVERCERTISSUER}"
     update_config_var $ZBX_CONFIG "TLSServerCertSubject" "${ZBX_TLSSERVERCERTSUBJECT}"
 
-    update_config_var $ZBX_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}" "${ZBX_TLSCERT}"
     update_config_var $ZBX_CONFIG "TLSCipherAll" "${ZBX_TLSCIPHERALL}"
     update_config_var $ZBX_CONFIG "TLSCipherAll13" "${ZBX_TLSCIPHERALL13}"
     update_config_var $ZBX_CONFIG "TLSCipherCert" "${ZBX_TLSCIPHERCERT}"
     update_config_var $ZBX_CONFIG "TLSCipherCert13" "${ZBX_TLSCIPHERCERT13}"
     update_config_var $ZBX_CONFIG "TLSCipherPSK" "${ZBX_TLSCIPHERPSK}"
     update_config_var $ZBX_CONFIG "TLSCipherPSK13" "${ZBX_TLSCIPHERPSK13}"
-    update_config_var $ZBX_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}" "${ZBX_TLSKEY}"
 
     update_config_var $ZBX_CONFIG "TLSPSKIdentity" "${ZBX_TLSPSKIDENTITY}"
-    update_config_var $ZBX_CONFIG "TLSPSKFile" "${ZBX_TLSPSKFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSPSKFile" "${ZBX_TLSPSKFILE}" "${ZBX_TLSPSK}"
 
     if [ "$(id -u)" != '0' ]; then
         update_config_var $ZBX_CONFIG "User" "$(whoami)"
diff --git a/Dockerfiles/proxy-mysql/ubuntu/Dockerfile b/Dockerfiles/proxy-mysql/ubuntu/Dockerfile
index 820f5c3d2..e72fdf3dc 100644
--- a/Dockerfiles/proxy-mysql/ubuntu/Dockerfile
+++ b/Dockerfiles/proxy-mysql/ubuntu/Dockerfile
@@ -79,6 +79,7 @@ RUN --mount=type=cache,target=/var/lib/apt/,sharing=locked \
     mkdir -p /etc/zabbix && \
     mkdir -p /var/lib/zabbix && \
     mkdir -p /var/lib/zabbix/enc && \
+    mkdir -p /var/lib/zabbix/enc_internal && \
     mkdir -p /usr/lib/zabbix/externalscripts && \
     mkdir -p /var/lib/zabbix/mibs && \
     mkdir -p /var/lib/zabbix/modules && \
diff --git a/Dockerfiles/proxy-mysql/ubuntu/docker-entrypoint.sh b/Dockerfiles/proxy-mysql/ubuntu/docker-entrypoint.sh
index 88a376d1d..9f157bd26 100755
--- a/Dockerfiles/proxy-mysql/ubuntu/docker-entrypoint.sh
+++ b/Dockerfiles/proxy-mysql/ubuntu/docker-entrypoint.sh
@@ -17,6 +17,8 @@ fi
 ZABBIX_USER_HOME_DIR="/var/lib/zabbix"
 # Configuration files directory
 ZABBIX_ETC_DIR="/etc/zabbix"
+# Internal directory for TLS related files, used when TLS*File specified as plain text values
+ZABBIX_INTERNAL_ENC_DIR="${ZABBIX_USER_HOME_DIR}/enc_internal"
 
 : ${DB_CHARACTER_SET:="utf8mb4"}
 : ${DB_CHARACTER_COLLATE:="utf8mb4_bin"}
@@ -140,6 +142,19 @@ update_config_multiple_var() {
     done
 }
 
+file_process_from_env() {
+    local config_path=$1
+    local var_name=$2
+    local file_name=$3
+    local var_value=$4
+
+    if [ ! -z "$var_value" ]; then
+        echo -n "$var_value" > "${ZABBIX_INTERNAL_ENC_DIR}/$var_name"
+        file_name="${ZABBIX_INTERNAL_ENC_DIR}/${var_name}"
+    fi
+    update_config_var $config_path "$var_name" "$file_name"
+}
+
 # Check prerequisites for MySQL database
 check_variables_mysql() {
     if [ ! -n "${DB_SERVER_SOCKET}" ]; then
@@ -467,23 +482,23 @@ update_zbx_config() {
 
     update_config_var $ZBX_CONFIG "TLSConnect" "${ZBX_TLSCONNECT}"
     update_config_var $ZBX_CONFIG "TLSAccept" "${ZBX_TLSACCEPT}"
-    update_config_var $ZBX_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}"
-    update_config_var $ZBX_CONFIG "TLSCRLFile" "${ZBX_TLSCRLFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}" "${ZBX_TLSCA}"
+    file_process_from_env $ZBX_CONFIG "TLSCRLFile" "${ZBX_TLSCRLFILE}" "${ZBX_TLSCRL}"
 
     update_config_var $ZBX_CONFIG "TLSServerCertIssuer" "${ZBX_TLSSERVERCERTISSUER}"
     update_config_var $ZBX_CONFIG "TLSServerCertSubject" "${ZBX_TLSSERVERCERTSUBJECT}"
 
-    update_config_var $ZBX_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}" "${ZBX_TLSCERT}"
     update_config_var $ZBX_CONFIG "TLSCipherAll" "${ZBX_TLSCIPHERALL}"
     update_config_var $ZBX_CONFIG "TLSCipherAll13" "${ZBX_TLSCIPHERALL13}"
     update_config_var $ZBX_CONFIG "TLSCipherCert" "${ZBX_TLSCIPHERCERT}"
     update_config_var $ZBX_CONFIG "TLSCipherCert13" "${ZBX_TLSCIPHERCERT13}"
     update_config_var $ZBX_CONFIG "TLSCipherPSK" "${ZBX_TLSCIPHERPSK}"
     update_config_var $ZBX_CONFIG "TLSCipherPSK13" "${ZBX_TLSCIPHERPSK13}"
-    update_config_var $ZBX_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}" "${ZBX_TLSKEY}"
 
     update_config_var $ZBX_CONFIG "TLSPSKIdentity" "${ZBX_TLSPSKIDENTITY}"
-    update_config_var $ZBX_CONFIG "TLSPSKFile" "${ZBX_TLSPSKFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSPSKFile" "${ZBX_TLSPSKFILE}" "${ZBX_TLSPSK}"
 
     if [ "$(id -u)" != '0' ]; then
         update_config_var $ZBX_CONFIG "User" "$(whoami)"
diff --git a/Dockerfiles/proxy-sqlite3/README.md b/Dockerfiles/proxy-sqlite3/README.md
index b7e71f408..71549c051 100644
--- a/Dockerfiles/proxy-sqlite3/README.md
+++ b/Dockerfiles/proxy-sqlite3/README.md
@@ -174,13 +174,18 @@ ZBX_LOGSLOWQUERIES=3000
 ZBX_TLSCONNECT=unencrypted
 ZBX_TLSACCEPT=unencrypted
 ZBX_TLSCAFILE=
+ZBX_TLSCA=
 ZBX_TLSCRLFILE=
+ZBX_TLSCRL=
 ZBX_TLSSERVERCERTISSUER=
 ZBX_TLSSERVERCERTSUBJECT=
 ZBX_TLSCERTFILE=
+ZBX_TLSCERT=
 ZBX_TLSKEYFILE=
+ZBX_TLSKEY=
 ZBX_TLSPSKIDENTITY=
 ZBX_TLSPSKFILE=
+ZBX_TLSPSK=
 ZBX_TLSCIPHERALL= # Available since 4.4.7
 ZBX_TLSCIPHERALL13= # Available since 4.4.7
 ZBX_TLSCIPHERCERT= # Available since 4.4.7
@@ -211,7 +216,7 @@ The volume allows load additional modules and extend Zabbix proxy using ``LoadMo
 
 ### ``/var/lib/zabbix/enc``
 
-The volume is used to store TLS related files. These file names are specified using ``ZBX_TLSCAFILE``, ``ZBX_TLSCRLFILE``, ``ZBX_TLSKEY_FILE`` and ``ZBX_TLSPSKFILE`` variables.
+The volume is used to store TLS related files. These file names are specified using ``ZBX_TLSCAFILE``, ``ZBX_TLSCRLFILE``, ``ZBX_TLSCERTFILE``, ``ZBX_TLSKEYFILE`` and ``ZBX_TLSPSKFILE`` variables. Additionally it is possible to use environment variables ``ZBX_TLSCA``, ``ZBX_TLSCRL``, ``ZBX_TLSCERT``, ``ZBX_TLSKEY`` and ``ZBX_TLSPSK`` with plaintext values.
 
 ### ``/var/lib/zabbix/ssh_keys``
 
diff --git a/Dockerfiles/proxy-sqlite3/alpine/Dockerfile b/Dockerfiles/proxy-sqlite3/alpine/Dockerfile
index ff0692f7e..356bf5969 100644
--- a/Dockerfiles/proxy-sqlite3/alpine/Dockerfile
+++ b/Dockerfiles/proxy-sqlite3/alpine/Dockerfile
@@ -75,6 +75,7 @@ RUN set -eux && \
     mkdir -p /var/lib/zabbix && \
     mkdir -p /var/lib/zabbix/db_data && \
     mkdir -p /var/lib/zabbix/enc && \
+    mkdir -p /var/lib/zabbix/enc_internal && \
     mkdir -p /usr/lib/zabbix/externalscripts && \
     mkdir -p /var/lib/zabbix/mibs && \
     mkdir -p /var/lib/zabbix/modules && \
diff --git a/Dockerfiles/proxy-sqlite3/alpine/docker-entrypoint.sh b/Dockerfiles/proxy-sqlite3/alpine/docker-entrypoint.sh
index 5be5a7230..6a13762a5 100755
--- a/Dockerfiles/proxy-sqlite3/alpine/docker-entrypoint.sh
+++ b/Dockerfiles/proxy-sqlite3/alpine/docker-entrypoint.sh
@@ -17,6 +17,8 @@ fi
 ZABBIX_USER_HOME_DIR="/var/lib/zabbix"
 # Configuration files directory
 ZABBIX_ETC_DIR="/etc/zabbix"
+# Internal directory for TLS related files, used when TLS*File specified as plain text values
+ZABBIX_INTERNAL_ENC_DIR="${ZABBIX_USER_HOME_DIR}/enc_internal"
 
 escape_spec_char() {
     local var_value=$1
@@ -106,6 +108,19 @@ update_config_multiple_var() {
     done
 }
 
+file_process_from_env() {
+    local config_path=$1
+    local var_name=$2
+    local file_name=$3
+    local var_value=$4
+
+    if [ ! -z "$var_value" ]; then
+        echo -n "$var_value" > "${ZABBIX_INTERNAL_ENC_DIR}/$var_name"
+        file_name="${ZABBIX_INTERNAL_ENC_DIR}/${var_name}"
+    fi
+    update_config_var $config_path "$var_name" "$file_name"
+}
+
 update_zbx_config() {
     echo "** Preparing Zabbix proxy configuration file"
 
@@ -224,22 +239,22 @@ update_zbx_config() {
 
     update_config_var $ZBX_CONFIG "TLSConnect" "${ZBX_TLSCONNECT}"
     update_config_var $ZBX_CONFIG "TLSAccept" "${ZBX_TLSACCEPT}"
-    update_config_var $ZBX_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}"
-    update_config_var $ZBX_CONFIG "TLSCRLFile" "${ZBX_TLSCRLFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}" "${ZBX_TLSCA}"
+    file_process_from_env $ZBX_CONFIG "TLSCRLFile" "${ZBX_TLSCRLFILE}" "${ZBX_TLSCRL}"
     update_config_var $ZBX_CONFIG "TLSServerCertIssuer" "${ZBX_TLSSERVERCERTISSUER}"
     update_config_var $ZBX_CONFIG "TLSServerCertSubject" "${ZBX_TLSSERVERCERTSUBJECT}"
 
