diff --git a/Dockerfiles/agent/README.md b/Dockerfiles/agent/README.md
index 425c5ca6e..573767a98 100644
--- a/Dockerfiles/agent/README.md
+++ b/Dockerfiles/agent/README.md
@@ -151,13 +151,18 @@ ZBX_UNSAFEUSERPARAMETERS=0
 ZBX_TLSCONNECT=unencrypted
 ZBX_TLSACCEPT=unencrypted
 ZBX_TLSCAFILE=
+ZBX_TLSCA=
 ZBX_TLSCRLFILE=
+ZBX_TLSCRL=
 ZBX_TLSSERVERCERTISSUER=
 ZBX_TLSSERVERCERTSUBJECT=
 ZBX_TLSCERTFILE=
+ZBX_TLSCERT=
 ZBX_TLSKEYFILE=
+ZBX_TLSKEY=
 ZBX_TLSPSKIDENTITY=
 ZBX_TLSPSKFILE=
+ZBX_TLSPSK=
 ZBX_TLSCIPHERALL= # Available since 4.4.7
 ZBX_TLSCIPHERALL13= # Available since 4.4.7
 ZBX_TLSCIPHERCERT= # Available since 4.4.7
@@ -186,7 +191,7 @@ The volume allows load additional modules and extend Zabbix agent using ``LoadMo
 
 ### ``/var/lib/zabbix/enc``
 
-The volume is used to store TLS related files. These file names are specified using ``ZBX_TLSCAFILE``, ``ZBX_TLSCRLFILE``, ``ZBX_TLSKEY_FILE`` and ``ZBX_TLSPSKFILE`` variables.
+The volume is used to store TLS related files. These file names are specified using ``ZBX_TLSCAFILE``, ``ZBX_TLSCRLFILE``, ``ZBX_TLSCERTFILE``, ``ZBX_TLSKEYFILE`` and ``ZBX_TLSPSKFILE`` variables. Additionally it is possible to use environment variables ``ZBX_TLSCA``, ``ZBX_TLSCRL``, ``ZBX_TLSCERT``, ``ZBX_TLSKEY`` and ``ZBX_TLSPSK`` with plaintext values.
 
 # The image variants
 
diff --git a/Dockerfiles/agent/alpine/Dockerfile b/Dockerfiles/agent/alpine/Dockerfile
index ddd578f36..85ed155a9 100644
--- a/Dockerfiles/agent/alpine/Dockerfile
+++ b/Dockerfiles/agent/alpine/Dockerfile
@@ -61,6 +61,7 @@ RUN set -eux && \
     mkdir -p /etc/zabbix/zabbix_agentd.d && \
     mkdir -p /var/lib/zabbix && \
     mkdir -p /var/lib/zabbix/enc && \
+    mkdir -p /var/lib/zabbix/enc_internal && \
     mkdir -p /var/lib/zabbix/modules && \
     chown --quiet -R zabbix:root /etc/zabbix/ /var/lib/zabbix/ && \
     chgrp -R 0 /etc/zabbix/ /var/lib/zabbix/ && \
diff --git a/Dockerfiles/agent/alpine/docker-entrypoint.sh b/Dockerfiles/agent/alpine/docker-entrypoint.sh
index e2bcb52f1..c01f3ca19 100755
--- a/Dockerfiles/agent/alpine/docker-entrypoint.sh
+++ b/Dockerfiles/agent/alpine/docker-entrypoint.sh
@@ -20,6 +20,8 @@ fi
 ZABBIX_USER_HOME_DIR="/var/lib/zabbix"
 # Configuration files directory
 ZABBIX_ETC_DIR="/etc/zabbix"
+# Internal directory for TLS related files, used when TLS*File specified as plain text values
+ZABBIX_INTERNAL_ENC_DIR="${ZABBIX_USER_HOME_DIR}/enc_internal"
 
 escape_spec_char() {
     local var_value=$1
@@ -112,6 +114,19 @@ update_config_multiple_var() {
     done
 }
 
+file_process_from_env() {
+    local config_path=$1
+    local var_name=$2
+    local file_name=$3
+    local var_value=$4
+
+    if [ ! -z "$var_value" ]; then
+        echo -n "$var_value" > "${ZABBIX_INTERNAL_ENC_DIR}/$var_name"
+        file_name="${ZABBIX_INTERNAL_ENC_DIR}/${var_name}"
+    fi
+    update_config_var $config_path "$var_name" "$file_name"
+}
+
 prepare_zbx_agent_config() {
     echo "** Preparing Zabbix agent configuration file"
     ZBX_AGENT_CONFIG=$ZABBIX_ETC_DIR/zabbix_agentd.conf
@@ -176,20 +191,20 @@ prepare_zbx_agent_config() {
     update_config_multiple_var $ZBX_AGENT_CONFIG "LoadModule" "${ZBX_LOADMODULE}"
     update_config_var $ZBX_AGENT_CONFIG "TLSConnect" "${ZBX_TLSCONNECT}"
     update_config_var $ZBX_AGENT_CONFIG "TLSAccept" "${ZBX_TLSACCEPT}"
-    update_config_var $ZBX_AGENT_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}"
-    update_config_var $ZBX_AGENT_CONFIG "TLSCRLFile" "${ZBX_TLSCRLFILE}"
+    file_process_from_env $ZBX_AGENT_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}" "${ZBX_TLSCA}"
+    file_process_from_env $ZBX_AGENT_CONFIG "TLSCRLFile" "${ZBX_TLSCRLFILE}" "${ZBX_TLSCRL}"
     update_config_var $ZBX_AGENT_CONFIG "TLSServerCertIssuer" "${ZBX_TLSSERVERCERTISSUER}"
     update_config_var $ZBX_AGENT_CONFIG "TLSServerCertSubject" "${ZBX_TLSSERVERCERTSUBJECT}"
-    update_config_var $ZBX_AGENT_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}"
+    file_process_from_env $ZBX_AGENT_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}" "${ZBX_TLSCERT}"
     update_config_var $ZBX_AGENT_CONFIG "TLSCipherAll" "${ZBX_TLSCIPHERALL}"
     update_config_var $ZBX_AGENT_CONFIG "TLSCipherAll13" "${ZBX_TLSCIPHERALL13}"
     update_config_var $ZBX_AGENT_CONFIG "TLSCipherCert" "${ZBX_TLSCIPHERCERT}"
     update_config_var $ZBX_AGENT_CONFIG "TLSCipherCert13" "${ZBX_TLSCIPHERCERT13}"
     update_config_var $ZBX_AGENT_CONFIG "TLSCipherPSK" "${ZBX_TLSCIPHERPSK}"
     update_config_var $ZBX_AGENT_CONFIG "TLSCipherPSK13" "${ZBX_TLSCIPHERPSK13}"
-    update_config_var $ZBX_AGENT_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}"
+    file_process_from_env $ZBX_AGENT_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}" "${ZBX_TLSKEY}"
     update_config_var $ZBX_AGENT_CONFIG "TLSPSKIdentity" "${ZBX_TLSPSKIDENTITY}"
-    update_config_var $ZBX_AGENT_CONFIG "TLSPSKFile" "${ZBX_TLSPSKFILE}"
+    file_process_from_env $ZBX_AGENT_CONFIG "TLSPSKFile" "${ZBX_TLSPSKFILE}" "${ZBX_TLSPSK}"
 
     update_config_multiple_var $ZBX_AGENT_CONFIG "DenyKey" "${ZBX_DENYKEY}"
     update_config_multiple_var $ZBX_AGENT_CONFIG "AllowKey" "${ZBX_ALLOWKEY}"
diff --git a/Dockerfiles/agent/centos/Dockerfile b/Dockerfiles/agent/centos/Dockerfile
index f4992fd9c..0cfc9f37a 100644
--- a/Dockerfiles/agent/centos/Dockerfile
+++ b/Dockerfiles/agent/centos/Dockerfile
@@ -64,6 +64,7 @@ RUN --mount=type=tmpfs,target=/var/lib/dnf/ \
     mkdir -p /etc/zabbix/zabbix_agentd.d && \
     mkdir -p /var/lib/zabbix && \
     mkdir -p /var/lib/zabbix/enc && \
+    mkdir -p /var/lib/zabbix/enc_internal && \
     mkdir -p /var/lib/zabbix/modules && \
     chown --quiet -R zabbix:root /etc/zabbix/ /var/lib/zabbix/ && \
     chgrp -R 0 /etc/zabbix/ /var/lib/zabbix/ && \
diff --git a/Dockerfiles/agent/centos/docker-entrypoint.sh b/Dockerfiles/agent/centos/docker-entrypoint.sh
index e2bcb52f1..c01f3ca19 100755
--- a/Dockerfiles/agent/centos/docker-entrypoint.sh
+++ b/Dockerfiles/agent/centos/docker-entrypoint.sh
@@ -20,6 +20,8 @@ fi
 ZABBIX_USER_HOME_DIR="/var/lib/zabbix"
 # Configuration files directory
 ZABBIX_ETC_DIR="/etc/zabbix"
+# Internal directory for TLS related files, used when TLS*File specified as plain text values
+ZABBIX_INTERNAL_ENC_DIR="${ZABBIX_USER_HOME_DIR}/enc_internal"
 
 escape_spec_char() {
     local var_value=$1
@@ -112,6 +114,19 @@ update_config_multiple_var() {
     done
 }
 
+file_process_from_env() {
+    local config_path=$1
+    local var_name=$2
+    local file_name=$3
+    local var_value=$4
+
+    if [ ! -z "$var_value" ]; then
+        echo -n "$var_value" > "${ZABBIX_INTERNAL_ENC_DIR}/$var_name"
+        file_name="${ZABBIX_INTERNAL_ENC_DIR}/${var_name}"
+    fi
+    update_config_var $config_path "$var_name" "$file_name"
+}
+
 prepare_zbx_agent_config() {
     echo "** Preparing Zabbix agent configuration file"
     ZBX_AGENT_CONFIG=$ZABBIX_ETC_DIR/zabbix_agentd.conf
@@ -176,20 +191,20 @@ prepare_zbx_agent_config() {
     update_config_multiple_var $ZBX_AGENT_CONFIG "LoadModule" "${ZBX_LOADMODULE}"
     update_config_var $ZBX_AGENT_CONFIG "TLSConnect" "${ZBX_TLSCONNECT}"
     update_config_var $ZBX_AGENT_CONFIG "TLSAccept" "${ZBX_TLSACCEPT}"
-    update_config_var $ZBX_AGENT_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}"
-    update_config_var $ZBX_AGENT_CONFIG "TLSCRLFile" "${ZBX_TLSCRLFILE}"
+    file_process_from_env $ZBX_AGENT_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}" "${ZBX_TLSCA}"
+    file_process_from_env $ZBX_AGENT_CONFIG "TLSCRLFile" "${ZBX_TLSCRLFILE}" "${ZBX_TLSCRL}"
     update_config_var $ZBX_AGENT_CONFIG "TLSServerCertIssuer" "${ZBX_TLSSERVERCERTISSUER}"
     update_config_var $ZBX_AGENT_CONFIG "TLSServerCertSubject" "${ZBX_TLSSERVERCERTSUBJECT}"
-    update_config_var $ZBX_AGENT_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}"
+    file_process_from_env $ZBX_AGENT_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}" "${ZBX_TLSCERT}"
     update_config_var $ZBX_AGENT_CONFIG "TLSCipherAll" "${ZBX_TLSCIPHERALL}"
     update_config_var $ZBX_AGENT_CONFIG "TLSCipherAll13" "${ZBX_TLSCIPHERALL13}"
     update_config_var $ZBX_AGENT_CONFIG "TLSCipherCert" "${ZBX_TLSCIPHERCERT}"
     update_config_var $ZBX_AGENT_CONFIG "TLSCipherCert13" "${ZBX_TLSCIPHERCERT13}"
     update_config_var $ZBX_AGENT_CONFIG "TLSCipherPSK" "${ZBX_TLSCIPHERPSK}"
     update_config_var $ZBX_AGENT_CONFIG "TLSCipherPSK13" "${ZBX_TLSCIPHERPSK13}"
-    update_config_var $ZBX_AGENT_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}"
+    file_process_from_env $ZBX_AGENT_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}" "${ZBX_TLSKEY}"
     update_config_var $ZBX_AGENT_CONFIG "TLSPSKIdentity" "${ZBX_TLSPSKIDENTITY}"
-    update_config_var $ZBX_AGENT_CONFIG "TLSPSKFile" "${ZBX_TLSPSKFILE}"
+    file_process_from_env $ZBX_AGENT_CONFIG "TLSPSKFile" "${ZBX_TLSPSKFILE}" "${ZBX_TLSPSK}"
 
     update_config_multiple_var $ZBX_AGENT_CONFIG "DenyKey" "${ZBX_DENYKEY}"
     update_config_multiple_var $ZBX_AGENT_CONFIG "AllowKey" "${ZBX_ALLOWKEY}"
diff --git a/Dockerfiles/agent/ol/Dockerfile b/Dockerfiles/agent/ol/Dockerfile
index 3815e06c0..a872914ec 100644
--- a/Dockerfiles/agent/ol/Dockerfile
+++ b/Dockerfiles/agent/ol/Dockerfile
@@ -67,6 +67,7 @@ RUN --mount=type=tmpfs,target=/var/lib/dnf/ \
     mkdir -p /etc/zabbix/zabbix_agentd.d && \
     mkdir -p /var/lib/zabbix && \
     mkdir -p /var/lib/zabbix/enc && \
+    mkdir -p /var/lib/zabbix/enc_internal && \
     mkdir -p /var/lib/zabbix/modules && \
     chown --quiet -R zabbix:root /etc/zabbix/ /var/lib/zabbix/ && \
     chgrp -R 0 /etc/zabbix/ /var/lib/zabbix/ && \
diff --git a/Dockerfiles/agent/ol/docker-entrypoint.sh b/Dockerfiles/agent/ol/docker-entrypoint.sh
index e2bcb52f1..c01f3ca19 100755
--- a/Dockerfiles/agent/ol/docker-entrypoint.sh
+++ b/Dockerfiles/agent/ol/docker-entrypoint.sh
@@ -20,6 +20,8 @@ fi
 ZABBIX_USER_HOME_DIR="/var/lib/zabbix"
 # Configuration files directory
 ZABBIX_ETC_DIR="/etc/zabbix"
+# Internal directory for TLS related files, used when TLS*File specified as plain text values
+ZABBIX_INTERNAL_ENC_DIR="${ZABBIX_USER_HOME_DIR}/enc_internal"
 
 escape_spec_char() {
     local var_value=$1
@@ -112,6 +114,19 @@ update_config_multiple_var() {
     done
 }
 