-    update_config_var $ZBX_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}" "${ZBX_TLSCERT}"
     update_config_var $ZBX_CONFIG "TLSCipherAll" "${ZBX_TLSCIPHERALL}"
     update_config_var $ZBX_CONFIG "TLSCipherAll13" "${ZBX_TLSCIPHERALL13}"
     update_config_var $ZBX_CONFIG "TLSCipherCert" "${ZBX_TLSCIPHERCERT}"
     update_config_var $ZBX_CONFIG "TLSCipherCert13" "${ZBX_TLSCIPHERCERT13}"
     update_config_var $ZBX_CONFIG "TLSCipherPSK" "${ZBX_TLSCIPHERPSK}"
     update_config_var $ZBX_CONFIG "TLSCipherPSK13" "${ZBX_TLSCIPHERPSK13}"
-    update_config_var $ZBX_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}" "${ZBX_TLSKEY}"
 
     update_config_var $ZBX_CONFIG "TLSPSKIdentity" "${ZBX_TLSPSKIDENTITY}"
-    update_config_var $ZBX_CONFIG "TLSPSKFile" "${ZBX_TLSPSKFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSPSKFile" "${ZBX_TLSPSKFILE}" "${ZBX_TLSPSK}"
 
     if [ "$(id -u)" != '0' ]; then
         update_config_var $ZBX_CONFIG "User" "$(whoami)"
diff --git a/Dockerfiles/proxy-sqlite3/centos/Dockerfile b/Dockerfiles/proxy-sqlite3/centos/Dockerfile
index 8af4296b1..a09eb80e6 100644
--- a/Dockerfiles/proxy-sqlite3/centos/Dockerfile
+++ b/Dockerfiles/proxy-sqlite3/centos/Dockerfile
@@ -90,6 +90,7 @@ RUN --mount=type=tmpfs,target=/var/lib/dnf/ \
     mkdir -p /var/lib/zabbix && \
     mkdir -p /var/lib/zabbix/db_data && \
     mkdir -p /var/lib/zabbix/enc && \
+    mkdir -p /var/lib/zabbix/enc_internal && \
     mkdir -p /usr/lib/zabbix/externalscripts && \
     mkdir -p /var/lib/zabbix/mibs && \
     mkdir -p /var/lib/zabbix/modules && \
diff --git a/Dockerfiles/proxy-sqlite3/centos/docker-entrypoint.sh b/Dockerfiles/proxy-sqlite3/centos/docker-entrypoint.sh
index 5be5a7230..6a13762a5 100755
--- a/Dockerfiles/proxy-sqlite3/centos/docker-entrypoint.sh
+++ b/Dockerfiles/proxy-sqlite3/centos/docker-entrypoint.sh
@@ -17,6 +17,8 @@ fi
 ZABBIX_USER_HOME_DIR="/var/lib/zabbix"
 # Configuration files directory
 ZABBIX_ETC_DIR="/etc/zabbix"
+# Internal directory for TLS related files, used when TLS*File specified as plain text values
+ZABBIX_INTERNAL_ENC_DIR="${ZABBIX_USER_HOME_DIR}/enc_internal"
 
 escape_spec_char() {
     local var_value=$1
@@ -106,6 +108,19 @@ update_config_multiple_var() {
     done
 }
 
+file_process_from_env() {
+    local config_path=$1
+    local var_name=$2
+    local file_name=$3
+    local var_value=$4
+
+    if [ ! -z "$var_value" ]; then
+        echo -n "$var_value" > "${ZABBIX_INTERNAL_ENC_DIR}/$var_name"
+        file_name="${ZABBIX_INTERNAL_ENC_DIR}/${var_name}"
+    fi
+    update_config_var $config_path "$var_name" "$file_name"
+}
+
 update_zbx_config() {
     echo "** Preparing Zabbix proxy configuration file"
 
@@ -224,22 +239,22 @@ update_zbx_config() {
 
     update_config_var $ZBX_CONFIG "TLSConnect" "${ZBX_TLSCONNECT}"
     update_config_var $ZBX_CONFIG "TLSAccept" "${ZBX_TLSACCEPT}"
-    update_config_var $ZBX_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}"
-    update_config_var $ZBX_CONFIG "TLSCRLFile" "${ZBX_TLSCRLFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}" "${ZBX_TLSCA}"
+    file_process_from_env $ZBX_CONFIG "TLSCRLFile" "${ZBX_TLSCRLFILE}" "${ZBX_TLSCRL}"
     update_config_var $ZBX_CONFIG "TLSServerCertIssuer" "${ZBX_TLSSERVERCERTISSUER}"
     update_config_var $ZBX_CONFIG "TLSServerCertSubject" "${ZBX_TLSSERVERCERTSUBJECT}"
 
-    update_config_var $ZBX_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}" "${ZBX_TLSCERT}"
     update_config_var $ZBX_CONFIG "TLSCipherAll" "${ZBX_TLSCIPHERALL}"
     update_config_var $ZBX_CONFIG "TLSCipherAll13" "${ZBX_TLSCIPHERALL13}"
     update_config_var $ZBX_CONFIG "TLSCipherCert" "${ZBX_TLSCIPHERCERT}"
     update_config_var $ZBX_CONFIG "TLSCipherCert13" "${ZBX_TLSCIPHERCERT13}"
     update_config_var $ZBX_CONFIG "TLSCipherPSK" "${ZBX_TLSCIPHERPSK}"
     update_config_var $ZBX_CONFIG "TLSCipherPSK13" "${ZBX_TLSCIPHERPSK13}"
-    update_config_var $ZBX_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}" "${ZBX_TLSKEY}"
 
     update_config_var $ZBX_CONFIG "TLSPSKIdentity" "${ZBX_TLSPSKIDENTITY}"
-    update_config_var $ZBX_CONFIG "TLSPSKFile" "${ZBX_TLSPSKFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSPSKFile" "${ZBX_TLSPSKFILE}" "${ZBX_TLSPSK}"
 
     if [ "$(id -u)" != '0' ]; then
         update_config_var $ZBX_CONFIG "User" "$(whoami)"
diff --git a/Dockerfiles/proxy-sqlite3/ol/Dockerfile b/Dockerfiles/proxy-sqlite3/ol/Dockerfile
index 7d85338d4..c23ab0040 100644
--- a/Dockerfiles/proxy-sqlite3/ol/Dockerfile
+++ b/Dockerfiles/proxy-sqlite3/ol/Dockerfile
@@ -78,6 +78,7 @@ RUN --mount=type=tmpfs,target=/var/lib/dnf/ \
     mkdir -p /var/lib/zabbix && \
     mkdir -p /var/lib/zabbix/db_data && \
     mkdir -p /var/lib/zabbix/enc && \
+    mkdir -p /var/lib/zabbix/enc_internal && \
     mkdir -p /usr/lib/zabbix/externalscripts && \
     mkdir -p /var/lib/zabbix/mibs && \
     mkdir -p /var/lib/zabbix/modules && \
diff --git a/Dockerfiles/proxy-sqlite3/ol/docker-entrypoint.sh b/Dockerfiles/proxy-sqlite3/ol/docker-entrypoint.sh
index 5be5a7230..6a13762a5 100755
--- a/Dockerfiles/proxy-sqlite3/ol/docker-entrypoint.sh
+++ b/Dockerfiles/proxy-sqlite3/ol/docker-entrypoint.sh
@@ -17,6 +17,8 @@ fi
 ZABBIX_USER_HOME_DIR="/var/lib/zabbix"
 # Configuration files directory
 ZABBIX_ETC_DIR="/etc/zabbix"
+# Internal directory for TLS related files, used when TLS*File specified as plain text values
+ZABBIX_INTERNAL_ENC_DIR="${ZABBIX_USER_HOME_DIR}/enc_internal"
 
 escape_spec_char() {
     local var_value=$1
@@ -106,6 +108,19 @@ update_config_multiple_var() {
     done
 }
 
+file_process_from_env() {
+    local config_path=$1
+    local var_name=$2
+    local file_name=$3
+    local var_value=$4
+
+    if [ ! -z "$var_value" ]; then
+        echo -n "$var_value" > "${ZABBIX_INTERNAL_ENC_DIR}/$var_name"
+        file_name="${ZABBIX_INTERNAL_ENC_DIR}/${var_name}"
+    fi
+    update_config_var $config_path "$var_name" "$file_name"
+}
+
 update_zbx_config() {
     echo "** Preparing Zabbix proxy configuration file"
 
@@ -224,22 +239,22 @@ update_zbx_config() {
 
     update_config_var $ZBX_CONFIG "TLSConnect" "${ZBX_TLSCONNECT}"
     update_config_var $ZBX_CONFIG "TLSAccept" "${ZBX_TLSACCEPT}"
-    update_config_var $ZBX_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}"
-    update_config_var $ZBX_CONFIG "TLSCRLFile" "${ZBX_TLSCRLFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}" "${ZBX_TLSCA}"
+    file_process_from_env $ZBX_CONFIG "TLSCRLFile" "${ZBX_TLSCRLFILE}" "${ZBX_TLSCRL}"
     update_config_var $ZBX_CONFIG "TLSServerCertIssuer" "${ZBX_TLSSERVERCERTISSUER}"
     update_config_var $ZBX_CONFIG "TLSServerCertSubject" "${ZBX_TLSSERVERCERTSUBJECT}"
 
-    update_config_var $ZBX_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}" "${ZBX_TLSCERT}"
     update_config_var $ZBX_CONFIG "TLSCipherAll" "${ZBX_TLSCIPHERALL}"
     update_config_var $ZBX_CONFIG "TLSCipherAll13" "${ZBX_TLSCIPHERALL13}"
     update_config_var $ZBX_CONFIG "TLSCipherCert" "${ZBX_TLSCIPHERCERT}"
     update_config_var $ZBX_CONFIG "TLSCipherCert13" "${ZBX_TLSCIPHERCERT13}"
     update_config_var $ZBX_CONFIG "TLSCipherPSK" "${ZBX_TLSCIPHERPSK}"
     update_config_var $ZBX_CONFIG "TLSCipherPSK13" "${ZBX_TLSCIPHERPSK13}"
-    update_config_var $ZBX_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}" "${ZBX_TLSKEY}"
 
     update_config_var $ZBX_CONFIG "TLSPSKIdentity" "${ZBX_TLSPSKIDENTITY}"
-    update_config_var $ZBX_CONFIG "TLSPSKFile" "${ZBX_TLSPSKFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSPSKFile" "${ZBX_TLSPSKFILE}" "${ZBX_TLSPSK}"
 
     if [ "$(id -u)" != '0' ]; then
         update_config_var $ZBX_CONFIG "User" "$(whoami)"
diff --git a/Dockerfiles/proxy-sqlite3/rhel/Dockerfile b/Dockerfiles/proxy-sqlite3/rhel/Dockerfile
index 583a79637..14b5539ea 100644
--- a/Dockerfiles/proxy-sqlite3/rhel/Dockerfile
+++ b/Dockerfiles/proxy-sqlite3/rhel/Dockerfile
@@ -112,6 +112,7 @@ RUN --mount=type=tmpfs,target=/var/lib/dnf/ \
     mkdir -p /var/lib/zabbix && \
     mkdir -p /var/lib/zabbix/db_data && \
     mkdir -p /var/lib/zabbix/enc && \
+    mkdir -p /var/lib/zabbix/enc_internal && \
     mkdir -p /usr/lib/zabbix/externalscripts && \
     mkdir -p /var/lib/zabbix/mibs && \
     mkdir -p /var/lib/zabbix/modules && \
diff --git a/Dockerfiles/proxy-sqlite3/rhel/docker-entrypoint.sh b/Dockerfiles/proxy-sqlite3/rhel/docker-entrypoint.sh
index 5be5a7230..6a13762a5 100755
--- a/Dockerfiles/proxy-sqlite3/rhel/docker-entrypoint.sh
+++ b/Dockerfiles/proxy-sqlite3/rhel/docker-entrypoint.sh
@@ -17,6 +17,8 @@ fi
 ZABBIX_USER_HOME_DIR="/var/lib/zabbix"
 # Configuration files directory
 ZABBIX_ETC_DIR="/etc/zabbix"
+# Internal directory for TLS related files, used when TLS*File specified as plain text values
+ZABBIX_INTERNAL_ENC_DIR="${ZABBIX_USER_HOME_DIR}/enc_internal"
 
 escape_spec_char() {
     local var_value=$1
@@ -106,6 +108,19 @@ update_config_multiple_var() {
     done
 }
 