+file_process_from_env() {
+    local config_path=$1
+    local var_name=$2
+    local file_name=$3
+    local var_value=$4
+
+    if [ ! -z "$var_value" ]; then
+        echo -n "$var_value" > "${ZABBIX_INTERNAL_ENC_DIR}/$var_name"
+        file_name="${ZABBIX_INTERNAL_ENC_DIR}/${var_name}"
+    fi
+    update_config_var $config_path "$var_name" "$file_name"
+}
+
 prepare_zbx_agent_config() {
     echo "** Preparing Zabbix agent configuration file"
     ZBX_AGENT_CONFIG=$ZABBIX_ETC_DIR/zabbix_agentd.conf
@@ -176,20 +191,20 @@ prepare_zbx_agent_config() {
     update_config_multiple_var $ZBX_AGENT_CONFIG "LoadModule" "${ZBX_LOADMODULE}"
     update_config_var $ZBX_AGENT_CONFIG "TLSConnect" "${ZBX_TLSCONNECT}"
     update_config_var $ZBX_AGENT_CONFIG "TLSAccept" "${ZBX_TLSACCEPT}"
-    update_config_var $ZBX_AGENT_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}"
-    update_config_var $ZBX_AGENT_CONFIG "TLSCRLFile" "${ZBX_TLSCRLFILE}"
+    file_process_from_env $ZBX_AGENT_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}" "${ZBX_TLSCA}"
+    file_process_from_env $ZBX_AGENT_CONFIG "TLSCRLFile" "${ZBX_TLSCRLFILE}" "${ZBX_TLSCRL}"
     update_config_var $ZBX_AGENT_CONFIG "TLSServerCertIssuer" "${ZBX_TLSSERVERCERTISSUER}"
     update_config_var $ZBX_AGENT_CONFIG "TLSServerCertSubject" "${ZBX_TLSSERVERCERTSUBJECT}"
-    update_config_var $ZBX_AGENT_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}"
+    file_process_from_env $ZBX_AGENT_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}" "${ZBX_TLSCERT}"
     update_config_var $ZBX_AGENT_CONFIG "TLSCipherAll" "${ZBX_TLSCIPHERALL}"
     update_config_var $ZBX_AGENT_CONFIG "TLSCipherAll13" "${ZBX_TLSCIPHERALL13}"
     update_config_var $ZBX_AGENT_CONFIG "TLSCipherCert" "${ZBX_TLSCIPHERCERT}"
     update_config_var $ZBX_AGENT_CONFIG "TLSCipherCert13" "${ZBX_TLSCIPHERCERT13}"
     update_config_var $ZBX_AGENT_CONFIG "TLSCipherPSK" "${ZBX_TLSCIPHERPSK}"
     update_config_var $ZBX_AGENT_CONFIG "TLSCipherPSK13" "${ZBX_TLSCIPHERPSK13}"
-    update_config_var $ZBX_AGENT_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}"
+    file_process_from_env $ZBX_AGENT_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}" "${ZBX_TLSKEY}"
     update_config_var $ZBX_AGENT_CONFIG "TLSPSKIdentity" "${ZBX_TLSPSKIDENTITY}"
-    update_config_var $ZBX_AGENT_CONFIG "TLSPSKFile" "${ZBX_TLSPSKFILE}"
+    file_process_from_env $ZBX_AGENT_CONFIG "TLSPSKFile" "${ZBX_TLSPSKFILE}" "${ZBX_TLSPSK}"
 
     update_config_multiple_var $ZBX_AGENT_CONFIG "DenyKey" "${ZBX_DENYKEY}"
     update_config_multiple_var $ZBX_AGENT_CONFIG "AllowKey" "${ZBX_ALLOWKEY}"
diff --git a/Dockerfiles/agent/rhel/Dockerfile b/Dockerfiles/agent/rhel/Dockerfile
index 93e2d0b07..5ccb840c3 100644
--- a/Dockerfiles/agent/rhel/Dockerfile
+++ b/Dockerfiles/agent/rhel/Dockerfile
@@ -93,6 +93,7 @@ RUN --mount=type=tmpfs,target=/var/lib/dnf/ \
     mkdir -p /etc/zabbix/zabbix_agentd.d && \
     mkdir -p /var/lib/zabbix && \
     mkdir -p /var/lib/zabbix/enc && \
+    mkdir -p /var/lib/zabbix/enc_internal && \
     mkdir -p /var/lib/zabbix/modules && \
     chown --quiet -R zabbix:root /etc/zabbix/ /var/lib/zabbix/ && \
     chgrp -R 0 /etc/zabbix/ /var/lib/zabbix/ && \
diff --git a/Dockerfiles/agent/rhel/docker-entrypoint.sh b/Dockerfiles/agent/rhel/docker-entrypoint.sh
index e2bcb52f1..c01f3ca19 100755
--- a/Dockerfiles/agent/rhel/docker-entrypoint.sh
+++ b/Dockerfiles/agent/rhel/docker-entrypoint.sh
@@ -20,6 +20,8 @@ fi
 ZABBIX_USER_HOME_DIR="/var/lib/zabbix"
 # Configuration files directory
 ZABBIX_ETC_DIR="/etc/zabbix"
+# Internal directory for TLS related files, used when TLS*File specified as plain text values
+ZABBIX_INTERNAL_ENC_DIR="${ZABBIX_USER_HOME_DIR}/enc_internal"
 
 escape_spec_char() {
     local var_value=$1
@@ -112,6 +114,19 @@ update_config_multiple_var() {
     done
 }
 
+file_process_from_env() {
+    local config_path=$1
+    local var_name=$2
+    local file_name=$3
+    local var_value=$4
+
+    if [ ! -z "$var_value" ]; then
+        echo -n "$var_value" > "${ZABBIX_INTERNAL_ENC_DIR}/$var_name"
+        file_name="${ZABBIX_INTERNAL_ENC_DIR}/${var_name}"
+    fi
+    update_config_var $config_path "$var_name" "$file_name"
+}
+
 prepare_zbx_agent_config() {
     echo "** Preparing Zabbix agent configuration file"
     ZBX_AGENT_CONFIG=$ZABBIX_ETC_DIR/zabbix_agentd.conf
@@ -176,20 +191,20 @@ prepare_zbx_agent_config() {
     update_config_multiple_var $ZBX_AGENT_CONFIG "LoadModule" "${ZBX_LOADMODULE}"
     update_config_var $ZBX_AGENT_CONFIG "TLSConnect" "${ZBX_TLSCONNECT}"
     update_config_var $ZBX_AGENT_CONFIG "TLSAccept" "${ZBX_TLSACCEPT}"
-    update_config_var $ZBX_AGENT_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}"
-    update_config_var $ZBX_AGENT_CONFIG "TLSCRLFile" "${ZBX_TLSCRLFILE}"
+    file_process_from_env $ZBX_AGENT_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}" "${ZBX_TLSCA}"
+    file_process_from_env $ZBX_AGENT_CONFIG "TLSCRLFile" "${ZBX_TLSCRLFILE}" "${ZBX_TLSCRL}"
     update_config_var $ZBX_AGENT_CONFIG "TLSServerCertIssuer" "${ZBX_TLSSERVERCERTISSUER}"
     update_config_var $ZBX_AGENT_CONFIG "TLSServerCertSubject" "${ZBX_TLSSERVERCERTSUBJECT}"
-    update_config_var $ZBX_AGENT_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}"
+    file_process_from_env $ZBX_AGENT_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}" "${ZBX_TLSCERT}"
     update_config_var $ZBX_AGENT_CONFIG "TLSCipherAll" "${ZBX_TLSCIPHERALL}"
     update_config_var $ZBX_AGENT_CONFIG "TLSCipherAll13" "${ZBX_TLSCIPHERALL13}"
     update_config_var $ZBX_AGENT_CONFIG "TLSCipherCert" "${ZBX_TLSCIPHERCERT}"
     update_config_var $ZBX_AGENT_CONFIG "TLSCipherCert13" "${ZBX_TLSCIPHERCERT13}"
     update_config_var $ZBX_AGENT_CONFIG "TLSCipherPSK" "${ZBX_TLSCIPHERPSK}"
     update_config_var $ZBX_AGENT_CONFIG "TLSCipherPSK13" "${ZBX_TLSCIPHERPSK13}"
-    update_config_var $ZBX_AGENT_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}"
+    file_process_from_env $ZBX_AGENT_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}" "${ZBX_TLSKEY}"
     update_config_var $ZBX_AGENT_CONFIG "TLSPSKIdentity" "${ZBX_TLSPSKIDENTITY}"
-    update_config_var $ZBX_AGENT_CONFIG "TLSPSKFile" "${ZBX_TLSPSKFILE}"
+    file_process_from_env $ZBX_AGENT_CONFIG "TLSPSKFile" "${ZBX_TLSPSKFILE}" "${ZBX_TLSPSK}"
 
     update_config_multiple_var $ZBX_AGENT_CONFIG "DenyKey" "${ZBX_DENYKEY}"
     update_config_multiple_var $ZBX_AGENT_CONFIG "AllowKey" "${ZBX_ALLOWKEY}"
diff --git a/Dockerfiles/agent/ubuntu/Dockerfile b/Dockerfiles/agent/ubuntu/Dockerfile
index feff0339e..27658c628 100644
--- a/Dockerfiles/agent/ubuntu/Dockerfile
+++ b/Dockerfiles/agent/ubuntu/Dockerfile
@@ -60,6 +60,7 @@ RUN --mount=type=cache,target=/var/lib/apt/,sharing=locked \
     mkdir -p /etc/zabbix/zabbix_agentd.d && \
     mkdir -p /var/lib/zabbix && \
     mkdir -p /var/lib/zabbix/enc && \
+    mkdir -p /var/lib/zabbix/enc_internal && \
     mkdir -p /var/lib/zabbix/modules && \
     chown --quiet -R zabbix:root /etc/zabbix/ /var/lib/zabbix/ && \
     chgrp -R 0 /etc/zabbix/ /var/lib/zabbix/ && \
diff --git a/Dockerfiles/agent/ubuntu/docker-entrypoint.sh b/Dockerfiles/agent/ubuntu/docker-entrypoint.sh
index e2bcb52f1..c01f3ca19 100755
--- a/Dockerfiles/agent/ubuntu/docker-entrypoint.sh
+++ b/Dockerfiles/agent/ubuntu/docker-entrypoint.sh
@@ -20,6 +20,8 @@ fi
 ZABBIX_USER_HOME_DIR="/var/lib/zabbix"
 # Configuration files directory
 ZABBIX_ETC_DIR="/etc/zabbix"
+# Internal directory for TLS related files, used when TLS*File specified as plain text values
+ZABBIX_INTERNAL_ENC_DIR="${ZABBIX_USER_HOME_DIR}/enc_internal"
 
 escape_spec_char() {
     local var_value=$1
@@ -112,6 +114,19 @@ update_config_multiple_var() {
     done
 }
 
+file_process_from_env() {
+    local config_path=$1
+    local var_name=$2
+    local file_name=$3
+    local var_value=$4
+
+    if [ ! -z "$var_value" ]; then
+        echo -n "$var_value" > "${ZABBIX_INTERNAL_ENC_DIR}/$var_name"
+        file_name="${ZABBIX_INTERNAL_ENC_DIR}/${var_name}"
+    fi
+    update_config_var $config_path "$var_name" "$file_name"
+}
+
 prepare_zbx_agent_config() {
     echo "** Preparing Zabbix agent configuration file"
     ZBX_AGENT_CONFIG=$ZABBIX_ETC_DIR/zabbix_agentd.conf
@@ -176,20 +191,20 @@ prepare_zbx_agent_config() {
     update_config_multiple_var $ZBX_AGENT_CONFIG "LoadModule" "${ZBX_LOADMODULE}"
     update_config_var $ZBX_AGENT_CONFIG "TLSConnect" "${ZBX_TLSCONNECT}"
     update_config_var $ZBX_AGENT_CONFIG "TLSAccept" "${ZBX_TLSACCEPT}"
-    update_config_var $ZBX_AGENT_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}"
-    update_config_var $ZBX_AGENT_CONFIG "TLSCRLFile" "${ZBX_TLSCRLFILE}"
+    file_process_from_env $ZBX_AGENT_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}" "${ZBX_TLSCA}"
+    file_process_from_env $ZBX_AGENT_CONFIG "TLSCRLFile" "${ZBX_TLSCRLFILE}" "${ZBX_TLSCRL}"
     update_config_var $ZBX_AGENT_CONFIG "TLSServerCertIssuer" "${ZBX_TLSSERVERCERTISSUER}"
     update_config_var $ZBX_AGENT_CONFIG "TLSServerCertSubject" "${ZBX_TLSSERVERCERTSUBJECT}"
-    update_config_var $ZBX_AGENT_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}"
+    file_process_from_env $ZBX_AGENT_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}" "${ZBX_TLSCERT}"
     update_config_var $ZBX_AGENT_CONFIG "TLSCipherAll" "${ZBX_TLSCIPHERALL}"
     update_config_var $ZBX_AGENT_CONFIG "TLSCipherAll13" "${ZBX_TLSCIPHERALL13}"
     update_config_var $ZBX_AGENT_CONFIG "TLSCipherCert" "${ZBX_TLSCIPHERCERT}"
     update_config_var $ZBX_AGENT_CONFIG "TLSCipherCert13" "${ZBX_TLSCIPHERCERT13}"
     update_config_var $ZBX_AGENT_CONFIG "TLSCipherPSK" "${ZBX_TLSCIPHERPSK}"
     update_config_var $ZBX_AGENT_CONFIG "TLSCipherPSK13" "${ZBX_TLSCIPHERPSK13}"
-    update_config_var $ZBX_AGENT_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}"
+    file_process_from_env $ZBX_AGENT_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}" "${ZBX_TLSKEY}"
     update_config_var $ZBX_AGENT_CONFIG "TLSPSKIdentity" "${ZBX_TLSPSKIDENTITY}"
-    update_config_var $ZBX_AGENT_CONFIG "TLSPSKFile" "${ZBX_TLSPSKFILE}"
+    file_process_from_env $ZBX_AGENT_CONFIG "TLSPSKFile" "${ZBX_TLSPSKFILE}" "${ZBX_TLSPSK}"
 
     update_config_multiple_var $ZBX_AGENT_CONFIG "DenyKey" "${ZBX_DENYKEY}"
     update_config_multiple_var $ZBX_AGENT_CONFIG "AllowKey" "${ZBX_ALLOWKEY}"
diff --git a/Dockerfiles/agent2/README.md b/Dockerfiles/agent2/README.md
index 46cd98235..24a6422ca 100644
--- a/Dockerfiles/agent2/README.md
+++ b/Dockerfiles/agent2/README.md
@@ -147,13 +147,18 @@ ZBX_UNSAFEUSERPARAMETERS=0
 ZBX_TLSCONNECT=unencrypted
 ZBX_TLSACCEPT=unencrypted
 ZBX_TLSCAFILE=
+ZBX_TLSCA=
 ZBX_TLSCRLFILE=
+ZBX_TLSCRL=
 ZBX_TLSSERVERCERTISSUER=
 ZBX_TLSSERVERCERTSUBJECT=
 ZBX_TLSCERTFILE=
+ZBX_TLSCERT=
 ZBX_TLSKEYFILE=
+ZBX_TLSKEY=
 ZBX_TLSPSKIDENTITY=
 ZBX_TLSPSKFILE=
+ZBX_TLSPSK=
 ZBX_DENYKEY=system.run[*] # Available since 5.0.0
 ZBX_ALLOWKEY= # Available since 5.0.0
 ```
@@ -172,7 +177,7 @@ The volume allows include ``*.conf`` files and extend Zabbix agent 2 using ``Use
 
 ### ``/var/lib/zabbix/enc``
 
-The volume is used to store TLS related files. These file names are specified using ``ZBX_TLSCAFILE``, ``ZBX_TLSCRLFILE``, ``ZBX_TLSKEY_FILE`` and ``ZBX_TLSPSKFILE`` variables.
+The volume is used to store TLS related files. These file names are specified using ``ZBX_TLSCAFILE``, ``ZBX_TLSCRLFILE``, ``ZBX_TLSCERTFILE``, ``ZBX_TLSKEYFILE`` and ``ZBX_TLSPSKFILE`` variables. Additionally it is possible to use environment variables ``ZBX_TLSCA``, ``ZBX_TLSCRL``, ``ZBX_TLSCERT``, ``ZBX_TLSKEY`` and ``ZBX_TLSPSK`` with plaintext values.
 
 ### ``/var/lib/zabbix/buffer``
 
diff --git a/Dockerfiles/agent2/alpine/Dockerfile b/Dockerfiles/agent2/alpine/Dockerfile
index a8e14d082..c74c4308c 100644
--- a/Dockerfiles/agent2/alpine/Dockerfile
+++ b/Dockerfiles/agent2/alpine/Dockerfile
@@ -62,6 +62,7 @@ RUN set -eux && \
     mkdir -p /etc/zabbix/zabbix_agentd.d && \
     mkdir -p /var/lib/zabbix && \
     mkdir -p /var/lib/zabbix/enc && \
+    mkdir -p /var/lib/zabbix/enc_internal && \
     mkdir -p /var/lib/zabbix/modules && \
     mkdir -p /var/lib/zabbix/buffer && \
     chown --quiet -R zabbix:root /etc/zabbix/ /var/lib/zabbix/ && \
diff --git a/Dockerfiles/agent2/alpine/docker-entrypoint.sh b/Dockerfiles/agent2/alpine/docker-entrypoint.sh
index ae77445a2..db6b5a301 100755
--- a/Dockerfiles/agent2/alpine/docker-entrypoint.sh
+++ b/Dockerfiles/agent2/alpine/docker-entrypoint.sh
@@ -20,6 +20,8 @@ fi
 ZABBIX_USER_HOME_DIR="/var/lib/zabbix"
 # Configuration files directory
 ZABBIX_ETC_DIR="/etc/zabbix"
+# Internal directory for TLS related files, used when TLS*File specified as plain text values
+ZABBIX_INTERNAL_ENC_DIR="${ZABBIX_USER_HOME_DIR}/enc_internal"
 
 escape_spec_char() {
     local var_value=$1
@@ -112,6 +114,19 @@ update_config_multiple_var() {
     done
 }
 
+file_process_from_env() {
+    local config_path=$1
+    local var_name=$2
+    local file_name=$3
+    local var_value=$4
+
+    if [ ! -z "$var_value" ]; then
+        echo -n "$var_value" > "${ZABBIX_INTERNAL_ENC_DIR}/$var_name"
+        file_name="${ZABBIX_INTERNAL_ENC_DIR}/${var_name}"
+    fi
+    update_config_var $config_path "$var_name" "$file_name"
+}
+
 prepare_zbx_agent_config() {
     echo "** Preparing Zabbix agent configuration file"
     ZBX_AGENT_CONFIG=$ZABBIX_ETC_DIR/zabbix_agent2.conf
@@ -182,14 +197,14 @@ prepare_zbx_agent_config() {
     update_config_var $ZBX_AGENT_CONFIG "UnsafeUserParameters" "${ZBX_UNSAFEUSERPARAMETERS}"
     update_config_var $ZBX_AGENT_CONFIG "TLSConnect" "${ZBX_TLSCONNECT}"
     update_config_var $ZBX_AGENT_CONFIG "TLSAccept" "${ZBX_TLSACCEPT}"
-    update_config_var $ZBX_AGENT_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}"
-    update_config_var $ZBX_AGENT_CONFIG "TLSCRLFile" "${ZBX_TLSCRLFILE}"
+    file_process_from_env $ZBX_AGENT_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}" "${ZBX_TLSCA}"
+    file_process_from_env $ZBX_AGENT_CONFIG "TLSCRLFile" "${ZBX_TLSCRLFILE}" "${ZBX_TLSCRL}"
     update_config_var $ZBX_AGENT_CONFIG "TLSServerCertIssuer" "${ZBX_TLSSERVERCERTISSUER}"
     update_config_var $ZBX_AGENT_CONFIG "TLSServerCertSubject" "${ZBX_TLSSERVERCERTSUBJECT}"
-    update_config_var $ZBX_AGENT_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}"
-    update_config_var $ZBX_AGENT_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}"
+    file_process_from_env $ZBX_AGENT_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}" "${ZBX_TLSCERT}"
+    file_process_from_env $ZBX_AGENT_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}" "${ZBX_TLSKEY}"
     update_config_var $ZBX_AGENT_CONFIG "TLSPSKIdentity" "${ZBX_TLSPSKIDENTITY}"
-    update_config_var $ZBX_AGENT_CONFIG "TLSPSKFile" "${ZBX_TLSPSKFILE}"
+    file_process_from_env $ZBX_AGENT_CONFIG "TLSPSKFile" "${ZBX_TLSPSKFILE}" "${ZBX_TLSPSK}"
 
     update_config_multiple_var $ZBX_AGENT_CONFIG "DenyKey" "${ZBX_DENYKEY}"
     update_config_multiple_var $ZBX_AGENT_CONFIG "AllowKey" "${ZBX_ALLOWKEY}"
diff --git a/Dockerfiles/agent2/centos/Dockerfile b/Dockerfiles/agent2/centos/Dockerfile
index e29a8a0e3..2f12aaccc 100644
--- a/Dockerfiles/agent2/centos/Dockerfile
+++ b/Dockerfiles/agent2/centos/Dockerfile
@@ -67,6 +67,7 @@ RUN --mount=type=tmpfs,target=/var/lib/dnf/ \
     mkdir -p /etc/zabbix/zabbix_agentd.d && \
     mkdir -p /var/lib/zabbix && \
     mkdir -p /var/lib/zabbix/enc && \
+    mkdir -p /var/lib/zabbix/enc_internal && \
     mkdir -p /var/lib/zabbix/modules && \
     mkdir -p /var/lib/zabbix/buffer && \
     chown --quiet -R zabbix:root /etc/zabbix/ /var/lib/zabbix/ && \
diff --git a/Dockerfiles/agent2/centos/docker-entrypoint.sh b/Dockerfiles/agent2/centos/docker-entrypoint.sh
index ae77445a2..db6b5a301 100755
--- a/Dockerfiles/agent2/centos/docker-entrypoint.sh
+++ b/Dockerfiles/agent2/centos/docker-entrypoint.sh
@@ -20,6 +20,8 @@ fi
 ZABBIX_USER_HOME_DIR="/var/lib/zabbix"
 # Configuration files directory
 ZABBIX_ETC_DIR="/etc/zabbix"
+# Internal directory for TLS related files, used when TLS*File specified as plain text values
+ZABBIX_INTERNAL_ENC_DIR="${ZABBIX_USER_HOME_DIR}/enc_internal"
 
 escape_spec_char() {
     local var_value=$1
@@ -112,6 +114,19 @@ update_config_multiple_var() {
     done
 }
 
+file_process_from_env() {
+    local config_path=$1
+    local var_name=$2
+    local file_name=$3
+    local var_value=$4
+
+    if [ ! -z "$var_value" ]; then
+        echo -n "$var_value" > "${ZABBIX_INTERNAL_ENC_DIR}/$var_name"
+        file_name="${ZABBIX_INTERNAL_ENC_DIR}/${var_name}"
+    fi
+    update_config_var $config_path "$var_name" "$file_name"
+}
+
 prepare_zbx_agent_config() {
     echo "** Preparing Zabbix agent configuration file"
     ZBX_AGENT_CONFIG=$ZABBIX_ETC_DIR/zabbix_agent2.conf
@@ -182,14 +197,14 @@ prepare_zbx_agent_config() {
     update_config_var $ZBX_AGENT_CONFIG "UnsafeUserParameters" "${ZBX_UNSAFEUSERPARAMETERS}"
     update_config_var $ZBX_AGENT_CONFIG "TLSConnect" "${ZBX_TLSCONNECT}"
     update_config_var $ZBX_AGENT_CONFIG "TLSAccept" "${ZBX_TLSACCEPT}"
-    update_config_var $ZBX_AGENT_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}"
-    update_config_var $ZBX_AGENT_CONFIG "TLSCRLFile" "${ZBX_TLSCRLFILE}"
+    file_process_from_env $ZBX_AGENT_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}" "${ZBX_TLSCA}"
+    file_process_from_env $ZBX_AGENT_CONFIG "TLSCRLFile" "${ZBX_TLSCRLFILE}" "${ZBX_TLSCRL}"
     update_config_var $ZBX_AGENT_CONFIG "TLSServerCertIssuer" "${ZBX_TLSSERVERCERTISSUER}"
     update_config_var $ZBX_AGENT_CONFIG "TLSServerCertSubject" "${ZBX_TLSSERVERCERTSUBJECT}"
-    update_config_var $ZBX_AGENT_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}"
-    update_config_var $ZBX_AGENT_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}"
+    file_process_from_env $ZBX_AGENT_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}" "${ZBX_TLSCERT}"
+    file_process_from_env $ZBX_AGENT_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}" "${ZBX_TLSKEY}"
     update_config_var $ZBX_AGENT_CONFIG "TLSPSKIdentity" "${ZBX_TLSPSKIDENTITY}"
-    update_config_var $ZBX_AGENT_CONFIG "TLSPSKFile" "${ZBX_TLSPSKFILE}"
+    file_process_from_env $ZBX_AGENT_CONFIG "TLSPSKFile" "${ZBX_TLSPSKFILE}" "${ZBX_TLSPSK}"
 
     update_config_multiple_var $ZBX_AGENT_CONFIG "DenyKey" "${ZBX_DENYKEY}"
     update_config_multiple_var $ZBX_AGENT_CONFIG "AllowKey" "${ZBX_ALLOWKEY}"
diff --git a/Dockerfiles/agent2/ol/Dockerfile b/Dockerfiles/agent2/ol/Dockerfile
index 90c728a66..085bae321 100644
--- a/Dockerfiles/agent2/ol/Dockerfile
+++ b/Dockerfiles/agent2/ol/Dockerfile
@@ -69,6 +69,7 @@ RUN --mount=type=tmpfs,target=/var/lib/dnf/ \
     mkdir -p /etc/zabbix/zabbix_agentd.d && \
     mkdir -p /var/lib/zabbix && \
     mkdir -p /var/lib/zabbix/enc && \
+    mkdir -p /var/lib/zabbix/enc_internal && \
     mkdir -p /var/lib/zabbix/modules && \
     mkdir -p /var/lib/zabbix/buffer && \
     chown --quiet -R zabbix:root /etc/zabbix/ /var/lib/zabbix/ && \
diff --git a/Dockerfiles/agent2/ol/docker-entrypoint.sh b/Dockerfiles/agent2/ol/docker-entrypoint.sh
index ae77445a2..db6b5a301 100755
--- a/Dockerfiles/agent2/ol/docker-entrypoint.sh
+++ b/Dockerfiles/agent2/ol/docker-entrypoint.sh
@@ -20,6 +20,8 @@ fi
 ZABBIX_USER_HOME_DIR="/var/lib/zabbix"
 # Configuration files directory
 ZABBIX_ETC_DIR="/etc/zabbix"
+# Internal directory for TLS related files, used when TLS*File specified as plain text values
+ZABBIX_INTERNAL_ENC_DIR="${ZABBIX_USER_HOME_DIR}/enc_internal"
 
 escape_spec_char() {
     local var_value=$1
@@ -112,6 +114,19 @@ update_config_multiple_var() {
     done
 }
 
+file_process_from_env() {
+    local config_path=$1
+    local var_name=$2
+    local file_name=$3
+    local var_value=$4
+
+    if [ ! -z "$var_value" ]; then
+        echo -n "$var_value" > "${ZABBIX_INTERNAL_ENC_DIR}/$var_name"
+        file_name="${ZABBIX_INTERNAL_ENC_DIR}/${var_name}"
+    fi
+    update_config_var $config_path "$var_name" "$file_name"
+}
+
 prepare_zbx_agent_config() {
     echo "** Preparing Zabbix agent configuration file"
     ZBX_AGENT_CONFIG=$ZABBIX_ETC_DIR/zabbix_agent2.conf
@@ -182,14 +197,14 @@ prepare_zbx_agent_config() {
     update_config_var $ZBX_AGENT_CONFIG "UnsafeUserParameters" "${ZBX_UNSAFEUSERPARAMETERS}"