+file_process_from_env() {
+    local config_path=$1
+    local var_name=$2
+    local file_name=$3
+    local var_value=$4
+
+    if [ ! -z "$var_value" ]; then
+        echo -n "$var_value" > "${ZABBIX_INTERNAL_ENC_DIR}/$var_name"
+        file_name="${ZABBIX_INTERNAL_ENC_DIR}/${var_name}"
+    fi
+    update_config_var $config_path "$var_name" "$file_name"
+}
+
 update_zbx_config() {
     echo "** Preparing Zabbix proxy configuration file"
 
@@ -224,22 +239,22 @@ update_zbx_config() {
 
     update_config_var $ZBX_CONFIG "TLSConnect" "${ZBX_TLSCONNECT}"
     update_config_var $ZBX_CONFIG "TLSAccept" "${ZBX_TLSACCEPT}"
-    update_config_var $ZBX_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}"
-    update_config_var $ZBX_CONFIG "TLSCRLFile" "${ZBX_TLSCRLFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}" "${ZBX_TLSCA}"
+    file_process_from_env $ZBX_CONFIG "TLSCRLFile" "${ZBX_TLSCRLFILE}" "${ZBX_TLSCRL}"
     update_config_var $ZBX_CONFIG "TLSServerCertIssuer" "${ZBX_TLSSERVERCERTISSUER}"
     update_config_var $ZBX_CONFIG "TLSServerCertSubject" "${ZBX_TLSSERVERCERTSUBJECT}"
 
-    update_config_var $ZBX_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}" "${ZBX_TLSCERT}"
     update_config_var $ZBX_CONFIG "TLSCipherAll" "${ZBX_TLSCIPHERALL}"
     update_config_var $ZBX_CONFIG "TLSCipherAll13" "${ZBX_TLSCIPHERALL13}"
     update_config_var $ZBX_CONFIG "TLSCipherCert" "${ZBX_TLSCIPHERCERT}"
     update_config_var $ZBX_CONFIG "TLSCipherCert13" "${ZBX_TLSCIPHERCERT13}"
     update_config_var $ZBX_CONFIG "TLSCipherPSK" "${ZBX_TLSCIPHERPSK}"
     update_config_var $ZBX_CONFIG "TLSCipherPSK13" "${ZBX_TLSCIPHERPSK13}"
-    update_config_var $ZBX_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}" "${ZBX_TLSKEY}"
 
     update_config_var $ZBX_CONFIG "TLSPSKIdentity" "${ZBX_TLSPSKIDENTITY}"
-    update_config_var $ZBX_CONFIG "TLSPSKFile" "${ZBX_TLSPSKFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSPSKFile" "${ZBX_TLSPSKFILE}" "${ZBX_TLSPSK}"
 
     if [ "$(id -u)" != '0' ]; then
         update_config_var $ZBX_CONFIG "User" "$(whoami)"
diff --git a/Dockerfiles/proxy-sqlite3/ubuntu/Dockerfile b/Dockerfiles/proxy-sqlite3/ubuntu/Dockerfile
index 9a9d2c6a5..8ce848ed9 100644
--- a/Dockerfiles/proxy-sqlite3/ubuntu/Dockerfile
+++ b/Dockerfiles/proxy-sqlite3/ubuntu/Dockerfile
@@ -76,6 +76,7 @@ RUN --mount=type=cache,target=/var/lib/apt/,sharing=locked \
     mkdir -p /var/lib/zabbix && \
     mkdir -p /var/lib/zabbix/db_data && \
     mkdir -p /var/lib/zabbix/enc && \
+    mkdir -p /var/lib/zabbix/enc_internal && \
     mkdir -p /usr/lib/zabbix/externalscripts && \
     mkdir -p /var/lib/zabbix/mibs && \
     mkdir -p /var/lib/zabbix/modules && \
diff --git a/Dockerfiles/proxy-sqlite3/ubuntu/docker-entrypoint.sh b/Dockerfiles/proxy-sqlite3/ubuntu/docker-entrypoint.sh
index 02c883320..b1a1a6b7b 100755
--- a/Dockerfiles/proxy-sqlite3/ubuntu/docker-entrypoint.sh
+++ b/Dockerfiles/proxy-sqlite3/ubuntu/docker-entrypoint.sh
@@ -17,6 +17,8 @@ fi
 ZABBIX_USER_HOME_DIR="/var/lib/zabbix"
 # Configuration files directory
 ZABBIX_ETC_DIR="/etc/zabbix"
+# Internal directory for TLS related files, used when TLS*File specified as plain text values
+ZABBIX_INTERNAL_ENC_DIR="${ZABBIX_USER_HOME_DIR}/enc_internal"
 
 escape_spec_char() {
     local var_value=$1
@@ -106,6 +108,19 @@ update_config_multiple_var() {
     done
 }
 
+file_process_from_env() {
+    local config_path=$1
+    local var_name=$2
+    local file_name=$3
+    local var_value=$4
+
+    if [ ! -z "$var_value" ]; then
+        echo -n "$var_value" > "${ZABBIX_INTERNAL_ENC_DIR}/$var_name"
+        file_name="${ZABBIX_INTERNAL_ENC_DIR}/${var_name}"
+    fi
+    update_config_var $config_path "$var_name" "$file_name"
+}
+
 update_zbx_config() {
     echo "** Preparing Zabbix proxy configuration file"
 
@@ -224,22 +239,22 @@ update_zbx_config() {
 
     update_config_var $ZBX_CONFIG "TLSConnect" "${ZBX_TLSCONNECT}"
     update_config_var $ZBX_CONFIG "TLSAccept" "${ZBX_TLSACCEPT}"
-    update_config_var $ZBX_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}"
-    update_config_var $ZBX_CONFIG "TLSCRLFile" "${ZBX_TLSCRLFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}" "${ZBX_TLSCA}"
+    file_process_from_env $ZBX_CONFIG "TLSCRLFile" "${ZBX_TLSCRLFILE}" "${ZBX_TLSCRL}"
     update_config_var $ZBX_CONFIG "TLSServerCertIssuer" "${ZBX_TLSSERVERCERTISSUER}"
     update_config_var $ZBX_CONFIG "TLSServerCertSubject" "${ZBX_TLSSERVERCERTSUBJECT}"
 
-    update_config_var $ZBX_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}" "${ZBX_TLSCERT}"
     update_config_var $ZBX_CONFIG "TLSCipherAll" "${ZBX_TLSCIPHERALL}"
     update_config_var $ZBX_CONFIG "TLSCipherAll13" "${ZBX_TLSCIPHERALL13}"
     update_config_var $ZBX_CONFIG "TLSCipherCert" "${ZBX_TLSCIPHERCERT}"
     update_config_var $ZBX_CONFIG "TLSCipherCert13" "${ZBX_TLSCIPHERCERT13}"
     update_config_var $ZBX_CONFIG "TLSCipherPSK" "${ZBX_TLSCIPHERPSK}"
     update_config_var $ZBX_CONFIG "TLSCipherPSK13" "${ZBX_TLSCIPHERPSK13}"
-    update_config_var $ZBX_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}" "${ZBX_TLSKEY}"
 
     update_config_var $ZBX_CONFIG "TLSPSKIdentity" "${ZBX_TLSPSKIDENTITY}"
-    update_config_var $ZBX_CONFIG "TLSPSKFile" "${ZBX_TLSPSKFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSPSKFile" "${ZBX_TLSPSKFILE}" "${ZBX_TLSPSK}"
 
     if [ "$(id -u)" != '0' ]; then
         update_config_var $ZBX_CONFIG "User" "$(whoami)"
diff --git a/Dockerfiles/server-mysql/README.md b/Dockerfiles/server-mysql/README.md
index 1c6cdbc50..4318a257d 100644
--- a/Dockerfiles/server-mysql/README.md
+++ b/Dockerfiles/server-mysql/README.md
@@ -206,9 +206,13 @@ ZBX_STARTPROXYPOLLERS=1
 ZBX_PROXYCONFIGFREQUENCY=3600
 ZBX_PROXYDATAFREQUENCY=1
 ZBX_TLSCAFILE=
+ZBX_TLSCA=
 ZBX_TLSCRLFILE=
+ZBX_TLSCRL=
 ZBX_TLSCERTFILE=
+ZBX_TLSCERT=
 ZBX_TLSKEYFILE=
+ZBX_TLSKEY=
 ZBX_TLSCIPHERALL= # Available since 4.4.7
 ZBX_TLSCIPHERALL13= # Available since 4.4.7
 ZBX_TLSCIPHERCERT= # Available since 4.4.7
@@ -240,7 +244,7 @@ The volume allows load additional modules and extend Zabbix server using ``LoadM
 
 ### ``/var/lib/zabbix/enc``
 
-The volume is used to store TLS related files. These file names are specified using ``ZBX_TLSCAFILE``, ``ZBX_TLSCRLFILE``, ``ZBX_TLSKEY_FILE`` and ``ZBX_TLSPSKFILE`` variables.
+The volume is used to store TLS related files. These file names are specified using ``ZBX_TLSCAFILE``, ``ZBX_TLSCRLFILE``, ``ZBX_TLSCERTFILE`` and ``ZBX_TLSKEYFILE`` variables. Additionally it is possible to use environment variables ``ZBX_TLSCA``, ``ZBX_TLSCRL``, ``ZBX_TLSCERT`` and ``ZBX_TLSKEY`` with plaintext values.
 
 ### ``/var/lib/zabbix/ssh_keys``
 
diff --git a/Dockerfiles/server-mysql/alpine/Dockerfile b/Dockerfiles/server-mysql/alpine/Dockerfile
index e1c8362fe..b8b784dd9 100644
--- a/Dockerfiles/server-mysql/alpine/Dockerfile
+++ b/Dockerfiles/server-mysql/alpine/Dockerfile
@@ -80,6 +80,7 @@ RUN set -eux && \
     mkdir -p /usr/lib/zabbix/alertscripts && \
     mkdir -p /var/lib/zabbix/dbscripts && \
     mkdir -p /var/lib/zabbix/enc && \
+    mkdir -p /var/lib/zabbix/enc_internal && \
     mkdir -p /var/lib/zabbix/export && \
     mkdir -p /usr/lib/zabbix/externalscripts && \
     mkdir -p /var/lib/zabbix/mibs && \
diff --git a/Dockerfiles/server-mysql/alpine/docker-entrypoint.sh b/Dockerfiles/server-mysql/alpine/docker-entrypoint.sh
index dfcc35489..3ab40147d 100755
--- a/Dockerfiles/server-mysql/alpine/docker-entrypoint.sh
+++ b/Dockerfiles/server-mysql/alpine/docker-entrypoint.sh
@@ -14,6 +14,8 @@ fi
 ZABBIX_USER_HOME_DIR="/var/lib/zabbix"
 # Configuration files directory
 ZABBIX_ETC_DIR="/etc/zabbix"
+# Internal directory for TLS related files, used when TLS*File specified as plain text values
+ZABBIX_INTERNAL_ENC_DIR="${ZABBIX_USER_HOME_DIR}/enc_internal"
 
 : ${DB_CHARACTER_SET:="utf8mb4"}
 : ${DB_CHARACTER_COLLATE:="utf8mb4_bin"}
@@ -137,6 +139,19 @@ update_config_multiple_var() {
     done
 }
 