     update_config_var $ZBX_AGENT_CONFIG "TLSConnect" "${ZBX_TLSCONNECT}"
     update_config_var $ZBX_AGENT_CONFIG "TLSAccept" "${ZBX_TLSACCEPT}"
-    update_config_var $ZBX_AGENT_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}"
-    update_config_var $ZBX_AGENT_CONFIG "TLSCRLFile" "${ZBX_TLSCRLFILE}"
+    file_process_from_env $ZBX_AGENT_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}" "${ZBX_TLSCA}"
+    file_process_from_env $ZBX_AGENT_CONFIG "TLSCRLFile" "${ZBX_TLSCRLFILE}" "${ZBX_TLSCRL}"
     update_config_var $ZBX_AGENT_CONFIG "TLSServerCertIssuer" "${ZBX_TLSSERVERCERTISSUER}"
     update_config_var $ZBX_AGENT_CONFIG "TLSServerCertSubject" "${ZBX_TLSSERVERCERTSUBJECT}"
-    update_config_var $ZBX_AGENT_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}"
-    update_config_var $ZBX_AGENT_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}"
+    file_process_from_env $ZBX_AGENT_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}" "${ZBX_TLSCERT}"
+    file_process_from_env $ZBX_AGENT_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}" "${ZBX_TLSKEY}"
     update_config_var $ZBX_AGENT_CONFIG "TLSPSKIdentity" "${ZBX_TLSPSKIDENTITY}"
-    update_config_var $ZBX_AGENT_CONFIG "TLSPSKFile" "${ZBX_TLSPSKFILE}"
+    file_process_from_env $ZBX_AGENT_CONFIG "TLSPSKFile" "${ZBX_TLSPSKFILE}" "${ZBX_TLSPSK}"
 
     update_config_multiple_var $ZBX_AGENT_CONFIG "DenyKey" "${ZBX_DENYKEY}"
     update_config_multiple_var $ZBX_AGENT_CONFIG "AllowKey" "${ZBX_ALLOWKEY}"
diff --git a/Dockerfiles/agent2/rhel/Dockerfile b/Dockerfiles/agent2/rhel/Dockerfile
index efe2ddc36..226fde9ea 100644
--- a/Dockerfiles/agent2/rhel/Dockerfile
+++ b/Dockerfiles/agent2/rhel/Dockerfile
@@ -96,6 +96,7 @@ RUN --mount=type=tmpfs,target=/var/lib/dnf/ \
     mkdir -p /etc/zabbix/zabbix_agentd.d && \
     mkdir -p /var/lib/zabbix && \
     mkdir -p /var/lib/zabbix/enc && \
+    mkdir -p /var/lib/zabbix/enc_internal && \
     mkdir -p /var/lib/zabbix/modules && \
     mkdir -p /var/lib/zabbix/buffer && \
     chown --quiet -R zabbix:root /etc/zabbix/ /var/lib/zabbix/ && \
diff --git a/Dockerfiles/agent2/rhel/docker-entrypoint.sh b/Dockerfiles/agent2/rhel/docker-entrypoint.sh
index ae77445a2..db6b5a301 100755
--- a/Dockerfiles/agent2/rhel/docker-entrypoint.sh
+++ b/Dockerfiles/agent2/rhel/docker-entrypoint.sh
@@ -20,6 +20,8 @@ fi
 ZABBIX_USER_HOME_DIR="/var/lib/zabbix"
 # Configuration files directory
 ZABBIX_ETC_DIR="/etc/zabbix"
+# Internal directory for TLS related files, used when TLS*File specified as plain text values
+ZABBIX_INTERNAL_ENC_DIR="${ZABBIX_USER_HOME_DIR}/enc_internal"
 
 escape_spec_char() {
     local var_value=$1
@@ -112,6 +114,19 @@ update_config_multiple_var() {
     done
 }
 
+file_process_from_env() {
+    local config_path=$1
+    local var_name=$2
+    local file_name=$3
+    local var_value=$4
+
+    if [ ! -z "$var_value" ]; then
+        echo -n "$var_value" > "${ZABBIX_INTERNAL_ENC_DIR}/$var_name"
+        file_name="${ZABBIX_INTERNAL_ENC_DIR}/${var_name}"
+    fi
+    update_config_var $config_path "$var_name" "$file_name"
+}
+
 prepare_zbx_agent_config() {
     echo "** Preparing Zabbix agent configuration file"
     ZBX_AGENT_CONFIG=$ZABBIX_ETC_DIR/zabbix_agent2.conf
@@ -182,14 +197,14 @@ prepare_zbx_agent_config() {
     update_config_var $ZBX_AGENT_CONFIG "UnsafeUserParameters" "${ZBX_UNSAFEUSERPARAMETERS}"
     update_config_var $ZBX_AGENT_CONFIG "TLSConnect" "${ZBX_TLSCONNECT}"
     update_config_var $ZBX_AGENT_CONFIG "TLSAccept" "${ZBX_TLSACCEPT}"
-    update_config_var $ZBX_AGENT_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}"
-    update_config_var $ZBX_AGENT_CONFIG "TLSCRLFile" "${ZBX_TLSCRLFILE}"
+    file_process_from_env $ZBX_AGENT_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}" "${ZBX_TLSCA}"
+    file_process_from_env $ZBX_AGENT_CONFIG "TLSCRLFile" "${ZBX_TLSCRLFILE}" "${ZBX_TLSCRL}"
     update_config_var $ZBX_AGENT_CONFIG "TLSServerCertIssuer" "${ZBX_TLSSERVERCERTISSUER}"
     update_config_var $ZBX_AGENT_CONFIG "TLSServerCertSubject" "${ZBX_TLSSERVERCERTSUBJECT}"
-    update_config_var $ZBX_AGENT_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}"
-    update_config_var $ZBX_AGENT_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}"
+    file_process_from_env $ZBX_AGENT_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}" "${ZBX_TLSCERT}"
+    file_process_from_env $ZBX_AGENT_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}" "${ZBX_TLSKEY}"
     update_config_var $ZBX_AGENT_CONFIG "TLSPSKIdentity" "${ZBX_TLSPSKIDENTITY}"
-    update_config_var $ZBX_AGENT_CONFIG "TLSPSKFile" "${ZBX_TLSPSKFILE}"
+    file_process_from_env $ZBX_AGENT_CONFIG "TLSPSKFile" "${ZBX_TLSPSKFILE}" "${ZBX_TLSPSK}"
 
     update_config_multiple_var $ZBX_AGENT_CONFIG "DenyKey" "${ZBX_DENYKEY}"
     update_config_multiple_var $ZBX_AGENT_CONFIG "AllowKey" "${ZBX_ALLOWKEY}"
diff --git a/Dockerfiles/agent2/ubuntu/Dockerfile b/Dockerfiles/agent2/ubuntu/Dockerfile
index fba22cb3c..01a16b20c 100644
--- a/Dockerfiles/agent2/ubuntu/Dockerfile
+++ b/Dockerfiles/agent2/ubuntu/Dockerfile
@@ -62,6 +62,7 @@ RUN --mount=type=cache,target=/var/lib/apt/,sharing=locked \
     mkdir -p /etc/zabbix/zabbix_agentd.d && \
     mkdir -p /var/lib/zabbix && \
     mkdir -p /var/lib/zabbix/enc && \
+    mkdir -p /var/lib/zabbix/enc_internal && \
     mkdir -p /var/lib/zabbix/modules && \
     mkdir -p /var/lib/zabbix/buffer && \
     chown --quiet -R zabbix:root /etc/zabbix/ /var/lib/zabbix/ && \
diff --git a/Dockerfiles/agent2/ubuntu/docker-entrypoint.sh b/Dockerfiles/agent2/ubuntu/docker-entrypoint.sh
index ae77445a2..db6b5a301 100755
--- a/Dockerfiles/agent2/ubuntu/docker-entrypoint.sh
+++ b/Dockerfiles/agent2/ubuntu/docker-entrypoint.sh
@@ -20,6 +20,8 @@ fi
 ZABBIX_USER_HOME_DIR="/var/lib/zabbix"
 # Configuration files directory
 ZABBIX_ETC_DIR="/etc/zabbix"
+# Internal directory for TLS related files, used when TLS*File specified as plain text values
+ZABBIX_INTERNAL_ENC_DIR="${ZABBIX_USER_HOME_DIR}/enc_internal"
 
 escape_spec_char() {
     local var_value=$1
@@ -112,6 +114,19 @@ update_config_multiple_var() {
     done
 }
 
+file_process_from_env() {
+    local config_path=$1
+    local var_name=$2
+    local file_name=$3
+    local var_value=$4
+
+    if [ ! -z "$var_value" ]; then
+        echo -n "$var_value" > "${ZABBIX_INTERNAL_ENC_DIR}/$var_name"
+        file_name="${ZABBIX_INTERNAL_ENC_DIR}/${var_name}"
+    fi
+    update_config_var $config_path "$var_name" "$file_name"
+}
+
 prepare_zbx_agent_config() {
     echo "** Preparing Zabbix agent configuration file"
     ZBX_AGENT_CONFIG=$ZABBIX_ETC_DIR/zabbix_agent2.conf
@@ -182,14 +197,14 @@ prepare_zbx_agent_config() {
     update_config_var $ZBX_AGENT_CONFIG "UnsafeUserParameters" "${ZBX_UNSAFEUSERPARAMETERS}"
     update_config_var $ZBX_AGENT_CONFIG "TLSConnect" "${ZBX_TLSCONNECT}"
     update_config_var $ZBX_AGENT_CONFIG "TLSAccept" "${ZBX_TLSACCEPT}"
-    update_config_var $ZBX_AGENT_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}"
-    update_config_var $ZBX_AGENT_CONFIG "TLSCRLFile" "${ZBX_TLSCRLFILE}"
+    file_process_from_env $ZBX_AGENT_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}" "${ZBX_TLSCA}"
+    file_process_from_env $ZBX_AGENT_CONFIG "TLSCRLFile" "${ZBX_TLSCRLFILE}" "${ZBX_TLSCRL}"
     update_config_var $ZBX_AGENT_CONFIG "TLSServerCertIssuer" "${ZBX_TLSSERVERCERTISSUER}"
     update_config_var $ZBX_AGENT_CONFIG "TLSServerCertSubject" "${ZBX_TLSSERVERCERTSUBJECT}"
-    update_config_var $ZBX_AGENT_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}"
-    update_config_var $ZBX_AGENT_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}"
+    file_process_from_env $ZBX_AGENT_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}" "${ZBX_TLSCERT}"
+    file_process_from_env $ZBX_AGENT_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}" "${ZBX_TLSKEY}"
     update_config_var $ZBX_AGENT_CONFIG "TLSPSKIdentity" "${ZBX_TLSPSKIDENTITY}"
-    update_config_var $ZBX_AGENT_CONFIG "TLSPSKFile" "${ZBX_TLSPSKFILE}"
+    file_process_from_env $ZBX_AGENT_CONFIG "TLSPSKFile" "${ZBX_TLSPSKFILE}" "${ZBX_TLSPSK}"
 
     update_config_multiple_var $ZBX_AGENT_CONFIG "DenyKey" "${ZBX_DENYKEY}"
     update_config_multiple_var $ZBX_AGENT_CONFIG "AllowKey" "${ZBX_ALLOWKEY}"
diff --git a/Dockerfiles/proxy-mysql/README.md b/Dockerfiles/proxy-mysql/README.md
index 2cf9da9cf..b259e0b62 100644
--- a/Dockerfiles/proxy-mysql/README.md
+++ b/Dockerfiles/proxy-mysql/README.md
@@ -220,13 +220,18 @@ ZBX_LOGSLOWQUERIES=3000
 ZBX_TLSCONNECT=unencrypted
 ZBX_TLSACCEPT=unencrypted
 ZBX_TLSCAFILE=
+ZBX_TLSCA=
 ZBX_TLSCRLFILE=
+ZBX_TLSCRL=
 ZBX_TLSSERVERCERTISSUER=
 ZBX_TLSSERVERCERTSUBJECT=
 ZBX_TLSCERTFILE=
+ZBX_TLSCERT=
 ZBX_TLSKEYFILE=
+ZBX_TLSKEY=
 ZBX_TLSPSKIDENTITY=
 ZBX_TLSPSKFILE=
+ZBX_TLSPSK=
 ZBX_TLSCIPHERALL= # Available since 4.4.7
 ZBX_TLSCIPHERALL13= # Available since 4.4.7
 ZBX_TLSCIPHERCERT= # Available since 4.4.7
@@ -253,7 +258,7 @@ The volume allows load additional modules and extend Zabbix proxy using ``LoadMo
 
 ### ``/var/lib/zabbix/enc``
 
-The volume is used to store TLS related files. These file names are specified using ``ZBX_TLSCAFILE``, ``ZBX_TLSCRLFILE``, ``ZBX_TLSKEY_FILE`` and ``ZBX_TLSPSKFILE`` variables.
+The volume is used to store TLS related files. These file names are specified using ``ZBX_TLSCAFILE``, ``ZBX_TLSCRLFILE``, ``ZBX_TLSCERTFILE``, ``ZBX_TLSKEYFILE`` and ``ZBX_TLSPSKFILE`` variables. Additionally it is possible to use environment variables ``ZBX_TLSCA``, ``ZBX_TLSCRL``, ``ZBX_TLSCERT``, ``ZBX_TLSKEY`` and ``ZBX_TLSPSK`` with plaintext values.
 
 ### ``/var/lib/zabbix/ssh_keys``
 
diff --git a/Dockerfiles/proxy-mysql/alpine/Dockerfile b/Dockerfiles/proxy-mysql/alpine/Dockerfile
index 93df083ab..559a7aa6d 100644
--- a/Dockerfiles/proxy-mysql/alpine/Dockerfile
+++ b/Dockerfiles/proxy-mysql/alpine/Dockerfile
@@ -74,6 +74,7 @@ RUN set -eux && \
     mkdir -p /etc/zabbix && \
     mkdir -p /var/lib/zabbix && \
     mkdir -p /var/lib/zabbix/enc && \