+file_process_from_env() {
+    local config_path=$1
+    local var_name=$2
+    local file_name=$3
+    local var_value=$4
+
+    if [ ! -z "$var_value" ]; then
+        echo -n "$var_value" > "${ZABBIX_INTERNAL_ENC_DIR}/$var_name"
+        file_name="${ZABBIX_INTERNAL_ENC_DIR}/${var_name}"
+    fi
+    update_config_var $config_path "$var_name" "$file_name"
+}
+
 # Check prerequisites for MySQL database
 check_variables_mysql() {
     if [ ! -n "${DB_SERVER_SOCKET}" ]; then
@@ -499,20 +514,17 @@ update_zbx_config() {
     update_config_var $ZBX_CONFIG "LoadModulePath" "$ZABBIX_USER_HOME_DIR/modules/"
     update_config_multiple_var $ZBX_CONFIG "LoadModule" "${ZBX_LOADMODULE}"
 
-    update_config_var $ZBX_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}"
-    update_config_var $ZBX_CONFIG "TLSCRLFile" "${ZBX_TLSCRLFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}" "${ZBX_TLSCA}"
+    file_process_from_env $ZBX_CONFIG "TLSCRLFile" "${ZBX_TLSCRLFILE}" "${ZBX_TLSCRL}"
 
-    update_config_var $ZBX_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}" "${ZBX_TLSCERT}"
     update_config_var $ZBX_CONFIG "TLSCipherAll" "${ZBX_TLSCIPHERALL}"
     update_config_var $ZBX_CONFIG "TLSCipherAll13" "${ZBX_TLSCIPHERALL13}"
     update_config_var $ZBX_CONFIG "TLSCipherCert" "${ZBX_TLSCIPHERCERT}"
     update_config_var $ZBX_CONFIG "TLSCipherCert13" "${ZBX_TLSCIPHERCERT13}"
     update_config_var $ZBX_CONFIG "TLSCipherPSK" "${ZBX_TLSCIPHERPSK}"
     update_config_var $ZBX_CONFIG "TLSCipherPSK13" "${ZBX_TLSCIPHERPSK13}"
-    update_config_var $ZBX_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}"
-
-    update_config_var $ZBX_CONFIG "TLSPSKIdentity" "${ZBX_TLSPSKIDENTITY}"
-    update_config_var $ZBX_CONFIG "TLSPSKFile" "${ZBX_TLSPSKFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}" "${ZBX_TLSKEY}"
 
     update_config_var $ZBX_CONFIG "ServiceManagerSyncFrequency" "${ZBX_SERVICEMANAGERSYNCFREQUENCY}"
 
diff --git a/Dockerfiles/server-mysql/centos/Dockerfile b/Dockerfiles/server-mysql/centos/Dockerfile
index e41ff2466..5be7eeea6 100644
--- a/Dockerfiles/server-mysql/centos/Dockerfile
+++ b/Dockerfiles/server-mysql/centos/Dockerfile
@@ -104,6 +104,7 @@ RUN --mount=type=tmpfs,target=/var/lib/dnf/ \
     mkdir -p /usr/lib/zabbix/alertscripts && \
     mkdir -p /var/lib/zabbix/dbscripts && \
     mkdir -p /var/lib/zabbix/enc && \
+    mkdir -p /var/lib/zabbix/enc_internal && \
     mkdir -p /var/lib/zabbix/export && \
     mkdir -p /usr/lib/zabbix/externalscripts && \
     mkdir -p /var/lib/zabbix/mibs && \
diff --git a/Dockerfiles/server-mysql/centos/docker-entrypoint.sh b/Dockerfiles/server-mysql/centos/docker-entrypoint.sh
index 0f3e4a4f2..c0319dceb 100755
--- a/Dockerfiles/server-mysql/centos/docker-entrypoint.sh
+++ b/Dockerfiles/server-mysql/centos/docker-entrypoint.sh
@@ -14,6 +14,8 @@ fi
 ZABBIX_USER_HOME_DIR="/var/lib/zabbix"
 # Configuration files directory
 ZABBIX_ETC_DIR="/etc/zabbix"
+# Internal directory for TLS related files, used when TLS*File specified as plain text values
+ZABBIX_INTERNAL_ENC_DIR="${ZABBIX_USER_HOME_DIR}/enc_internal"
 
 : ${DB_CHARACTER_SET:="utf8mb4"}
 : ${DB_CHARACTER_COLLATE:="utf8mb4_bin"}
@@ -137,6 +139,19 @@ update_config_multiple_var() {
     done
 }
 
+file_process_from_env() {
+    local config_path=$1
+    local var_name=$2
+    local file_name=$3
+    local var_value=$4
+
+    if [ ! -z "$var_value" ]; then
+        echo -n "$var_value" > "${ZABBIX_INTERNAL_ENC_DIR}/$var_name"
+        file_name="${ZABBIX_INTERNAL_ENC_DIR}/${var_name}"
+    fi
+    update_config_var $config_path "$var_name" "$file_name"
+}
+
 # Check prerequisites for MySQL database
 check_variables_mysql() {
     if [ ! -n "${DB_SERVER_SOCKET}" ]; then
@@ -496,20 +511,17 @@ update_zbx_config() {
     update_config_var $ZBX_CONFIG "LoadModulePath" "$ZABBIX_USER_HOME_DIR/modules/"
     update_config_multiple_var $ZBX_CONFIG "LoadModule" "${ZBX_LOADMODULE}"
 
-    update_config_var $ZBX_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}"
-    update_config_var $ZBX_CONFIG "TLSCRLFile" "${ZBX_TLSCRLFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}" "${ZBX_TLSCA}"
+    file_process_from_env $ZBX_CONFIG "TLSCRLFile" "${ZBX_TLSCRLFILE}" "${ZBX_TLSCRL}"
 
-    update_config_var $ZBX_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}" "${ZBX_TLSCERT}"
     update_config_var $ZBX_CONFIG "TLSCipherAll" "${ZBX_TLSCIPHERALL}"
     update_config_var $ZBX_CONFIG "TLSCipherAll13" "${ZBX_TLSCIPHERALL13}"
     update_config_var $ZBX_CONFIG "TLSCipherCert" "${ZBX_TLSCIPHERCERT}"
     update_config_var $ZBX_CONFIG "TLSCipherCert13" "${ZBX_TLSCIPHERCERT13}"
     update_config_var $ZBX_CONFIG "TLSCipherPSK" "${ZBX_TLSCIPHERPSK}"
     update_config_var $ZBX_CONFIG "TLSCipherPSK13" "${ZBX_TLSCIPHERPSK13}"
-    update_config_var $ZBX_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}"
-
-    update_config_var $ZBX_CONFIG "TLSPSKIdentity" "${ZBX_TLSPSKIDENTITY}"
-    update_config_var $ZBX_CONFIG "TLSPSKFile" "${ZBX_TLSPSKFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}" "${ZBX_TLSKEY}"
 
     update_config_var $ZBX_CONFIG "ServiceManagerSyncFrequency" "${ZBX_SERVICEMANAGERSYNCFREQUENCY}"
 
diff --git a/Dockerfiles/server-mysql/ol/Dockerfile b/Dockerfiles/server-mysql/ol/Dockerfile
index e24922f89..b004d2f5f 100644
--- a/Dockerfiles/server-mysql/ol/Dockerfile
+++ b/Dockerfiles/server-mysql/ol/Dockerfile
@@ -95,6 +95,7 @@ RUN --mount=type=tmpfs,target=/var/lib/dnf/ \
     mkdir -p /usr/lib/zabbix/alertscripts && \
     mkdir -p /var/lib/zabbix/dbscripts && \
     mkdir -p /var/lib/zabbix/enc && \
+    mkdir -p /var/lib/zabbix/enc_internal && \
     mkdir -p /var/lib/zabbix/export && \
     mkdir -p /usr/lib/zabbix/externalscripts && \
     mkdir -p /var/lib/zabbix/mibs && \
diff --git a/Dockerfiles/server-mysql/ol/docker-entrypoint.sh b/Dockerfiles/server-mysql/ol/docker-entrypoint.sh
index 0f3e4a4f2..c0319dceb 100755
--- a/Dockerfiles/server-mysql/ol/docker-entrypoint.sh
+++ b/Dockerfiles/server-mysql/ol/docker-entrypoint.sh
@@ -14,6 +14,8 @@ fi
 ZABBIX_USER_HOME_DIR="/var/lib/zabbix"
 # Configuration files directory
 ZABBIX_ETC_DIR="/etc/zabbix"
+# Internal directory for TLS related files, used when TLS*File specified as plain text values
+ZABBIX_INTERNAL_ENC_DIR="${ZABBIX_USER_HOME_DIR}/enc_internal"
 
 : ${DB_CHARACTER_SET:="utf8mb4"}
 : ${DB_CHARACTER_COLLATE:="utf8mb4_bin"}
@@ -137,6 +139,19 @@ update_config_multiple_var() {
     done
 }
 
+file_process_from_env() {
+    local config_path=$1
+    local var_name=$2
+    local file_name=$3
+    local var_value=$4
+
+    if [ ! -z "$var_value" ]; then
+        echo -n "$var_value" > "${ZABBIX_INTERNAL_ENC_DIR}/$var_name"
+        file_name="${ZABBIX_INTERNAL_ENC_DIR}/${var_name}"
+    fi
+    update_config_var $config_path "$var_name" "$file_name"
+}
+
 # Check prerequisites for MySQL database
 check_variables_mysql() {
     if [ ! -n "${DB_SERVER_SOCKET}" ]; then
@@ -496,20 +511,17 @@ update_zbx_config() {
     update_config_var $ZBX_CONFIG "LoadModulePath" "$ZABBIX_USER_HOME_DIR/modules/"
     update_config_multiple_var $ZBX_CONFIG "LoadModule" "${ZBX_LOADMODULE}"
 
-    update_config_var $ZBX_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}"
-    update_config_var $ZBX_CONFIG "TLSCRLFile" "${ZBX_TLSCRLFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}" "${ZBX_TLSCA}"
+    file_process_from_env $ZBX_CONFIG "TLSCRLFile" "${ZBX_TLSCRLFILE}" "${ZBX_TLSCRL}"
 
-    update_config_var $ZBX_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}" "${ZBX_TLSCERT}"
     update_config_var $ZBX_CONFIG "TLSCipherAll" "${ZBX_TLSCIPHERALL}"
     update_config_var $ZBX_CONFIG "TLSCipherAll13" "${ZBX_TLSCIPHERALL13}"
     update_config_var $ZBX_CONFIG "TLSCipherCert" "${ZBX_TLSCIPHERCERT}"
     update_config_var $ZBX_CONFIG "TLSCipherCert13" "${ZBX_TLSCIPHERCERT13}"
     update_config_var $ZBX_CONFIG "TLSCipherPSK" "${ZBX_TLSCIPHERPSK}"
     update_config_var $ZBX_CONFIG "TLSCipherPSK13" "${ZBX_TLSCIPHERPSK13}"
-    update_config_var $ZBX_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}"
-
-    update_config_var $ZBX_CONFIG "TLSPSKIdentity" "${ZBX_TLSPSKIDENTITY}"
-    update_config_var $ZBX_CONFIG "TLSPSKFile" "${ZBX_TLSPSKFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}" "${ZBX_TLSKEY}"
 
     update_config_var $ZBX_CONFIG "ServiceManagerSyncFrequency" "${ZBX_SERVICEMANAGERSYNCFREQUENCY}"
 
diff --git a/Dockerfiles/server-mysql/rhel/Dockerfile b/Dockerfiles/server-mysql/rhel/Dockerfile
index 43804568b..f3b7c7ca5 100644
--- a/Dockerfiles/server-mysql/rhel/Dockerfile
+++ b/Dockerfiles/server-mysql/rhel/Dockerfile
@@ -129,6 +129,7 @@ RUN --mount=type=tmpfs,target=/var/lib/dnf/ \
     mkdir -p /usr/lib/zabbix/alertscripts && \
     mkdir -p /var/lib/zabbix/dbscripts && \
     mkdir -p /var/lib/zabbix/enc && \
+    mkdir -p /var/lib/zabbix/enc_internal && \
     mkdir -p /var/lib/zabbix/export && \
     mkdir -p /usr/lib/zabbix/externalscripts && \
     mkdir -p /var/lib/zabbix/mibs && \
diff --git a/Dockerfiles/server-mysql/rhel/docker-entrypoint.sh b/Dockerfiles/server-mysql/rhel/docker-entrypoint.sh
index 0f3e4a4f2..c0319dceb 100755
--- a/Dockerfiles/server-mysql/rhel/docker-entrypoint.sh
+++ b/Dockerfiles/server-mysql/rhel/docker-entrypoint.sh
@@ -14,6 +14,8 @@ fi
 ZABBIX_USER_HOME_DIR="/var/lib/zabbix"
 # Configuration files directory
 ZABBIX_ETC_DIR="/etc/zabbix"
+# Internal directory for TLS related files, used when TLS*File specified as plain text values
+ZABBIX_INTERNAL_ENC_DIR="${ZABBIX_USER_HOME_DIR}/enc_internal"
 