+    mkdir -p /var/lib/zabbix/enc_internal && \
     mkdir -p /usr/lib/zabbix/externalscripts && \
     mkdir -p /var/lib/zabbix/mibs && \
     mkdir -p /var/lib/zabbix/modules && \
diff --git a/Dockerfiles/proxy-mysql/alpine/docker-entrypoint.sh b/Dockerfiles/proxy-mysql/alpine/docker-entrypoint.sh
index ccda51130..fa4ac0195 100755
--- a/Dockerfiles/proxy-mysql/alpine/docker-entrypoint.sh
+++ b/Dockerfiles/proxy-mysql/alpine/docker-entrypoint.sh
@@ -19,6 +19,8 @@ fi
 ZABBIX_USER_HOME_DIR="/var/lib/zabbix"
 # Configuration files directory
 ZABBIX_ETC_DIR="/etc/zabbix"
+# Internal directory for TLS related files, used when TLS*File specified as plain text values
+ZABBIX_INTERNAL_ENC_DIR="${ZABBIX_USER_HOME_DIR}/enc_internal"
 
 : ${DB_CHARACTER_SET:="utf8"}
 : ${DB_CHARACTER_COLLATE:="utf8_bin"}
@@ -142,6 +144,19 @@ update_config_multiple_var() {
     done
 }
 
+file_process_from_env() {
+    local config_path=$1
+    local var_name=$2
+    local file_name=$3
+    local var_value=$4
+
+    if [ ! -z "$var_value" ]; then
+        echo -n "$var_value" > "${ZABBIX_INTERNAL_ENC_DIR}/$var_name"
+        file_name="${ZABBIX_INTERNAL_ENC_DIR}/${var_name}"
+    fi
+    update_config_var $config_path "$var_name" "$file_name"
+}
+
 # Check prerequisites for MySQL database
 check_variables_mysql() {
     if [ ! -n "${DB_SERVER_SOCKET}" ]; then
@@ -459,23 +474,23 @@ update_zbx_config() {
 
     update_config_var $ZBX_CONFIG "TLSConnect" "${ZBX_TLSCONNECT}"
     update_config_var $ZBX_CONFIG "TLSAccept" "${ZBX_TLSACCEPT}"
-    update_config_var $ZBX_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}"
-    update_config_var $ZBX_CONFIG "TLSCRLFile" "${ZBX_TLSCRLFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}" "${ZBX_TLSCA}"
+    file_process_from_env $ZBX_CONFIG "TLSCRLFile" "${ZBX_TLSCRLFILE}" "${ZBX_TLSCRL}"
 
     update_config_var $ZBX_CONFIG "TLSServerCertIssuer" "${ZBX_TLSSERVERCERTISSUER}"
     update_config_var $ZBX_CONFIG "TLSServerCertSubject" "${ZBX_TLSSERVERCERTSUBJECT}"
 
-    update_config_var $ZBX_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}" "${ZBX_TLSCERT}"
     update_config_var $ZBX_CONFIG "TLSCipherAll" "${ZBX_TLSCIPHERALL}"
     update_config_var $ZBX_CONFIG "TLSCipherAll13" "${ZBX_TLSCIPHERALL13}"
     update_config_var $ZBX_CONFIG "TLSCipherCert" "${ZBX_TLSCIPHERCERT}"
     update_config_var $ZBX_CONFIG "TLSCipherCert13" "${ZBX_TLSCIPHERCERT13}"
     update_config_var $ZBX_CONFIG "TLSCipherPSK" "${ZBX_TLSCIPHERPSK}"
     update_config_var $ZBX_CONFIG "TLSCipherPSK13" "${ZBX_TLSCIPHERPSK13}"
-    update_config_var $ZBX_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}" "${ZBX_TLSKEY}"
 
     update_config_var $ZBX_CONFIG "TLSPSKIdentity" "${ZBX_TLSPSKIDENTITY}"
-    update_config_var $ZBX_CONFIG "TLSPSKFile" "${ZBX_TLSPSKFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSPSKFile" "${ZBX_TLSPSKFILE}" "${ZBX_TLSPSK}"
 
     if [ "$(id -u)" != '0' ]; then
         update_config_var $ZBX_CONFIG "User" "$(whoami)"
diff --git a/Dockerfiles/proxy-mysql/centos/Dockerfile b/Dockerfiles/proxy-mysql/centos/Dockerfile
index 86056660b..5d441b20b 100644
--- a/Dockerfiles/proxy-mysql/centos/Dockerfile
+++ b/Dockerfiles/proxy-mysql/centos/Dockerfile
@@ -80,6 +80,7 @@ RUN --mount=type=tmpfs,target=/var/lib/dnf/ \
     mkdir -p /etc/zabbix && \
     mkdir -p /var/lib/zabbix && \
     mkdir -p /var/lib/zabbix/enc && \
+    mkdir -p /var/lib/zabbix/enc_internal && \
     mkdir -p /usr/lib/zabbix/externalscripts && \
     mkdir -p /var/lib/zabbix/mibs && \
     mkdir -p /var/lib/zabbix/modules && \
diff --git a/Dockerfiles/proxy-mysql/centos/docker-entrypoint.sh b/Dockerfiles/proxy-mysql/centos/docker-entrypoint.sh
index 13c559488..112dc34b0 100755
--- a/Dockerfiles/proxy-mysql/centos/docker-entrypoint.sh
+++ b/Dockerfiles/proxy-mysql/centos/docker-entrypoint.sh
@@ -19,6 +19,8 @@ fi
 ZABBIX_USER_HOME_DIR="/var/lib/zabbix"
 # Configuration files directory
 ZABBIX_ETC_DIR="/etc/zabbix"
+# Internal directory for TLS related files, used when TLS*File specified as plain text values
+ZABBIX_INTERNAL_ENC_DIR="${ZABBIX_USER_HOME_DIR}/enc_internal"
 
 : ${DB_CHARACTER_SET:="utf8"}
 : ${DB_CHARACTER_COLLATE:="utf8_bin"}
@@ -142,6 +144,19 @@ update_config_multiple_var() {
     done
 }
 
+file_process_from_env() {
+    local config_path=$1
+    local var_name=$2
+    local file_name=$3
+    local var_value=$4
+
+    if [ ! -z "$var_value" ]; then
+        echo -n "$var_value" > "${ZABBIX_INTERNAL_ENC_DIR}/$var_name"
+        file_name="${ZABBIX_INTERNAL_ENC_DIR}/${var_name}"
+    fi
+    update_config_var $config_path "$var_name" "$file_name"
+}
+
 # Check prerequisites for MySQL database
 check_variables_mysql() {
     if [ ! -n "${DB_SERVER_SOCKET}" ]; then
@@ -456,23 +471,23 @@ update_zbx_config() {
 
     update_config_var $ZBX_CONFIG "TLSConnect" "${ZBX_TLSCONNECT}"
     update_config_var $ZBX_CONFIG "TLSAccept" "${ZBX_TLSACCEPT}"
-    update_config_var $ZBX_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}"
-    update_config_var $ZBX_CONFIG "TLSCRLFile" "${ZBX_TLSCRLFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}" "${ZBX_TLSCA}"
+    file_process_from_env $ZBX_CONFIG "TLSCRLFile" "${ZBX_TLSCRLFILE}" "${ZBX_TLSCRL}"
 
     update_config_var $ZBX_CONFIG "TLSServerCertIssuer" "${ZBX_TLSSERVERCERTISSUER}"
     update_config_var $ZBX_CONFIG "TLSServerCertSubject" "${ZBX_TLSSERVERCERTSUBJECT}"
 
-    update_config_var $ZBX_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}" "${ZBX_TLSCERT}"
     update_config_var $ZBX_CONFIG "TLSCipherAll" "${ZBX_TLSCIPHERALL}"
     update_config_var $ZBX_CONFIG "TLSCipherAll13" "${ZBX_TLSCIPHERALL13}"
     update_config_var $ZBX_CONFIG "TLSCipherCert" "${ZBX_TLSCIPHERCERT}"
     update_config_var $ZBX_CONFIG "TLSCipherCert13" "${ZBX_TLSCIPHERCERT13}"
     update_config_var $ZBX_CONFIG "TLSCipherPSK" "${ZBX_TLSCIPHERPSK}"
     update_config_var $ZBX_CONFIG "TLSCipherPSK13" "${ZBX_TLSCIPHERPSK13}"
-    update_config_var $ZBX_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}" "${ZBX_TLSKEY}"
 
     update_config_var $ZBX_CONFIG "TLSPSKIdentity" "${ZBX_TLSPSKIDENTITY}"
-    update_config_var $ZBX_CONFIG "TLSPSKFile" "${ZBX_TLSPSKFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSPSKFile" "${ZBX_TLSPSKFILE}" "${ZBX_TLSPSK}"
 
     if [ "$(id -u)" != '0' ]; then
         update_config_var $ZBX_CONFIG "User" "$(whoami)"
diff --git a/Dockerfiles/proxy-mysql/ol/Dockerfile b/Dockerfiles/proxy-mysql/ol/Dockerfile
index eb3743f7f..e05c3e570 100644
--- a/Dockerfiles/proxy-mysql/ol/Dockerfile
+++ b/Dockerfiles/proxy-mysql/ol/Dockerfile
@@ -81,6 +81,7 @@ RUN --mount=type=tmpfs,target=/var/lib/dnf/ \
     mkdir -p /etc/zabbix && \
     mkdir -p /var/lib/zabbix && \
     mkdir -p /var/lib/zabbix/enc && \
+    mkdir -p /var/lib/zabbix/enc_internal && \
     mkdir -p /usr/lib/zabbix/externalscripts && \
     mkdir -p /var/lib/zabbix/mibs && \
     mkdir -p /var/lib/zabbix/modules && \
diff --git a/Dockerfiles/proxy-mysql/ol/docker-entrypoint.sh b/Dockerfiles/proxy-mysql/ol/docker-entrypoint.sh
index 13c559488..112dc34b0 100755
--- a/Dockerfiles/proxy-mysql/ol/docker-entrypoint.sh
+++ b/Dockerfiles/proxy-mysql/ol/docker-entrypoint.sh
@@ -19,6 +19,8 @@ fi
 ZABBIX_USER_HOME_DIR="/var/lib/zabbix"
 # Configuration files directory
 ZABBIX_ETC_DIR="/etc/zabbix"
+# Internal directory for TLS related files, used when TLS*File specified as plain text values
+ZABBIX_INTERNAL_ENC_DIR="${ZABBIX_USER_HOME_DIR}/enc_internal"
 
 : ${DB_CHARACTER_SET:="utf8"}
 : ${DB_CHARACTER_COLLATE:="utf8_bin"}
@@ -142,6 +144,19 @@ update_config_multiple_var() {
     done
 }
 
+file_process_from_env() {
+    local config_path=$1
+    local var_name=$2
+    local file_name=$3
+    local var_value=$4
+
+    if [ ! -z "$var_value" ]; then
+        echo -n "$var_value" > "${ZABBIX_INTERNAL_ENC_DIR}/$var_name"
+        file_name="${ZABBIX_INTERNAL_ENC_DIR}/${var_name}"
+    fi
+    update_config_var $config_path "$var_name" "$file_name"
+}
+
 # Check prerequisites for MySQL database
 check_variables_mysql() {
     if [ ! -n "${DB_SERVER_SOCKET}" ]; then
@@ -456,23 +471,23 @@ update_zbx_config() {
 
     update_config_var $ZBX_CONFIG "TLSConnect" "${ZBX_TLSCONNECT}"
     update_config_var $ZBX_CONFIG "TLSAccept" "${ZBX_TLSACCEPT}"
-    update_config_var $ZBX_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}"
-    update_config_var $ZBX_CONFIG "TLSCRLFile" "${ZBX_TLSCRLFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}" "${ZBX_TLSCA}"
+    file_process_from_env $ZBX_CONFIG "TLSCRLFile" "${ZBX_TLSCRLFILE}" "${ZBX_TLSCRL}"
 
     update_config_var $ZBX_CONFIG "TLSServerCertIssuer" "${ZBX_TLSSERVERCERTISSUER}"
     update_config_var $ZBX_CONFIG "TLSServerCertSubject" "${ZBX_TLSSERVERCERTSUBJECT}"
 
-    update_config_var $ZBX_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}" "${ZBX_TLSCERT}"
     update_config_var $ZBX_CONFIG "TLSCipherAll" "${ZBX_TLSCIPHERALL}"
     update_config_var $ZBX_CONFIG "TLSCipherAll13" "${ZBX_TLSCIPHERALL13}"
     update_config_var $ZBX_CONFIG "TLSCipherCert" "${ZBX_TLSCIPHERCERT}"
     update_config_var $ZBX_CONFIG "TLSCipherCert13" "${ZBX_TLSCIPHERCERT13}"
     update_config_var $ZBX_CONFIG "TLSCipherPSK" "${ZBX_TLSCIPHERPSK}"
     update_config_var $ZBX_CONFIG "TLSCipherPSK13" "${ZBX_TLSCIPHERPSK13}"
-    update_config_var $ZBX_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}" "${ZBX_TLSKEY}"
 
     update_config_var $ZBX_CONFIG "TLSPSKIdentity" "${ZBX_TLSPSKIDENTITY}"
-    update_config_var $ZBX_CONFIG "TLSPSKFile" "${ZBX_TLSPSKFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSPSKFile" "${ZBX_TLSPSKFILE}" "${ZBX_TLSPSK}"
 
     if [ "$(id -u)" != '0' ]; then
         update_config_var $ZBX_CONFIG "User" "$(whoami)"
diff --git a/Dockerfiles/proxy-mysql/rhel/Dockerfile b/Dockerfiles/proxy-mysql/rhel/Dockerfile
index b31067635..1406dc19a 100644
--- a/Dockerfiles/proxy-mysql/rhel/Dockerfile
+++ b/Dockerfiles/proxy-mysql/rhel/Dockerfile
@@ -112,6 +112,7 @@ RUN --mount=type=tmpfs,target=/var/lib/dnf/ \