 : ${DB_CHARACTER_SET:="utf8mb4"}
 : ${DB_CHARACTER_COLLATE:="utf8mb4_bin"}
@@ -137,6 +139,19 @@ update_config_multiple_var() {
     done
 }
 
+file_process_from_env() {
+    local config_path=$1
+    local var_name=$2
+    local file_name=$3
+    local var_value=$4
+
+    if [ ! -z "$var_value" ]; then
+        echo -n "$var_value" > "${ZABBIX_INTERNAL_ENC_DIR}/$var_name"
+        file_name="${ZABBIX_INTERNAL_ENC_DIR}/${var_name}"
+    fi
+    update_config_var $config_path "$var_name" "$file_name"
+}
+
 # Check prerequisites for MySQL database
 check_variables_mysql() {
     if [ ! -n "${DB_SERVER_SOCKET}" ]; then
@@ -496,20 +511,17 @@ update_zbx_config() {
     update_config_var $ZBX_CONFIG "LoadModulePath" "$ZABBIX_USER_HOME_DIR/modules/"
     update_config_multiple_var $ZBX_CONFIG "LoadModule" "${ZBX_LOADMODULE}"
 
-    update_config_var $ZBX_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}"
-    update_config_var $ZBX_CONFIG "TLSCRLFile" "${ZBX_TLSCRLFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}" "${ZBX_TLSCA}"
+    file_process_from_env $ZBX_CONFIG "TLSCRLFile" "${ZBX_TLSCRLFILE}" "${ZBX_TLSCRL}"
 
-    update_config_var $ZBX_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}" "${ZBX_TLSCERT}"
     update_config_var $ZBX_CONFIG "TLSCipherAll" "${ZBX_TLSCIPHERALL}"
     update_config_var $ZBX_CONFIG "TLSCipherAll13" "${ZBX_TLSCIPHERALL13}"
     update_config_var $ZBX_CONFIG "TLSCipherCert" "${ZBX_TLSCIPHERCERT}"
     update_config_var $ZBX_CONFIG "TLSCipherCert13" "${ZBX_TLSCIPHERCERT13}"
     update_config_var $ZBX_CONFIG "TLSCipherPSK" "${ZBX_TLSCIPHERPSK}"
     update_config_var $ZBX_CONFIG "TLSCipherPSK13" "${ZBX_TLSCIPHERPSK13}"
-    update_config_var $ZBX_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}"
-
-    update_config_var $ZBX_CONFIG "TLSPSKIdentity" "${ZBX_TLSPSKIDENTITY}"
-    update_config_var $ZBX_CONFIG "TLSPSKFile" "${ZBX_TLSPSKFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}" "${ZBX_TLSKEY}"
 
     update_config_var $ZBX_CONFIG "ServiceManagerSyncFrequency" "${ZBX_SERVICEMANAGERSYNCFREQUENCY}"
 
diff --git a/Dockerfiles/server-mysql/ubuntu/Dockerfile b/Dockerfiles/server-mysql/ubuntu/Dockerfile
index 345ec7011..281816e64 100644
--- a/Dockerfiles/server-mysql/ubuntu/Dockerfile
+++ b/Dockerfiles/server-mysql/ubuntu/Dockerfile
@@ -83,6 +83,7 @@ RUN --mount=type=cache,target=/var/lib/apt/,sharing=locked \
     mkdir -p /usr/lib/zabbix/alertscripts && \
     mkdir -p /var/lib/zabbix/dbscripts && \
     mkdir -p /var/lib/zabbix/enc && \
+    mkdir -p /var/lib/zabbix/enc_internal && \
     mkdir -p /var/lib/zabbix/export && \
     mkdir -p /usr/lib/zabbix/externalscripts && \
     mkdir -p /var/lib/zabbix/mibs && \
diff --git a/Dockerfiles/server-mysql/ubuntu/docker-entrypoint.sh b/Dockerfiles/server-mysql/ubuntu/docker-entrypoint.sh
index 3cf095f57..103036469 100755
--- a/Dockerfiles/server-mysql/ubuntu/docker-entrypoint.sh
+++ b/Dockerfiles/server-mysql/ubuntu/docker-entrypoint.sh
@@ -14,6 +14,8 @@ fi
 ZABBIX_USER_HOME_DIR="/var/lib/zabbix"
 # Configuration files directory
 ZABBIX_ETC_DIR="/etc/zabbix"
+# Internal directory for TLS related files, used when TLS*File specified as plain text values
+ZABBIX_INTERNAL_ENC_DIR="${ZABBIX_USER_HOME_DIR}/enc_internal"
 
 : ${DB_CHARACTER_SET:="utf8mb4"}
 : ${DB_CHARACTER_COLLATE:="utf8mb4_bin"}
@@ -137,6 +139,19 @@ update_config_multiple_var() {
     done
 }
 
+file_process_from_env() {
+    local config_path=$1
+    local var_name=$2
+    local file_name=$3
+    local var_value=$4
+
+    if [ ! -z "$var_value" ]; then
+        echo -n "$var_value" > "${ZABBIX_INTERNAL_ENC_DIR}/$var_name"
+        file_name="${ZABBIX_INTERNAL_ENC_DIR}/${var_name}"
+    fi
+    update_config_var $config_path "$var_name" "$file_name"
+}
+
 # Check prerequisites for MySQL database
 check_variables_mysql() {
     if [ ! -n "${DB_SERVER_SOCKET}" ]; then
@@ -496,20 +511,17 @@ update_zbx_config() {
     update_config_var $ZBX_CONFIG "LoadModulePath" "$ZABBIX_USER_HOME_DIR/modules/"
     update_config_multiple_var $ZBX_CONFIG "LoadModule" "${ZBX_LOADMODULE}"
 
-    update_config_var $ZBX_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}"
-    update_config_var $ZBX_CONFIG "TLSCRLFile" "${ZBX_TLSCRLFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}" "${ZBX_TLSCA}"
+    file_process_from_env $ZBX_CONFIG "TLSCRLFile" "${ZBX_TLSCRLFILE}" "${ZBX_TLSCRL}"
 
-    update_config_var $ZBX_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}" "${ZBX_TLSCERT}"
     update_config_var $ZBX_CONFIG "TLSCipherAll" "${ZBX_TLSCIPHERALL}"
     update_config_var $ZBX_CONFIG "TLSCipherAll13" "${ZBX_TLSCIPHERALL13}"
     update_config_var $ZBX_CONFIG "TLSCipherCert" "${ZBX_TLSCIPHERCERT}"
     update_config_var $ZBX_CONFIG "TLSCipherCert13" "${ZBX_TLSCIPHERCERT13}"
     update_config_var $ZBX_CONFIG "TLSCipherPSK" "${ZBX_TLSCIPHERPSK}"
     update_config_var $ZBX_CONFIG "TLSCipherPSK13" "${ZBX_TLSCIPHERPSK13}"
-    update_config_var $ZBX_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}"
-
-    update_config_var $ZBX_CONFIG "TLSPSKIdentity" "${ZBX_TLSPSKIDENTITY}"
-    update_config_var $ZBX_CONFIG "TLSPSKFile" "${ZBX_TLSPSKFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}" "${ZBX_TLSKEY}"
 
     update_config_var $ZBX_CONFIG "ServiceManagerSyncFrequency" "${ZBX_SERVICEMANAGERSYNCFREQUENCY}"
 
diff --git a/Dockerfiles/server-pgsql/README.md b/Dockerfiles/server-pgsql/README.md
index e5fdf05ea..7d9b14d32 100644
--- a/Dockerfiles/server-pgsql/README.md
+++ b/Dockerfiles/server-pgsql/README.md
@@ -207,9 +207,13 @@ ZBX_STARTPROXYPOLLERS=1
 ZBX_PROXYCONFIGFREQUENCY=3600
 ZBX_PROXYDATAFREQUENCY=1
 ZBX_TLSCAFILE=
+ZBX_TLSCA=
 ZBX_TLSCRLFILE=
+ZBX_TLSCRL=
 ZBX_TLSCERTFILE=
+ZBX_TLSCERT=
 ZBX_TLSKEYFILE=
+ZBX_TLSKEY=
 ZBX_TLSCIPHERALL= # Available since 4.4.7
 ZBX_TLSCIPHERALL13= # Available since 4.4.7
 ZBX_TLSCIPHERCERT= # Available since 4.4.7
@@ -240,7 +244,7 @@ The volume allows load additional modules and extend Zabbix server using ``LoadM
 
 ### ``/var/lib/zabbix/enc``
 
-The volume is used to store TLS related files. These file names are specified using ``ZBX_TLSCAFILE``, ``ZBX_TLSCRLFILE``, ``ZBX_TLSKEY_FILE`` and ``ZBX_TLSPSKFILE`` variables.
+The volume is used to store TLS related files. These file names are specified using ``ZBX_TLSCAFILE``, ``ZBX_TLSCRLFILE``, ``ZBX_TLSCERTFILE`` and ``ZBX_TLSKEYFILE`` variables. Additionally it is possible to use environment variables ``ZBX_TLSCA``, ``ZBX_TLSCRL``, ``ZBX_TLSCERT`` and ``ZBX_TLSKEY`` with plaintext values.
 
 ### ``/var/lib/zabbix/ssh_keys``
 
diff --git a/Dockerfiles/server-pgsql/alpine/Dockerfile b/Dockerfiles/server-pgsql/alpine/Dockerfile
index 160d76e91..dff8704a3 100644
--- a/Dockerfiles/server-pgsql/alpine/Dockerfile
+++ b/Dockerfiles/server-pgsql/alpine/Dockerfile
@@ -79,6 +79,7 @@ RUN set -eux && \
     mkdir -p /usr/lib/zabbix/alertscripts && \
     mkdir -p /var/lib/zabbix/dbscripts && \
     mkdir -p /var/lib/zabbix/enc && \
+    mkdir -p /var/lib/zabbix/enc_internal && \
     mkdir -p /var/lib/zabbix/export && \
     mkdir -p /usr/lib/zabbix/externalscripts && \
     mkdir -p /var/lib/zabbix/mibs && \
diff --git a/Dockerfiles/server-pgsql/alpine/docker-entrypoint.sh b/Dockerfiles/server-pgsql/alpine/docker-entrypoint.sh
index debc97889..6efb47b0d 100755
--- a/Dockerfiles/server-pgsql/alpine/docker-entrypoint.sh
+++ b/Dockerfiles/server-pgsql/alpine/docker-entrypoint.sh
@@ -17,6 +17,8 @@ fi
 ZABBIX_USER_HOME_DIR="/var/lib/zabbix"
 # Configuration files directory
 ZABBIX_ETC_DIR="/etc/zabbix"
+# Internal directory for TLS related files, used when TLS*File specified as plain text values
+ZABBIX_INTERNAL_ENC_DIR="${ZABBIX_USER_HOME_DIR}/enc_internal"
 
 # usage: file_env VAR [DEFAULT]
 # as example: file_env 'MYSQL_PASSWORD' 'zabbix'
@@ -137,6 +139,19 @@ update_config_multiple_var() {
     done
 }
 