     mkdir -p /etc/zabbix && \
     mkdir -p /var/lib/zabbix && \
     mkdir -p /var/lib/zabbix/enc && \
+    mkdir -p /var/lib/zabbix/enc_internal && \
     mkdir -p /usr/lib/zabbix/externalscripts && \
     mkdir -p /var/lib/zabbix/mibs && \
     mkdir -p /var/lib/zabbix/modules && \
diff --git a/Dockerfiles/proxy-mysql/rhel/docker-entrypoint.sh b/Dockerfiles/proxy-mysql/rhel/docker-entrypoint.sh
index 13c559488..112dc34b0 100755
--- a/Dockerfiles/proxy-mysql/rhel/docker-entrypoint.sh
+++ b/Dockerfiles/proxy-mysql/rhel/docker-entrypoint.sh
@@ -19,6 +19,8 @@ fi
 ZABBIX_USER_HOME_DIR="/var/lib/zabbix"
 # Configuration files directory
 ZABBIX_ETC_DIR="/etc/zabbix"
+# Internal directory for TLS related files, used when TLS*File specified as plain text values
+ZABBIX_INTERNAL_ENC_DIR="${ZABBIX_USER_HOME_DIR}/enc_internal"
 
 : ${DB_CHARACTER_SET:="utf8"}
 : ${DB_CHARACTER_COLLATE:="utf8_bin"}
@@ -142,6 +144,19 @@ update_config_multiple_var() {
     done
 }
 
+file_process_from_env() {
+    local config_path=$1
+    local var_name=$2
+    local file_name=$3
+    local var_value=$4
+
+    if [ ! -z "$var_value" ]; then
+        echo -n "$var_value" > "${ZABBIX_INTERNAL_ENC_DIR}/$var_name"
+        file_name="${ZABBIX_INTERNAL_ENC_DIR}/${var_name}"
+    fi
+    update_config_var $config_path "$var_name" "$file_name"
+}
+
 # Check prerequisites for MySQL database
 check_variables_mysql() {
     if [ ! -n "${DB_SERVER_SOCKET}" ]; then
@@ -456,23 +471,23 @@ update_zbx_config() {
 
     update_config_var $ZBX_CONFIG "TLSConnect" "${ZBX_TLSCONNECT}"
     update_config_var $ZBX_CONFIG "TLSAccept" "${ZBX_TLSACCEPT}"
-    update_config_var $ZBX_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}"
-    update_config_var $ZBX_CONFIG "TLSCRLFile" "${ZBX_TLSCRLFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}" "${ZBX_TLSCA}"
+    file_process_from_env $ZBX_CONFIG "TLSCRLFile" "${ZBX_TLSCRLFILE}" "${ZBX_TLSCRL}"
 
     update_config_var $ZBX_CONFIG "TLSServerCertIssuer" "${ZBX_TLSSERVERCERTISSUER}"
     update_config_var $ZBX_CONFIG "TLSServerCertSubject" "${ZBX_TLSSERVERCERTSUBJECT}"
 
-    update_config_var $ZBX_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}" "${ZBX_TLSCERT}"
     update_config_var $ZBX_CONFIG "TLSCipherAll" "${ZBX_TLSCIPHERALL}"
     update_config_var $ZBX_CONFIG "TLSCipherAll13" "${ZBX_TLSCIPHERALL13}"
     update_config_var $ZBX_CONFIG "TLSCipherCert" "${ZBX_TLSCIPHERCERT}"
     update_config_var $ZBX_CONFIG "TLSCipherCert13" "${ZBX_TLSCIPHERCERT13}"
     update_config_var $ZBX_CONFIG "TLSCipherPSK" "${ZBX_TLSCIPHERPSK}"
     update_config_var $ZBX_CONFIG "TLSCipherPSK13" "${ZBX_TLSCIPHERPSK13}"
-    update_config_var $ZBX_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}" "${ZBX_TLSKEY}"
 
     update_config_var $ZBX_CONFIG "TLSPSKIdentity" "${ZBX_TLSPSKIDENTITY}"
-    update_config_var $ZBX_CONFIG "TLSPSKFile" "${ZBX_TLSPSKFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSPSKFile" "${ZBX_TLSPSKFILE}" "${ZBX_TLSPSK}"
 
     if [ "$(id -u)" != '0' ]; then
         update_config_var $ZBX_CONFIG "User" "$(whoami)"
diff --git a/Dockerfiles/proxy-mysql/ubuntu/Dockerfile b/Dockerfiles/proxy-mysql/ubuntu/Dockerfile
index 941e5c4a3..3432f186c 100644
--- a/Dockerfiles/proxy-mysql/ubuntu/Dockerfile
+++ b/Dockerfiles/proxy-mysql/ubuntu/Dockerfile
@@ -77,6 +77,7 @@ RUN --mount=type=cache,target=/var/lib/apt/,sharing=locked \
     mkdir -p /etc/zabbix && \
     mkdir -p /var/lib/zabbix && \
     mkdir -p /var/lib/zabbix/enc && \
+    mkdir -p /var/lib/zabbix/enc_internal && \
     mkdir -p /usr/lib/zabbix/externalscripts && \
     mkdir -p /var/lib/zabbix/mibs && \
     mkdir -p /var/lib/zabbix/modules && \
diff --git a/Dockerfiles/proxy-mysql/ubuntu/docker-entrypoint.sh b/Dockerfiles/proxy-mysql/ubuntu/docker-entrypoint.sh
index 3e3f36998..79518a878 100755
--- a/Dockerfiles/proxy-mysql/ubuntu/docker-entrypoint.sh
+++ b/Dockerfiles/proxy-mysql/ubuntu/docker-entrypoint.sh
@@ -19,6 +19,8 @@ fi
 ZABBIX_USER_HOME_DIR="/var/lib/zabbix"
 # Configuration files directory
 ZABBIX_ETC_DIR="/etc/zabbix"
+# Internal directory for TLS related files, used when TLS*File specified as plain text values
+ZABBIX_INTERNAL_ENC_DIR="${ZABBIX_USER_HOME_DIR}/enc_internal"
 
 : ${DB_CHARACTER_SET:="utf8"}
 : ${DB_CHARACTER_COLLATE:="utf8_bin"}
@@ -142,6 +144,19 @@ update_config_multiple_var() {
     done
 }
 
+file_process_from_env() {
+    local config_path=$1
+    local var_name=$2
+    local file_name=$3
+    local var_value=$4
+
+    if [ ! -z "$var_value" ]; then
+        echo -n "$var_value" > "${ZABBIX_INTERNAL_ENC_DIR}/$var_name"
+        file_name="${ZABBIX_INTERNAL_ENC_DIR}/${var_name}"
+    fi
+    update_config_var $config_path "$var_name" "$file_name"
+}
+
 # Check prerequisites for MySQL database
 check_variables_mysql() {
     if [ ! -n "${DB_SERVER_SOCKET}" ]; then
@@ -456,23 +471,23 @@ update_zbx_config() {
 
     update_config_var $ZBX_CONFIG "TLSConnect" "${ZBX_TLSCONNECT}"
     update_config_var $ZBX_CONFIG "TLSAccept" "${ZBX_TLSACCEPT}"
-    update_config_var $ZBX_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}"
-    update_config_var $ZBX_CONFIG "TLSCRLFile" "${ZBX_TLSCRLFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}" "${ZBX_TLSCA}"
+    file_process_from_env $ZBX_CONFIG "TLSCRLFile" "${ZBX_TLSCRLFILE}" "${ZBX_TLSCRL}"
 
     update_config_var $ZBX_CONFIG "TLSServerCertIssuer" "${ZBX_TLSSERVERCERTISSUER}"
     update_config_var $ZBX_CONFIG "TLSServerCertSubject" "${ZBX_TLSSERVERCERTSUBJECT}"
 
-    update_config_var $ZBX_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}" "${ZBX_TLSCERT}"
     update_config_var $ZBX_CONFIG "TLSCipherAll" "${ZBX_TLSCIPHERALL}"
     update_config_var $ZBX_CONFIG "TLSCipherAll13" "${ZBX_TLSCIPHERALL13}"
     update_config_var $ZBX_CONFIG "TLSCipherCert" "${ZBX_TLSCIPHERCERT}"
     update_config_var $ZBX_CONFIG "TLSCipherCert13" "${ZBX_TLSCIPHERCERT13}"
     update_config_var $ZBX_CONFIG "TLSCipherPSK" "${ZBX_TLSCIPHERPSK}"
     update_config_var $ZBX_CONFIG "TLSCipherPSK13" "${ZBX_TLSCIPHERPSK13}"
-    update_config_var $ZBX_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}" "${ZBX_TLSKEY}"
 
     update_config_var $ZBX_CONFIG "TLSPSKIdentity" "${ZBX_TLSPSKIDENTITY}"
-    update_config_var $ZBX_CONFIG "TLSPSKFile" "${ZBX_TLSPSKFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSPSKFile" "${ZBX_TLSPSKFILE}" "${ZBX_TLSPSK}"
 
     if [ "$(id -u)" != '0' ]; then
         update_config_var $ZBX_CONFIG "User" "$(whoami)"
diff --git a/Dockerfiles/proxy-sqlite3/README.md b/Dockerfiles/proxy-sqlite3/README.md
index 7ab4fa5fb..cb8aac994 100644
--- a/Dockerfiles/proxy-sqlite3/README.md
+++ b/Dockerfiles/proxy-sqlite3/README.md
@@ -174,13 +174,18 @@ ZBX_LOGSLOWQUERIES=3000
 ZBX_TLSCONNECT=unencrypted
 ZBX_TLSACCEPT=unencrypted
 ZBX_TLSCAFILE=
+ZBX_TLSCA=
 ZBX_TLSCRLFILE=
+ZBX_TLSCRL=
 ZBX_TLSSERVERCERTISSUER=
 ZBX_TLSSERVERCERTSUBJECT=
 ZBX_TLSCERTFILE=
+ZBX_TLSCERT=
 ZBX_TLSKEYFILE=
+ZBX_TLSKEY=
 ZBX_TLSPSKIDENTITY=
 ZBX_TLSPSKFILE=
+ZBX_TLSPSK=
 ZBX_TLSCIPHERALL= # Available since 4.4.7
 ZBX_TLSCIPHERALL13= # Available since 4.4.7
 ZBX_TLSCIPHERCERT= # Available since 4.4.7
@@ -211,7 +216,7 @@ The volume allows load additional modules and extend Zabbix proxy using ``LoadMo
 
 ### ``/var/lib/zabbix/enc``
 
-The volume is used to store TLS related files. These file names are specified using ``ZBX_TLSCAFILE``, ``ZBX_TLSCRLFILE``, ``ZBX_TLSKEY_FILE`` and ``ZBX_TLSPSKFILE`` variables.
+The volume is used to store TLS related files. These file names are specified using ``ZBX_TLSCAFILE``, ``ZBX_TLSCRLFILE``, ``ZBX_TLSCERTFILE``, ``ZBX_TLSKEYFILE`` and ``ZBX_TLSPSKFILE`` variables. Additionally it is possible to use environment variables ``ZBX_TLSCA``, ``ZBX_TLSCRL``, ``ZBX_TLSCERT``, ``ZBX_TLSKEY`` and ``ZBX_TLSPSK`` with plaintext values.
 
 ### ``/var/lib/zabbix/ssh_keys``
 
diff --git a/Dockerfiles/proxy-sqlite3/alpine/Dockerfile b/Dockerfiles/proxy-sqlite3/alpine/Dockerfile
index 221ecaaa7..69e119232 100644
--- a/Dockerfiles/proxy-sqlite3/alpine/Dockerfile
+++ b/Dockerfiles/proxy-sqlite3/alpine/Dockerfile
@@ -72,6 +72,7 @@ RUN set -eux && \
     mkdir -p /var/lib/zabbix && \
     mkdir -p /var/lib/zabbix/db_data && \
     mkdir -p /var/lib/zabbix/enc && \
+    mkdir -p /var/lib/zabbix/enc_internal && \
     mkdir -p /usr/lib/zabbix/externalscripts && \
     mkdir -p /var/lib/zabbix/mibs && \
     mkdir -p /var/lib/zabbix/modules && \
diff --git a/Dockerfiles/proxy-sqlite3/alpine/docker-entrypoint.sh b/Dockerfiles/proxy-sqlite3/alpine/docker-entrypoint.sh
index cb9977ea5..1c06a57be 100755
--- a/Dockerfiles/proxy-sqlite3/alpine/docker-entrypoint.sh
+++ b/Dockerfiles/proxy-sqlite3/alpine/docker-entrypoint.sh
@@ -19,6 +19,8 @@ fi
 ZABBIX_USER_HOME_DIR="/var/lib/zabbix"
 # Configuration files directory
 ZABBIX_ETC_DIR="/etc/zabbix"
+# Internal directory for TLS related files, used when TLS*File specified as plain text values
+ZABBIX_INTERNAL_ENC_DIR="${ZABBIX_USER_HOME_DIR}/enc_internal"
 
 escape_spec_char() {
     local var_value=$1
@@ -108,6 +110,19 @@ update_config_multiple_var() {
     done
 }
 
+file_process_from_env() {
+    local config_path=$1
+    local var_name=$2
+    local file_name=$3
+    local var_value=$4
+
+    if [ ! -z "$var_value" ]; then
+        echo -n "$var_value" > "${ZABBIX_INTERNAL_ENC_DIR}/$var_name"
+        file_name="${ZABBIX_INTERNAL_ENC_DIR}/${var_name}"
+    fi
+    update_config_var $config_path "$var_name" "$file_name"
+}
+
 update_zbx_config() {
     echo "** Preparing Zabbix proxy configuration file"
 
@@ -225,22 +240,22 @@ update_zbx_config() {
 
     update_config_var $ZBX_CONFIG "TLSConnect" "${ZBX_TLSCONNECT}"
     update_config_var $ZBX_CONFIG "TLSAccept" "${ZBX_TLSACCEPT}"
-    update_config_var $ZBX_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}"
-    update_config_var $ZBX_CONFIG "TLSCRLFile" "${ZBX_TLSCRLFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}" "${ZBX_TLSCA}"
+    file_process_from_env $ZBX_CONFIG "TLSCRLFile" "${ZBX_TLSCRLFILE}" "${ZBX_TLSCRL}"