+file_process_from_env() {
+    local config_path=$1
+    local var_name=$2
+    local file_name=$3
+    local var_value=$4
+
+    if [ ! -z "$var_value" ]; then
+        echo -n "$var_value" > "${ZABBIX_INTERNAL_ENC_DIR}/$var_name"
+        file_name="${ZABBIX_INTERNAL_ENC_DIR}/${var_name}"
+    fi
+    update_config_var $config_path "$var_name" "$file_name"
+}
+
 # Check prerequisites for PostgreSQL database
 check_variables_postgresql() {
     file_env POSTGRES_USER
@@ -516,20 +531,17 @@ update_zbx_config() {
     update_config_var $ZBX_CONFIG "LoadModulePath" "$ZABBIX_USER_HOME_DIR/modules/"
     update_config_multiple_var $ZBX_CONFIG "LoadModule" "${ZBX_LOADMODULE}"
 
-    update_config_var $ZBX_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}"
-    update_config_var $ZBX_CONFIG "TLSCRLFile" "${ZBX_TLSCRLFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}" "${ZBX_TLSCA}"
+    file_process_from_env $ZBX_CONFIG "TLSCRLFile" "${ZBX_TLSCRLFILE}" "${ZBX_TLSCRL}"
 
-    update_config_var $ZBX_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}" "${ZBX_TLSCERT}"
     update_config_var $ZBX_CONFIG "TLSCipherAll" "${ZBX_TLSCIPHERALL}"
     update_config_var $ZBX_CONFIG "TLSCipherAll13" "${ZBX_TLSCIPHERALL13}"
     update_config_var $ZBX_CONFIG "TLSCipherCert" "${ZBX_TLSCIPHERCERT}"
     update_config_var $ZBX_CONFIG "TLSCipherCert13" "${ZBX_TLSCIPHERCERT13}"
     update_config_var $ZBX_CONFIG "TLSCipherPSK" "${ZBX_TLSCIPHERPSK}"
     update_config_var $ZBX_CONFIG "TLSCipherPSK13" "${ZBX_TLSCIPHERPSK13}"
-    update_config_var $ZBX_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}"
-
-    update_config_var $ZBX_CONFIG "TLSPSKIdentity" "${ZBX_TLSPSKIDENTITY}"
-    update_config_var $ZBX_CONFIG "TLSPSKFile" "${ZBX_TLSPSKFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}" "${ZBX_TLSKEY}"
 
     update_config_var $ZBX_CONFIG "ServiceManagerSyncFrequency" "${ZBX_SERVICEMANAGERSYNCFREQUENCY}"
 
diff --git a/Dockerfiles/server-pgsql/centos/Dockerfile b/Dockerfiles/server-pgsql/centos/Dockerfile
index 0b55b444f..7eedcb89a 100644
--- a/Dockerfiles/server-pgsql/centos/Dockerfile
+++ b/Dockerfiles/server-pgsql/centos/Dockerfile
@@ -104,6 +104,7 @@ RUN --mount=type=tmpfs,target=/var/lib/dnf/ \
     mkdir -p /usr/lib/zabbix/alertscripts && \
     mkdir -p /var/lib/zabbix/dbscripts && \
     mkdir -p /var/lib/zabbix/enc && \
+    mkdir -p /var/lib/zabbix/enc_internal && \
     mkdir -p /var/lib/zabbix/export && \
     mkdir -p /usr/lib/zabbix/externalscripts && \
     mkdir -p /var/lib/zabbix/mibs && \
diff --git a/Dockerfiles/server-pgsql/centos/docker-entrypoint.sh b/Dockerfiles/server-pgsql/centos/docker-entrypoint.sh
index debc97889..6efb47b0d 100755
--- a/Dockerfiles/server-pgsql/centos/docker-entrypoint.sh
+++ b/Dockerfiles/server-pgsql/centos/docker-entrypoint.sh
@@ -17,6 +17,8 @@ fi
 ZABBIX_USER_HOME_DIR="/var/lib/zabbix"
 # Configuration files directory
 ZABBIX_ETC_DIR="/etc/zabbix"
+# Internal directory for TLS related files, used when TLS*File specified as plain text values
+ZABBIX_INTERNAL_ENC_DIR="${ZABBIX_USER_HOME_DIR}/enc_internal"
 
 # usage: file_env VAR [DEFAULT]
 # as example: file_env 'MYSQL_PASSWORD' 'zabbix'
@@ -137,6 +139,19 @@ update_config_multiple_var() {
     done
 }
 
+file_process_from_env() {
+    local config_path=$1
+    local var_name=$2
+    local file_name=$3
+    local var_value=$4
+
+    if [ ! -z "$var_value" ]; then
+        echo -n "$var_value" > "${ZABBIX_INTERNAL_ENC_DIR}/$var_name"
+        file_name="${ZABBIX_INTERNAL_ENC_DIR}/${var_name}"
+    fi
+    update_config_var $config_path "$var_name" "$file_name"
+}
+
 # Check prerequisites for PostgreSQL database
 check_variables_postgresql() {
     file_env POSTGRES_USER
@@ -516,20 +531,17 @@ update_zbx_config() {
     update_config_var $ZBX_CONFIG "LoadModulePath" "$ZABBIX_USER_HOME_DIR/modules/"
     update_config_multiple_var $ZBX_CONFIG "LoadModule" "${ZBX_LOADMODULE}"
 
-    update_config_var $ZBX_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}"
-    update_config_var $ZBX_CONFIG "TLSCRLFile" "${ZBX_TLSCRLFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}" "${ZBX_TLSCA}"
+    file_process_from_env $ZBX_CONFIG "TLSCRLFile" "${ZBX_TLSCRLFILE}" "${ZBX_TLSCRL}"
 
-    update_config_var $ZBX_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}" "${ZBX_TLSCERT}"
     update_config_var $ZBX_CONFIG "TLSCipherAll" "${ZBX_TLSCIPHERALL}"
     update_config_var $ZBX_CONFIG "TLSCipherAll13" "${ZBX_TLSCIPHERALL13}"
     update_config_var $ZBX_CONFIG "TLSCipherCert" "${ZBX_TLSCIPHERCERT}"
     update_config_var $ZBX_CONFIG "TLSCipherCert13" "${ZBX_TLSCIPHERCERT13}"
     update_config_var $ZBX_CONFIG "TLSCipherPSK" "${ZBX_TLSCIPHERPSK}"
     update_config_var $ZBX_CONFIG "TLSCipherPSK13" "${ZBX_TLSCIPHERPSK13}"
-    update_config_var $ZBX_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}"
-
-    update_config_var $ZBX_CONFIG "TLSPSKIdentity" "${ZBX_TLSPSKIDENTITY}"
-    update_config_var $ZBX_CONFIG "TLSPSKFile" "${ZBX_TLSPSKFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}" "${ZBX_TLSKEY}"
 
     update_config_var $ZBX_CONFIG "ServiceManagerSyncFrequency" "${ZBX_SERVICEMANAGERSYNCFREQUENCY}"
 
diff --git a/Dockerfiles/server-pgsql/ol/Dockerfile b/Dockerfiles/server-pgsql/ol/Dockerfile
index f58ad118e..567645f6a 100644
--- a/Dockerfiles/server-pgsql/ol/Dockerfile
+++ b/Dockerfiles/server-pgsql/ol/Dockerfile
@@ -94,6 +94,7 @@ RUN --mount=type=tmpfs,target=/var/lib/dnf/ \
     mkdir -p /usr/lib/zabbix/alertscripts && \
     mkdir -p /var/lib/zabbix/dbscripts && \
     mkdir -p /var/lib/zabbix/enc && \
+    mkdir -p /var/lib/zabbix/enc_internal && \
     mkdir -p /var/lib/zabbix/export && \
     mkdir -p /usr/lib/zabbix/externalscripts && \
     mkdir -p /var/lib/zabbix/mibs && \
diff --git a/Dockerfiles/server-pgsql/ol/docker-entrypoint.sh b/Dockerfiles/server-pgsql/ol/docker-entrypoint.sh
index debc97889..6efb47b0d 100755
--- a/Dockerfiles/server-pgsql/ol/docker-entrypoint.sh
+++ b/Dockerfiles/server-pgsql/ol/docker-entrypoint.sh
@@ -17,6 +17,8 @@ fi
 ZABBIX_USER_HOME_DIR="/var/lib/zabbix"
 # Configuration files directory
 ZABBIX_ETC_DIR="/etc/zabbix"
+# Internal directory for TLS related files, used when TLS*File specified as plain text values
+ZABBIX_INTERNAL_ENC_DIR="${ZABBIX_USER_HOME_DIR}/enc_internal"
 
 # usage: file_env VAR [DEFAULT]
 # as example: file_env 'MYSQL_PASSWORD' 'zabbix'
@@ -137,6 +139,19 @@ update_config_multiple_var() {
     done
 }
 
+file_process_from_env() {
+    local config_path=$1
+    local var_name=$2
+    local file_name=$3
+    local var_value=$4
+
+    if [ ! -z "$var_value" ]; then
+        echo -n "$var_value" > "${ZABBIX_INTERNAL_ENC_DIR}/$var_name"
+        file_name="${ZABBIX_INTERNAL_ENC_DIR}/${var_name}"
+    fi
+    update_config_var $config_path "$var_name" "$file_name"
+}
+
 # Check prerequisites for PostgreSQL database
 check_variables_postgresql() {
     file_env POSTGRES_USER
@@ -516,20 +531,17 @@ update_zbx_config() {
     update_config_var $ZBX_CONFIG "LoadModulePath" "$ZABBIX_USER_HOME_DIR/modules/"
     update_config_multiple_var $ZBX_CONFIG "LoadModule" "${ZBX_LOADMODULE}"
 
-    update_config_var $ZBX_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}"
-    update_config_var $ZBX_CONFIG "TLSCRLFile" "${ZBX_TLSCRLFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}" "${ZBX_TLSCA}"
+    file_process_from_env $ZBX_CONFIG "TLSCRLFile" "${ZBX_TLSCRLFILE}" "${ZBX_TLSCRL}"
 
-    update_config_var $ZBX_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}" "${ZBX_TLSCERT}"
     update_config_var $ZBX_CONFIG "TLSCipherAll" "${ZBX_TLSCIPHERALL}"
     update_config_var $ZBX_CONFIG "TLSCipherAll13" "${ZBX_TLSCIPHERALL13}"
     update_config_var $ZBX_CONFIG "TLSCipherCert" "${ZBX_TLSCIPHERCERT}"
     update_config_var $ZBX_CONFIG "TLSCipherCert13" "${ZBX_TLSCIPHERCERT13}"
     update_config_var $ZBX_CONFIG "TLSCipherPSK" "${ZBX_TLSCIPHERPSK}"
     update_config_var $ZBX_CONFIG "TLSCipherPSK13" "${ZBX_TLSCIPHERPSK13}"
-    update_config_var $ZBX_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}"
-
-    update_config_var $ZBX_CONFIG "TLSPSKIdentity" "${ZBX_TLSPSKIDENTITY}"
-    update_config_var $ZBX_CONFIG "TLSPSKFile" "${ZBX_TLSPSKFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}" "${ZBX_TLSKEY}"
 
     update_config_var $ZBX_CONFIG "ServiceManagerSyncFrequency" "${ZBX_SERVICEMANAGERSYNCFREQUENCY}"
 
diff --git a/Dockerfiles/server-pgsql/ubuntu/Dockerfile b/Dockerfiles/server-pgsql/ubuntu/Dockerfile
index cedaf16fc..eca2da53e 100644
--- a/Dockerfiles/server-pgsql/ubuntu/Dockerfile
+++ b/Dockerfiles/server-pgsql/ubuntu/Dockerfile
@@ -83,6 +83,7 @@ RUN --mount=type=cache,target=/var/lib/apt/,sharing=locked \
     mkdir -p /usr/lib/zabbix/alertscripts && \
     mkdir -p /var/lib/zabbix/dbscripts && \
     mkdir -p /var/lib/zabbix/enc && \
+    mkdir -p /var/lib/zabbix/enc_internal && \
     mkdir -p /var/lib/zabbix/export && \
     mkdir -p /usr/lib/zabbix/externalscripts && \
     mkdir -p /var/lib/zabbix/mibs && \
diff --git a/Dockerfiles/server-pgsql/ubuntu/docker-entrypoint.sh b/Dockerfiles/server-pgsql/ubuntu/docker-entrypoint.sh
index ce177863d..01a20afc6 100755
--- a/Dockerfiles/server-pgsql/ubuntu/docker-entrypoint.sh
+++ b/Dockerfiles/server-pgsql/ubuntu/docker-entrypoint.sh
@@ -17,6 +17,8 @@ fi
 ZABBIX_USER_HOME_DIR="/var/lib/zabbix"
 # Configuration files directory
 ZABBIX_ETC_DIR="/etc/zabbix"
+# Internal directory for TLS related files, used when TLS*File specified as plain text values
+ZABBIX_INTERNAL_ENC_DIR="${ZABBIX_USER_HOME_DIR}/enc_internal"
 
 # usage: file_env VAR [DEFAULT]
 # as example: file_env 'MYSQL_PASSWORD' 'zabbix'
@@ -137,6 +139,19 @@ update_config_multiple_var() {
     done
 }
 
+file_process_from_env() {
+    local config_path=$1
+    local var_name=$2
+    local file_name=$3
+    local var_value=$4
+
+    if [ ! -z "$var_value" ]; then
+        echo -n "$var_value" > "${ZABBIX_INTERNAL_ENC_DIR}/$var_name"
+        file_name="${ZABBIX_INTERNAL_ENC_DIR}/${var_name}"
+    fi
+    update_config_var $config_path "$var_name" "$file_name"
+}
+
 # Check prerequisites for PostgreSQL database
 check_variables_postgresql() {
     file_env POSTGRES_USER
@@ -516,20 +531,17 @@ update_zbx_config() {
     update_config_var $ZBX_CONFIG "LoadModulePath" "$ZABBIX_USER_HOME_DIR/modules/"
     update_config_multiple_var $ZBX_CONFIG "LoadModule" "${ZBX_LOADMODULE}"
 
-    update_config_var $ZBX_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}"
-    update_config_var $ZBX_CONFIG "TLSCRLFile" "${ZBX_TLSCRLFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}" "${ZBX_TLSCA}"
+    file_process_from_env $ZBX_CONFIG "TLSCRLFile" "${ZBX_TLSCRLFILE}" "${ZBX_TLSCRL}"
 
-    update_config_var $ZBX_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}" "${ZBX_TLSCERT}"
     update_config_var $ZBX_CONFIG "TLSCipherAll" "${ZBX_TLSCIPHERALL}"
     update_config_var $ZBX_CONFIG "TLSCipherAll13" "${ZBX_TLSCIPHERALL13}"
     update_config_var $ZBX_CONFIG "TLSCipherCert" "${ZBX_TLSCIPHERCERT}"
     update_config_var $ZBX_CONFIG "TLSCipherCert13" "${ZBX_TLSCIPHERCERT13}"
     update_config_var $ZBX_CONFIG "TLSCipherPSK" "${ZBX_TLSCIPHERPSK}"
     update_config_var $ZBX_CONFIG "TLSCipherPSK13" "${ZBX_TLSCIPHERPSK13}"
-    update_config_var $ZBX_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}"
-
-    update_config_var $ZBX_CONFIG "TLSPSKIdentity" "${ZBX_TLSPSKIDENTITY}"
-    update_config_var $ZBX_CONFIG "TLSPSKFile" "${ZBX_TLSPSKFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}" "${ZBX_TLSKEY}"
 
     update_config_var $ZBX_CONFIG "ServiceManagerSyncFrequency" "${ZBX_SERVICEMANAGERSYNCFREQUENCY}"
 
diff --git a/Dockerfiles/web-service/README.md b/Dockerfiles/web-service/README.md
index a44a45ca9..9f34ecf73 100644
--- a/Dockerfiles/web-service/README.md
+++ b/Dockerfiles/web-service/README.md
@@ -91,8 +91,11 @@ Additionally the image allows to specify many other environment variables listed
 ```
 ZBX_TLSACCEPT=unencrypted
 ZBX_TLSCAFILE=
+ZBX_TLSCA=
 ZBX_TLSCERTFILE=
+ZBX_TLSCERT=
 ZBX_TLSKEYFILE=
+ZBX_TLSKEY=
 ZBX_IGNOREURLCERTERRORS=0
 ```
 
@@ -104,7 +107,7 @@ Please use official documentation for [``zabbix_web_service.conf``](https://www.
 
 ### ``/var/lib/zabbix/enc``
 
-The volume is used to store TLS related files. These file names are specified using ``ZBX_TLSCAFILE``, ``ZBX_TLSCERTFILE`` and ``ZBX_TLSKEY_FILE`` variables.
+The volume is used to store TLS related files. These file names are specified using ``ZBX_TLSCAFILE``, ``ZBX_TLSCERTFILE`` and ``ZBX_TLSKEYFILE`` variables. Additionally it is possible to use environment variables ``ZBX_TLSCA``, ``ZBX_TLSCERT`` and ``ZBX_TLSKEY`` with plaintext values.
 
 # The image variants
 
diff --git a/Dockerfiles/web-service/alpine/Dockerfile b/Dockerfiles/web-service/alpine/Dockerfile
index 59fc389b8..bc16cee5d 100644
--- a/Dockerfiles/web-service/alpine/Dockerfile
+++ b/Dockerfiles/web-service/alpine/Dockerfile
@@ -51,6 +51,8 @@ RUN set -eux && \
         zabbix && \
     mkdir -p /etc/zabbix && \
     mkdir -p /var/lib/zabbix && \
+    mkdir -p /var/lib/zabbix/enc && \
+    mkdir -p /var/lib/zabbix/enc_internal && \
     chown --quiet -R zabbix:root /etc/zabbix/ /var/lib/zabbix/ && \
     chgrp -R 0 /etc/zabbix/ /var/lib/zabbix/ && \
     chmod -R g=u /etc/zabbix/ /var/lib/zabbix/
diff --git a/Dockerfiles/web-service/alpine/docker-entrypoint.sh b/Dockerfiles/web-service/alpine/docker-entrypoint.sh
index 4ba72eeab..b86938b0b 100755
--- a/Dockerfiles/web-service/alpine/docker-entrypoint.sh
+++ b/Dockerfiles/web-service/alpine/docker-entrypoint.sh
@@ -14,6 +14,8 @@ fi
 ZABBIX_USER_HOME_DIR="/var/lib/zabbix"
 # Configuration files directory
 ZABBIX_ETC_DIR="/etc/zabbix"
+# Internal directory for TLS related files, used when TLS*File specified as plain text values
+ZABBIX_INTERNAL_ENC_DIR="${ZABBIX_USER_HOME_DIR}/enc_internal"
 
 escape_spec_char() {
     local var_value=$1
@@ -84,6 +86,19 @@ update_config_var() {
 
 }
 
+file_process_from_env() {
+    local config_path=$1
+    local var_name=$2
+    local file_name=$3
+    local var_value=$4
+
+    if [ ! -z "$var_value" ]; then
+        echo -n "$var_value" > "${ZABBIX_INTERNAL_ENC_DIR}/$var_name"
+        file_name="${ZABBIX_INTERNAL_ENC_DIR}/${var_name}"
+    fi
+    update_config_var $config_path "$var_name" "$file_name"
+}
+
 prepare_zbx_web_service_config() {
     echo "** Preparing Zabbix web service configuration file"
     ZBX_CONFIG=$ZABBIX_ETC_DIR/zabbix_web_service.conf
@@ -101,10 +116,10 @@ prepare_zbx_web_service_config() {
     update_config_var $ZBX_CONFIG "Timeout" "${ZBX_TIMEOUT}"
 
     update_config_var $ZBX_CONFIG "TLSAccept" "${ZBX_TLSACCEPT}"
-    update_config_var $ZBX_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}" "${ZBX_TLSCA}"
 
-    update_config_var $ZBX_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}"
-    update_config_var $ZBX_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}" "${ZBX_TLSCERT}"
+    file_process_from_env $ZBX_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}" "${ZBX_TLSKEY}"
 
     update_config_var $ZBX_CONFIG "IgnoreURLCertErrors" "${ZBX_IGNOREURLCERTERRORS}"
 }
diff --git a/Dockerfiles/web-service/centos/Dockerfile b/Dockerfiles/web-service/centos/Dockerfile
index 148cb9028..7aa7c66c9 100644
--- a/Dockerfiles/web-service/centos/Dockerfile
+++ b/Dockerfiles/web-service/centos/Dockerfile
@@ -71,6 +71,7 @@ RUN --mount=type=tmpfs,target=/var/lib/dnf/ \
     mkdir -p /etc/zabbix && \
     mkdir -p /var/lib/zabbix && \
     mkdir -p /var/lib/zabbix/enc && \
+    mkdir -p /var/lib/zabbix/enc_internal && \
     chown --quiet -R zabbix:root /etc/zabbix/ /var/lib/zabbix/ && \
     chgrp -R 0 /etc/zabbix/ /var/lib/zabbix/ && \
     chmod -R g=u /etc/zabbix/ /var/lib/zabbix/ && \
diff --git a/Dockerfiles/web-service/centos/docker-entrypoint.sh b/Dockerfiles/web-service/centos/docker-entrypoint.sh
index 4ba72eeab..b86938b0b 100755
--- a/Dockerfiles/web-service/centos/docker-entrypoint.sh
+++ b/Dockerfiles/web-service/centos/docker-entrypoint.sh
@@ -14,6 +14,8 @@ fi
 ZABBIX_USER_HOME_DIR="/var/lib/zabbix"
 # Configuration files directory
 ZABBIX_ETC_DIR="/etc/zabbix"
+# Internal directory for TLS related files, used when TLS*File specified as plain text values
+ZABBIX_INTERNAL_ENC_DIR="${ZABBIX_USER_HOME_DIR}/enc_internal"
 
 escape_spec_char() {
     local var_value=$1
@@ -84,6 +86,19 @@ update_config_var() {
 
 }
 
+file_process_from_env() {
+    local config_path=$1
+    local var_name=$2
+    local file_name=$3
+    local var_value=$4
+
+    if [ ! -z "$var_value" ]; then
+        echo -n "$var_value" > "${ZABBIX_INTERNAL_ENC_DIR}/$var_name"
+        file_name="${ZABBIX_INTERNAL_ENC_DIR}/${var_name}"
+    fi
+    update_config_var $config_path "$var_name" "$file_name"
+}
+
 prepare_zbx_web_service_config() {
     echo "** Preparing Zabbix web service configuration file"
     ZBX_CONFIG=$ZABBIX_ETC_DIR/zabbix_web_service.conf
@@ -101,10 +116,10 @@ prepare_zbx_web_service_config() {
     update_config_var $ZBX_CONFIG "Timeout" "${ZBX_TIMEOUT}"
 
     update_config_var $ZBX_CONFIG "TLSAccept" "${ZBX_TLSACCEPT}"
-    update_config_var $ZBX_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}" "${ZBX_TLSCA}"
 