     update_config_var $ZBX_CONFIG "TLSServerCertIssuer" "${ZBX_TLSSERVERCERTISSUER}"
     update_config_var $ZBX_CONFIG "TLSServerCertSubject" "${ZBX_TLSSERVERCERTSUBJECT}"
 
-    update_config_var $ZBX_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}" "${ZBX_TLSCERT}"
     update_config_var $ZBX_CONFIG "TLSCipherAll" "${ZBX_TLSCIPHERALL}"
     update_config_var $ZBX_CONFIG "TLSCipherAll13" "${ZBX_TLSCIPHERALL13}"
     update_config_var $ZBX_CONFIG "TLSCipherCert" "${ZBX_TLSCIPHERCERT}"
     update_config_var $ZBX_CONFIG "TLSCipherCert13" "${ZBX_TLSCIPHERCERT13}"
     update_config_var $ZBX_CONFIG "TLSCipherPSK" "${ZBX_TLSCIPHERPSK}"
     update_config_var $ZBX_CONFIG "TLSCipherPSK13" "${ZBX_TLSCIPHERPSK13}"
-    update_config_var $ZBX_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}" "${ZBX_TLSKEY}"
 
     update_config_var $ZBX_CONFIG "TLSPSKIdentity" "${ZBX_TLSPSKIDENTITY}"
-    update_config_var $ZBX_CONFIG "TLSPSKFile" "${ZBX_TLSPSKFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSPSKFile" "${ZBX_TLSPSKFILE}" "${ZBX_TLSPSK}"
 
     if [ "$(id -u)" != '0' ]; then
         update_config_var $ZBX_CONFIG "User" "$(whoami)"
diff --git a/Dockerfiles/proxy-sqlite3/centos/Dockerfile b/Dockerfiles/proxy-sqlite3/centos/Dockerfile
index 19d7c1bc0..422a35831 100644
--- a/Dockerfiles/proxy-sqlite3/centos/Dockerfile
+++ b/Dockerfiles/proxy-sqlite3/centos/Dockerfile
@@ -76,6 +76,7 @@ RUN --mount=type=tmpfs,target=/var/lib/dnf/ \
     mkdir -p /var/lib/zabbix && \
     mkdir -p /var/lib/zabbix/db_data && \
     mkdir -p /var/lib/zabbix/enc && \
+    mkdir -p /var/lib/zabbix/enc_internal && \
     mkdir -p /usr/lib/zabbix/externalscripts && \
     mkdir -p /var/lib/zabbix/mibs && \
     mkdir -p /var/lib/zabbix/modules && \
diff --git a/Dockerfiles/proxy-sqlite3/centos/docker-entrypoint.sh b/Dockerfiles/proxy-sqlite3/centos/docker-entrypoint.sh
index cb9977ea5..1c06a57be 100755
--- a/Dockerfiles/proxy-sqlite3/centos/docker-entrypoint.sh
+++ b/Dockerfiles/proxy-sqlite3/centos/docker-entrypoint.sh
@@ -19,6 +19,8 @@ fi
 ZABBIX_USER_HOME_DIR="/var/lib/zabbix"
 # Configuration files directory
 ZABBIX_ETC_DIR="/etc/zabbix"
+# Internal directory for TLS related files, used when TLS*File specified as plain text values
+ZABBIX_INTERNAL_ENC_DIR="${ZABBIX_USER_HOME_DIR}/enc_internal"
 
 escape_spec_char() {
     local var_value=$1
@@ -108,6 +110,19 @@ update_config_multiple_var() {
     done
 }
 
+file_process_from_env() {
+    local config_path=$1
+    local var_name=$2
+    local file_name=$3
+    local var_value=$4
+
+    if [ ! -z "$var_value" ]; then
+        echo -n "$var_value" > "${ZABBIX_INTERNAL_ENC_DIR}/$var_name"
+        file_name="${ZABBIX_INTERNAL_ENC_DIR}/${var_name}"
+    fi
+    update_config_var $config_path "$var_name" "$file_name"
+}
+
 update_zbx_config() {
     echo "** Preparing Zabbix proxy configuration file"
 
@@ -225,22 +240,22 @@ update_zbx_config() {
 
     update_config_var $ZBX_CONFIG "TLSConnect" "${ZBX_TLSCONNECT}"
     update_config_var $ZBX_CONFIG "TLSAccept" "${ZBX_TLSACCEPT}"
-    update_config_var $ZBX_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}"
-    update_config_var $ZBX_CONFIG "TLSCRLFile" "${ZBX_TLSCRLFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}" "${ZBX_TLSCA}"
+    file_process_from_env $ZBX_CONFIG "TLSCRLFile" "${ZBX_TLSCRLFILE}" "${ZBX_TLSCRL}"
     update_config_var $ZBX_CONFIG "TLSServerCertIssuer" "${ZBX_TLSSERVERCERTISSUER}"
     update_config_var $ZBX_CONFIG "TLSServerCertSubject" "${ZBX_TLSSERVERCERTSUBJECT}"
 
-    update_config_var $ZBX_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}" "${ZBX_TLSCERT}"
     update_config_var $ZBX_CONFIG "TLSCipherAll" "${ZBX_TLSCIPHERALL}"
     update_config_var $ZBX_CONFIG "TLSCipherAll13" "${ZBX_TLSCIPHERALL13}"
     update_config_var $ZBX_CONFIG "TLSCipherCert" "${ZBX_TLSCIPHERCERT}"
     update_config_var $ZBX_CONFIG "TLSCipherCert13" "${ZBX_TLSCIPHERCERT13}"
     update_config_var $ZBX_CONFIG "TLSCipherPSK" "${ZBX_TLSCIPHERPSK}"
     update_config_var $ZBX_CONFIG "TLSCipherPSK13" "${ZBX_TLSCIPHERPSK13}"
-    update_config_var $ZBX_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}" "${ZBX_TLSKEY}"
 
     update_config_var $ZBX_CONFIG "TLSPSKIdentity" "${ZBX_TLSPSKIDENTITY}"
-    update_config_var $ZBX_CONFIG "TLSPSKFile" "${ZBX_TLSPSKFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSPSKFile" "${ZBX_TLSPSKFILE}" "${ZBX_TLSPSK}"
 
     if [ "$(id -u)" != '0' ]; then
         update_config_var $ZBX_CONFIG "User" "$(whoami)"
diff --git a/Dockerfiles/proxy-sqlite3/ol/Dockerfile b/Dockerfiles/proxy-sqlite3/ol/Dockerfile
index e477d2b20..19e396af0 100644
--- a/Dockerfiles/proxy-sqlite3/ol/Dockerfile
+++ b/Dockerfiles/proxy-sqlite3/ol/Dockerfile
@@ -78,6 +78,7 @@ RUN --mount=type=tmpfs,target=/var/lib/dnf/ \
     mkdir -p /var/lib/zabbix && \
     mkdir -p /var/lib/zabbix/db_data && \
     mkdir -p /var/lib/zabbix/enc && \
+    mkdir -p /var/lib/zabbix/enc_internal && \
     mkdir -p /usr/lib/zabbix/externalscripts && \
     mkdir -p /var/lib/zabbix/mibs && \
     mkdir -p /var/lib/zabbix/modules && \
diff --git a/Dockerfiles/proxy-sqlite3/ol/docker-entrypoint.sh b/Dockerfiles/proxy-sqlite3/ol/docker-entrypoint.sh
index cb9977ea5..1c06a57be 100755
--- a/Dockerfiles/proxy-sqlite3/ol/docker-entrypoint.sh
+++ b/Dockerfiles/proxy-sqlite3/ol/docker-entrypoint.sh
@@ -19,6 +19,8 @@ fi
 ZABBIX_USER_HOME_DIR="/var/lib/zabbix"
 # Configuration files directory
 ZABBIX_ETC_DIR="/etc/zabbix"
+# Internal directory for TLS related files, used when TLS*File specified as plain text values
+ZABBIX_INTERNAL_ENC_DIR="${ZABBIX_USER_HOME_DIR}/enc_internal"
 
 escape_spec_char() {
     local var_value=$1
@@ -108,6 +110,19 @@ update_config_multiple_var() {
     done
 }
 
+file_process_from_env() {
+    local config_path=$1
+    local var_name=$2
+    local file_name=$3
+    local var_value=$4
+
+    if [ ! -z "$var_value" ]; then
+        echo -n "$var_value" > "${ZABBIX_INTERNAL_ENC_DIR}/$var_name"
+        file_name="${ZABBIX_INTERNAL_ENC_DIR}/${var_name}"
+    fi
+    update_config_var $config_path "$var_name" "$file_name"
+}
+
 update_zbx_config() {
     echo "** Preparing Zabbix proxy configuration file"
 
@@ -225,22 +240,22 @@ update_zbx_config() {
 
     update_config_var $ZBX_CONFIG "TLSConnect" "${ZBX_TLSCONNECT}"
     update_config_var $ZBX_CONFIG "TLSAccept" "${ZBX_TLSACCEPT}"
-    update_config_var $ZBX_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}"
-    update_config_var $ZBX_CONFIG "TLSCRLFile" "${ZBX_TLSCRLFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}" "${ZBX_TLSCA}"
+    file_process_from_env $ZBX_CONFIG "TLSCRLFile" "${ZBX_TLSCRLFILE}" "${ZBX_TLSCRL}"
     update_config_var $ZBX_CONFIG "TLSServerCertIssuer" "${ZBX_TLSSERVERCERTISSUER}"
     update_config_var $ZBX_CONFIG "TLSServerCertSubject" "${ZBX_TLSSERVERCERTSUBJECT}"
 
-    update_config_var $ZBX_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}" "${ZBX_TLSCERT}"
     update_config_var $ZBX_CONFIG "TLSCipherAll" "${ZBX_TLSCIPHERALL}"
     update_config_var $ZBX_CONFIG "TLSCipherAll13" "${ZBX_TLSCIPHERALL13}"
     update_config_var $ZBX_CONFIG "TLSCipherCert" "${ZBX_TLSCIPHERCERT}"
     update_config_var $ZBX_CONFIG "TLSCipherCert13" "${ZBX_TLSCIPHERCERT13}"
     update_config_var $ZBX_CONFIG "TLSCipherPSK" "${ZBX_TLSCIPHERPSK}"
     update_config_var $ZBX_CONFIG "TLSCipherPSK13" "${ZBX_TLSCIPHERPSK13}"
-    update_config_var $ZBX_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}" "${ZBX_TLSKEY}"
 
     update_config_var $ZBX_CONFIG "TLSPSKIdentity" "${ZBX_TLSPSKIDENTITY}"
-    update_config_var $ZBX_CONFIG "TLSPSKFile" "${ZBX_TLSPSKFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSPSKFile" "${ZBX_TLSPSKFILE}" "${ZBX_TLSPSK}"
 
     if [ "$(id -u)" != '0' ]; then
         update_config_var $ZBX_CONFIG "User" "$(whoami)"
diff --git a/Dockerfiles/proxy-sqlite3/rhel/Dockerfile b/Dockerfiles/proxy-sqlite3/rhel/Dockerfile
index d1955bae5..b6dda76f2 100644
--- a/Dockerfiles/proxy-sqlite3/rhel/Dockerfile
+++ b/Dockerfiles/proxy-sqlite3/rhel/Dockerfile
@@ -109,6 +109,7 @@ RUN --mount=type=tmpfs,target=/var/lib/dnf/ \
     mkdir -p /var/lib/zabbix && \
     mkdir -p /var/lib/zabbix/db_data && \
     mkdir -p /var/lib/zabbix/enc && \
+    mkdir -p /var/lib/zabbix/enc_internal && \
     mkdir -p /usr/lib/zabbix/externalscripts && \
     mkdir -p /var/lib/zabbix/mibs && \
     mkdir -p /var/lib/zabbix/modules && \
diff --git a/Dockerfiles/proxy-sqlite3/rhel/docker-entrypoint.sh b/Dockerfiles/proxy-sqlite3/rhel/docker-entrypoint.sh
index cb9977ea5..1c06a57be 100755
--- a/Dockerfiles/proxy-sqlite3/rhel/docker-entrypoint.sh
+++ b/Dockerfiles/proxy-sqlite3/rhel/docker-entrypoint.sh
@@ -19,6 +19,8 @@ fi
 ZABBIX_USER_HOME_DIR="/var/lib/zabbix"
 # Configuration files directory
 ZABBIX_ETC_DIR="/etc/zabbix"
+# Internal directory for TLS related files, used when TLS*File specified as plain text values
+ZABBIX_INTERNAL_ENC_DIR="${ZABBIX_USER_HOME_DIR}/enc_internal"
 
 escape_spec_char() {
     local var_value=$1
@@ -108,6 +110,19 @@ update_config_multiple_var() {
     done
 }
 
+file_process_from_env() {
+    local config_path=$1
+    local var_name=$2
+    local file_name=$3
+    local var_value=$4
+
+    if [ ! -z "$var_value" ]; then
+        echo -n "$var_value" > "${ZABBIX_INTERNAL_ENC_DIR}/$var_name"
+        file_name="${ZABBIX_INTERNAL_ENC_DIR}/${var_name}"
+    fi
+    update_config_var $config_path "$var_name" "$file_name"
+}
+
 update_zbx_config() {
     echo "** Preparing Zabbix proxy configuration file"
 
@@ -225,22 +240,22 @@ update_zbx_config() {
 
     update_config_var $ZBX_CONFIG "TLSConnect" "${ZBX_TLSCONNECT}"
     update_config_var $ZBX_CONFIG "TLSAccept" "${ZBX_TLSACCEPT}"
-    update_config_var $ZBX_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}"
-    update_config_var $ZBX_CONFIG "TLSCRLFile" "${ZBX_TLSCRLFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}" "${ZBX_TLSCA}"
+    file_process_from_env $ZBX_CONFIG "TLSCRLFile" "${ZBX_TLSCRLFILE}" "${ZBX_TLSCRL}"
     update_config_var $ZBX_CONFIG "TLSServerCertIssuer" "${ZBX_TLSSERVERCERTISSUER}"