-    update_config_var $ZBX_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}"
-    update_config_var $ZBX_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}" "${ZBX_TLSCERT}"
+    file_process_from_env $ZBX_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}" "${ZBX_TLSKEY}"
 
     update_config_var $ZBX_CONFIG "IgnoreURLCertErrors" "${ZBX_IGNOREURLCERTERRORS}"
 }
diff --git a/Dockerfiles/web-service/ol/Dockerfile b/Dockerfiles/web-service/ol/Dockerfile
index acaaa9c00..c13caac96 100644
--- a/Dockerfiles/web-service/ol/Dockerfile
+++ b/Dockerfiles/web-service/ol/Dockerfile
@@ -60,6 +60,7 @@ RUN --mount=type=tmpfs,target=/var/lib/dnf/ \
     mkdir -p /etc/zabbix && \
     mkdir -p /var/lib/zabbix && \
     mkdir -p /var/lib/zabbix/enc && \
+    mkdir -p /var/lib/zabbix/enc_internal && \
     chown --quiet -R zabbix:root /etc/zabbix/ /var/lib/zabbix/ && \
     chgrp -R 0 /etc/zabbix/ /var/lib/zabbix/ && \
     chmod -R g=u /etc/zabbix/ /var/lib/zabbix/ && \
diff --git a/Dockerfiles/web-service/ol/docker-entrypoint.sh b/Dockerfiles/web-service/ol/docker-entrypoint.sh
index 4ba72eeab..b86938b0b 100755
--- a/Dockerfiles/web-service/ol/docker-entrypoint.sh
+++ b/Dockerfiles/web-service/ol/docker-entrypoint.sh
@@ -14,6 +14,8 @@ fi
 ZABBIX_USER_HOME_DIR="/var/lib/zabbix"
 # Configuration files directory
 ZABBIX_ETC_DIR="/etc/zabbix"
+# Internal directory for TLS related files, used when TLS*File specified as plain text values
+ZABBIX_INTERNAL_ENC_DIR="${ZABBIX_USER_HOME_DIR}/enc_internal"
 
 escape_spec_char() {
     local var_value=$1
@@ -84,6 +86,19 @@ update_config_var() {
 
 }
 
+file_process_from_env() {
+    local config_path=$1
+    local var_name=$2
+    local file_name=$3
+    local var_value=$4
+
+    if [ ! -z "$var_value" ]; then
+        echo -n "$var_value" > "${ZABBIX_INTERNAL_ENC_DIR}/$var_name"
+        file_name="${ZABBIX_INTERNAL_ENC_DIR}/${var_name}"
+    fi
+    update_config_var $config_path "$var_name" "$file_name"
+}
+
 prepare_zbx_web_service_config() {
     echo "** Preparing Zabbix web service configuration file"
     ZBX_CONFIG=$ZABBIX_ETC_DIR/zabbix_web_service.conf
@@ -101,10 +116,10 @@ prepare_zbx_web_service_config() {
     update_config_var $ZBX_CONFIG "Timeout" "${ZBX_TIMEOUT}"
 
     update_config_var $ZBX_CONFIG "TLSAccept" "${ZBX_TLSACCEPT}"
-    update_config_var $ZBX_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}" "${ZBX_TLSCA}"
 
-    update_config_var $ZBX_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}"
-    update_config_var $ZBX_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}" "${ZBX_TLSCERT}"
+    file_process_from_env $ZBX_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}" "${ZBX_TLSKEY}"
 
     update_config_var $ZBX_CONFIG "IgnoreURLCertErrors" "${ZBX_IGNOREURLCERTERRORS}"
 }
diff --git a/Dockerfiles/web-service/rhel/Dockerfile b/Dockerfiles/web-service/rhel/Dockerfile
index 8e625d6a6..c56619c3d 100644
--- a/Dockerfiles/web-service/rhel/Dockerfile
+++ b/Dockerfiles/web-service/rhel/Dockerfile
@@ -91,6 +91,7 @@ RUN --mount=type=tmpfs,target=/var/lib/dnf/ \
     mkdir -p /etc/zabbix && \
     mkdir -p /var/lib/zabbix && \
     mkdir -p /var/lib/zabbix/enc && \
+    mkdir -p /var/lib/zabbix/enc_internal && \
     chown --quiet -R zabbix:root /etc/zabbix/ /var/lib/zabbix/ && \
     chgrp -R 0 /etc/zabbix/ /var/lib/zabbix/ && \
     chmod -R g=u /etc/zabbix/ /var/lib/zabbix/ && \
diff --git a/Dockerfiles/web-service/rhel/docker-entrypoint.sh b/Dockerfiles/web-service/rhel/docker-entrypoint.sh
index 4ba72eeab..b86938b0b 100755
--- a/Dockerfiles/web-service/rhel/docker-entrypoint.sh
+++ b/Dockerfiles/web-service/rhel/docker-entrypoint.sh
@@ -14,6 +14,8 @@ fi
 ZABBIX_USER_HOME_DIR="/var/lib/zabbix"
 # Configuration files directory
 ZABBIX_ETC_DIR="/etc/zabbix"
+# Internal directory for TLS related files, used when TLS*File specified as plain text values
+ZABBIX_INTERNAL_ENC_DIR="${ZABBIX_USER_HOME_DIR}/enc_internal"
 
 escape_spec_char() {
     local var_value=$1
@@ -84,6 +86,19 @@ update_config_var() {
 
 }
 
+file_process_from_env() {
+    local config_path=$1
+    local var_name=$2
+    local file_name=$3
+    local var_value=$4
+
+    if [ ! -z "$var_value" ]; then
+        echo -n "$var_value" > "${ZABBIX_INTERNAL_ENC_DIR}/$var_name"
+        file_name="${ZABBIX_INTERNAL_ENC_DIR}/${var_name}"
+    fi
+    update_config_var $config_path "$var_name" "$file_name"
+}
+
 prepare_zbx_web_service_config() {
     echo "** Preparing Zabbix web service configuration file"
     ZBX_CONFIG=$ZABBIX_ETC_DIR/zabbix_web_service.conf
@@ -101,10 +116,10 @@ prepare_zbx_web_service_config() {
     update_config_var $ZBX_CONFIG "Timeout" "${ZBX_TIMEOUT}"
 
     update_config_var $ZBX_CONFIG "TLSAccept" "${ZBX_TLSACCEPT}"
-    update_config_var $ZBX_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}" "${ZBX_TLSCA}"
 
-    update_config_var $ZBX_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}"
-    update_config_var $ZBX_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}" "${ZBX_TLSCERT}"
+    file_process_from_env $ZBX_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}" "${ZBX_TLSKEY}"
 
     update_config_var $ZBX_CONFIG "IgnoreURLCertErrors" "${ZBX_IGNOREURLCERTERRORS}"
 }
diff --git a/Dockerfiles/web-service/ubuntu/Dockerfile b/Dockerfiles/web-service/ubuntu/Dockerfile
index 1c3ad0986..24e424a17 100644
--- a/Dockerfiles/web-service/ubuntu/Dockerfile
+++ b/Dockerfiles/web-service/ubuntu/Dockerfile
@@ -65,6 +65,7 @@ RUN --mount=type=cache,target=/var/lib/apt/,sharing=locked \
     mkdir -p /etc/zabbix && \
     mkdir -p /var/lib/zabbix && \
     mkdir -p /var/lib/zabbix/enc && \
+    mkdir -p /var/lib/zabbix/enc_internal && \
     chown --quiet -R zabbix:root /etc/zabbix/ /var/lib/zabbix/ && \
     chgrp -R 0 /etc/zabbix/ /var/lib/zabbix/ && \
     chmod -R g=u /etc/zabbix/ /var/lib/zabbix/ && \
diff --git a/Dockerfiles/web-service/ubuntu/docker-entrypoint.sh b/Dockerfiles/web-service/ubuntu/docker-entrypoint.sh
index 4ba72eeab..b86938b0b 100755
--- a/Dockerfiles/web-service/ubuntu/docker-entrypoint.sh
+++ b/Dockerfiles/web-service/ubuntu/docker-entrypoint.sh
@@ -14,6 +14,8 @@ fi
 ZABBIX_USER_HOME_DIR="/var/lib/zabbix"
 # Configuration files directory
 ZABBIX_ETC_DIR="/etc/zabbix"
+# Internal directory for TLS related files, used when TLS*File specified as plain text values
+ZABBIX_INTERNAL_ENC_DIR="${ZABBIX_USER_HOME_DIR}/enc_internal"
 
 escape_spec_char() {
     local var_value=$1
@@ -84,6 +86,19 @@ update_config_var() {
 
 }
 
+file_process_from_env() {
+    local config_path=$1
+    local var_name=$2
+    local file_name=$3
+    local var_value=$4
+
+    if [ ! -z "$var_value" ]; then
+        echo -n "$var_value" > "${ZABBIX_INTERNAL_ENC_DIR}/$var_name"
+        file_name="${ZABBIX_INTERNAL_ENC_DIR}/${var_name}"
+    fi
+    update_config_var $config_path "$var_name" "$file_name"
+}
+
 prepare_zbx_web_service_config() {
     echo "** Preparing Zabbix web service configuration file"
     ZBX_CONFIG=$ZABBIX_ETC_DIR/zabbix_web_service.conf
@@ -101,10 +116,10 @@ prepare_zbx_web_service_config() {
     update_config_var $ZBX_CONFIG "Timeout" "${ZBX_TIMEOUT}"
 
     update_config_var $ZBX_CONFIG "TLSAccept" "${ZBX_TLSACCEPT}"
-    update_config_var $ZBX_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}" "${ZBX_TLSCA}"
 
-    update_config_var $ZBX_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}"
-    update_config_var $ZBX_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}" "${ZBX_TLSCERT}"
+    file_process_from_env $ZBX_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}" "${ZBX_TLSKEY}"
 
     update_config_var $ZBX_CONFIG "IgnoreURLCertErrors" "${ZBX_IGNOREURLCERTERRORS}"
 }
diff --git a/env_vars/.env_agent b/env_vars/.env_agent
index eab36e2cc..b99075d27 100644
--- a/env_vars/.env_agent
+++ b/env_vars/.env_agent
@@ -28,12 +28,17 @@
 # ZBX_TLSCONNECT=unencrypted
 # ZBX_TLSACCEPT=unencrypted
 # ZBX_TLSCAFILE=
+# ZBX_TLSCA=
 # ZBX_TLSCRLFILE=
+# ZBX_TLSCRL=
 # ZBX_TLSSERVERCERTISSUER=
 # ZBX_TLSSERVERCERTSUBJECT=
 # ZBX_TLSCERTFILE=
+# ZBX_TLSCERT=
 # ZBX_TLSKEYFILE=
+# ZBX_TLSKEY=
 # ZBX_TLSPSKIDENTITY=
 # ZBX_TLSPSKFILE=
+# ZBX_TLSPSK=
 # ZBX_DENYKEY=system.run[*]
 # ZBX_ALLOWKEY=
diff --git a/env_vars/.env_prx b/env_vars/.env_prx
index fe4f7dbf4..d3b050ecb 100644
--- a/env_vars/.env_prx
+++ b/env_vars/.env_prx
@@ -48,13 +48,18 @@
 # ZBX_TLSCONNECT=unencrypted
 # ZBX_TLSACCEPT=unencrypted
 # ZBX_TLSCAFILE=
+# ZBX_TLSCA=
 # ZBX_TLSCRLFILE=
+# ZBX_TLSCRL=
 # ZBX_TLSSERVERCERTISSUER=
 # ZBX_TLSSERVERCERTSUBJECT=
 # ZBX_TLSCERTFILE=
+# ZBX_TLSCERT=
 # ZBX_TLSKEYFILE=
+# ZBX_TLSKEY=
 # ZBX_TLSPSKIDENTITY=
 # ZBX_TLSPSKFILE=
+# ZBX_TLSPSK=
 # ZBX_VAULTDBPATH=
 # ZBX_VAULTURL=https://127.0.0.1:8200
 # VAULT_TOKEN=
diff --git a/env_vars/.env_srv b/env_vars/.env_srv
index a53fece19..351ab77ed 100644
--- a/env_vars/.env_srv
+++ b/env_vars/.env_srv
@@ -65,9 +65,13 @@ ZBX_ENABLE_SNMP_TRAPS=true
 # ZBX_PROXYDATAFREQUENCY=1
 # ZBX_LOADMODULE="dummy1.so,dummy2.so,dummy10.so"
 # ZBX_TLSCAFILE=
+# ZBX_TLSCA=
 # ZBX_TLSCRLFILE=
+# ZBX_TLSCRL=
 # ZBX_TLSCERTFILE=
+# ZBX_TLSCERT=
 # ZBX_TLSKEYFILE=
+# ZBX_TLSKEY=
 # ZBX_VAULTDBPATH=
 # ZBX_VAULTURL=https://127.0.0.1:8200
 # VAULT_TOKEN=