     update_config_var $ZBX_CONFIG "TLSServerCertSubject" "${ZBX_TLSSERVERCERTSUBJECT}"
 
-    update_config_var $ZBX_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}" "${ZBX_TLSCERT}"
     update_config_var $ZBX_CONFIG "TLSCipherAll" "${ZBX_TLSCIPHERALL}"
     update_config_var $ZBX_CONFIG "TLSCipherAll13" "${ZBX_TLSCIPHERALL13}"
     update_config_var $ZBX_CONFIG "TLSCipherCert" "${ZBX_TLSCIPHERCERT}"
     update_config_var $ZBX_CONFIG "TLSCipherCert13" "${ZBX_TLSCIPHERCERT13}"
     update_config_var $ZBX_CONFIG "TLSCipherPSK" "${ZBX_TLSCIPHERPSK}"
     update_config_var $ZBX_CONFIG "TLSCipherPSK13" "${ZBX_TLSCIPHERPSK13}"
-    update_config_var $ZBX_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}" "${ZBX_TLSKEY}"
 
     update_config_var $ZBX_CONFIG "TLSPSKIdentity" "${ZBX_TLSPSKIDENTITY}"
-    update_config_var $ZBX_CONFIG "TLSPSKFile" "${ZBX_TLSPSKFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSPSKFile" "${ZBX_TLSPSKFILE}" "${ZBX_TLSPSK}"
 
     if [ "$(id -u)" != '0' ]; then
         update_config_var $ZBX_CONFIG "User" "$(whoami)"
diff --git a/Dockerfiles/proxy-sqlite3/ubuntu/Dockerfile b/Dockerfiles/proxy-sqlite3/ubuntu/Dockerfile
index 15138e9eb..8c40ce839 100644
--- a/Dockerfiles/proxy-sqlite3/ubuntu/Dockerfile
+++ b/Dockerfiles/proxy-sqlite3/ubuntu/Dockerfile
@@ -74,6 +74,7 @@ RUN --mount=type=cache,target=/var/lib/apt/,sharing=locked \
     mkdir -p /var/lib/zabbix && \
     mkdir -p /var/lib/zabbix/db_data && \
     mkdir -p /var/lib/zabbix/enc && \
+    mkdir -p /var/lib/zabbix/enc_internal && \
     mkdir -p /usr/lib/zabbix/externalscripts && \
     mkdir -p /var/lib/zabbix/mibs && \
     mkdir -p /var/lib/zabbix/modules && \
diff --git a/Dockerfiles/proxy-sqlite3/ubuntu/docker-entrypoint.sh b/Dockerfiles/proxy-sqlite3/ubuntu/docker-entrypoint.sh
index f18332699..c192a088f 100755
--- a/Dockerfiles/proxy-sqlite3/ubuntu/docker-entrypoint.sh
+++ b/Dockerfiles/proxy-sqlite3/ubuntu/docker-entrypoint.sh
@@ -19,6 +19,8 @@ fi
 ZABBIX_USER_HOME_DIR="/var/lib/zabbix"
 # Configuration files directory
 ZABBIX_ETC_DIR="/etc/zabbix"
+# Internal directory for TLS related files, used when TLS*File specified as plain text values
+ZABBIX_INTERNAL_ENC_DIR="${ZABBIX_USER_HOME_DIR}/enc_internal"
 
 escape_spec_char() {
     local var_value=$1
@@ -108,6 +110,19 @@ update_config_multiple_var() {
     done
 }
 
+file_process_from_env() {
+    local config_path=$1
+    local var_name=$2
+    local file_name=$3
+    local var_value=$4
+
+    if [ ! -z "$var_value" ]; then
+        echo -n "$var_value" > "${ZABBIX_INTERNAL_ENC_DIR}/$var_name"
+        file_name="${ZABBIX_INTERNAL_ENC_DIR}/${var_name}"
+    fi
+    update_config_var $config_path "$var_name" "$file_name"
+}
+
 update_zbx_config() {
     echo "** Preparing Zabbix proxy configuration file"
 
@@ -225,22 +240,22 @@ update_zbx_config() {
 
     update_config_var $ZBX_CONFIG "TLSConnect" "${ZBX_TLSCONNECT}"
     update_config_var $ZBX_CONFIG "TLSAccept" "${ZBX_TLSACCEPT}"
-    update_config_var $ZBX_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}"
-    update_config_var $ZBX_CONFIG "TLSCRLFile" "${ZBX_TLSCRLFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}" "${ZBX_TLSCA}"
+    file_process_from_env $ZBX_CONFIG "TLSCRLFile" "${ZBX_TLSCRLFILE}" "${ZBX_TLSCRL}"
     update_config_var $ZBX_CONFIG "TLSServerCertIssuer" "${ZBX_TLSSERVERCERTISSUER}"
     update_config_var $ZBX_CONFIG "TLSServerCertSubject" "${ZBX_TLSSERVERCERTSUBJECT}"
 
-    update_config_var $ZBX_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}" "${ZBX_TLSCERT}"
     update_config_var $ZBX_CONFIG "TLSCipherAll" "${ZBX_TLSCIPHERALL}"
     update_config_var $ZBX_CONFIG "TLSCipherAll13" "${ZBX_TLSCIPHERALL13}"
     update_config_var $ZBX_CONFIG "TLSCipherCert" "${ZBX_TLSCIPHERCERT}"
     update_config_var $ZBX_CONFIG "TLSCipherCert13" "${ZBX_TLSCIPHERCERT13}"
     update_config_var $ZBX_CONFIG "TLSCipherPSK" "${ZBX_TLSCIPHERPSK}"
     update_config_var $ZBX_CONFIG "TLSCipherPSK13" "${ZBX_TLSCIPHERPSK13}"
-    update_config_var $ZBX_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}" "${ZBX_TLSKEY}"
 
     update_config_var $ZBX_CONFIG "TLSPSKIdentity" "${ZBX_TLSPSKIDENTITY}"
-    update_config_var $ZBX_CONFIG "TLSPSKFile" "${ZBX_TLSPSKFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSPSKFile" "${ZBX_TLSPSKFILE}" "${ZBX_TLSPSK}"
 
     if [ "$(id -u)" != '0' ]; then
         update_config_var $ZBX_CONFIG "User" "$(whoami)"
diff --git a/Dockerfiles/server-mysql/README.md b/Dockerfiles/server-mysql/README.md
index eb3065df4..817dc540f 100644
--- a/Dockerfiles/server-mysql/README.md
+++ b/Dockerfiles/server-mysql/README.md
@@ -206,9 +206,13 @@ ZBX_STARTPROXYPOLLERS=1
 ZBX_PROXYCONFIGFREQUENCY=3600
 ZBX_PROXYDATAFREQUENCY=1
 ZBX_TLSCAFILE=
+ZBX_TLSCA=
 ZBX_TLSCRLFILE=
+ZBX_TLSCRL=
 ZBX_TLSCERTFILE=
+ZBX_TLSCERT=
 ZBX_TLSKEYFILE=
+ZBX_TLSKEY=
 ZBX_TLSCIPHERALL= # Available since 4.4.7
 ZBX_TLSCIPHERALL13= # Available since 4.4.7
 ZBX_TLSCIPHERCERT= # Available since 4.4.7
@@ -240,7 +244,7 @@ The volume allows load additional modules and extend Zabbix server using ``LoadM
 
 ### ``/var/lib/zabbix/enc``
 
-The volume is used to store TLS related files. These file names are specified using ``ZBX_TLSCAFILE``, ``ZBX_TLSCRLFILE``, ``ZBX_TLSKEY_FILE`` and ``ZBX_TLSPSKFILE`` variables.
+The volume is used to store TLS related files. These file names are specified using ``ZBX_TLSCAFILE``, ``ZBX_TLSCRLFILE``, ``ZBX_TLSCERTFILE`` and ``ZBX_TLSKEYFILE`` variables. Additionally it is possible to use environment variables ``ZBX_TLSCA``, ``ZBX_TLSCRL``, ``ZBX_TLSCERT`` and ``ZBX_TLSKEY`` with plaintext values.
 
 ### ``/var/lib/zabbix/ssh_keys``
 
diff --git a/Dockerfiles/server-mysql/alpine/Dockerfile b/Dockerfiles/server-mysql/alpine/Dockerfile
index 023740648..db3f20b2e 100644
--- a/Dockerfiles/server-mysql/alpine/Dockerfile
+++ b/Dockerfiles/server-mysql/alpine/Dockerfile
@@ -78,6 +78,7 @@ RUN set -eux && \
     mkdir -p /usr/lib/zabbix/alertscripts && \
     mkdir -p /usr/lib/zabbix/dbscripts && \
     mkdir -p /var/lib/zabbix/enc && \
+    mkdir -p /var/lib/zabbix/enc_internal && \
     mkdir -p /var/lib/zabbix/export && \
     mkdir -p /usr/lib/zabbix/externalscripts && \
     mkdir -p /var/lib/zabbix/mibs && \
diff --git a/Dockerfiles/server-mysql/alpine/docker-entrypoint.sh b/Dockerfiles/server-mysql/alpine/docker-entrypoint.sh
index 8b960210b..37e5c6e2d 100755
--- a/Dockerfiles/server-mysql/alpine/docker-entrypoint.sh
+++ b/Dockerfiles/server-mysql/alpine/docker-entrypoint.sh
@@ -14,6 +14,8 @@ fi
 ZABBIX_USER_HOME_DIR="/var/lib/zabbix"
 # Configuration files directory
 ZABBIX_ETC_DIR="/etc/zabbix"
+# Internal directory for TLS related files, used when TLS*File specified as plain text values
+ZABBIX_INTERNAL_ENC_DIR="${ZABBIX_USER_HOME_DIR}/enc_internal"
 
 : ${DB_CHARACTER_SET:="utf8"}
 : ${DB_CHARACTER_COLLATE:="utf8_bin"}
@@ -137,6 +139,19 @@ update_config_multiple_var() {
     done
 }
 
+file_process_from_env() {
+    local config_path=$1
+    local var_name=$2
+    local file_name=$3
+    local var_value=$4
+
+    if [ ! -z "$var_value" ]; then
+        echo -n "$var_value" > "${ZABBIX_INTERNAL_ENC_DIR}/$var_name"
+        file_name="${ZABBIX_INTERNAL_ENC_DIR}/${var_name}"
+    fi
+    update_config_var $config_path "$var_name" "$file_name"
+}
+
 # Check prerequisites for MySQL database
 check_variables_mysql() {
     if [ ! -n "${DB_SERVER_SOCKET}" ]; then
@@ -473,20 +488,17 @@ update_zbx_config() {
     update_config_var $ZBX_CONFIG "LoadModulePath" "$ZABBIX_USER_HOME_DIR/modules/"
     update_config_multiple_var $ZBX_CONFIG "LoadModule" "${ZBX_LOADMODULE}"
 
-    update_config_var $ZBX_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}"
-    update_config_var $ZBX_CONFIG "TLSCRLFile" "${ZBX_TLSCRLFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}" "${ZBX_TLSCA}"
+    file_process_from_env $ZBX_CONFIG "TLSCRLFile" "${ZBX_TLSCRLFILE}" "${ZBX_TLSCRL}"
 
-    update_config_var $ZBX_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}" "${ZBX_TLSCERT}"
     update_config_var $ZBX_CONFIG "TLSCipherAll" "${ZBX_TLSCIPHERALL}"
     update_config_var $ZBX_CONFIG "TLSCipherAll13" "${ZBX_TLSCIPHERALL13}"
     update_config_var $ZBX_CONFIG "TLSCipherCert" "${ZBX_TLSCIPHERCERT}"
     update_config_var $ZBX_CONFIG "TLSCipherCert13" "${ZBX_TLSCIPHERCERT13}"
     update_config_var $ZBX_CONFIG "TLSCipherPSK" "${ZBX_TLSCIPHERPSK}"
     update_config_var $ZBX_CONFIG "TLSCipherPSK13" "${ZBX_TLSCIPHERPSK13}"
-    update_config_var $ZBX_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}"
-
-    update_config_var $ZBX_CONFIG "TLSPSKIdentity" "${ZBX_TLSPSKIDENTITY}"
-    update_config_var $ZBX_CONFIG "TLSPSKFile" "${ZBX_TLSPSKFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}" "${ZBX_TLSKEY}"
 
     update_config_var $ZBX_CONFIG "SMSDevices" "${ZBX_SMSDEVICES}"
 
diff --git a/Dockerfiles/server-mysql/centos/Dockerfile b/Dockerfiles/server-mysql/centos/Dockerfile
index 4e922d097..08cd8cc4b 100644
--- a/Dockerfiles/server-mysql/centos/Dockerfile
+++ b/Dockerfiles/server-mysql/centos/Dockerfile
@@ -87,6 +87,7 @@ RUN --mount=type=tmpfs,target=/var/lib/dnf/ \
     mkdir -p /usr/lib/zabbix/alertscripts && \
     mkdir -p /usr/lib/zabbix/dbscripts && \
     mkdir -p /var/lib/zabbix/enc && \
+    mkdir -p /var/lib/zabbix/enc_internal && \
     mkdir -p /var/lib/zabbix/export && \
     mkdir -p /usr/lib/zabbix/externalscripts && \
     mkdir -p /var/lib/zabbix/mibs && \
diff --git a/Dockerfiles/server-mysql/centos/docker-entrypoint.sh b/Dockerfiles/server-mysql/centos/docker-entrypoint.sh
index 4459068d9..f4b21d11c 100755
--- a/Dockerfiles/server-mysql/centos/docker-entrypoint.sh
+++ b/Dockerfiles/server-mysql/centos/docker-entrypoint.sh
@@ -14,6 +14,8 @@ fi
 ZABBIX_USER_HOME_DIR="/var/lib/zabbix"
 # Configuration files directory
 ZABBIX_ETC_DIR="/etc/zabbix"
+# Internal directory for TLS related files, used when TLS*File specified as plain text values
+ZABBIX_INTERNAL_ENC_DIR="${ZABBIX_USER_HOME_DIR}/enc_internal"
 
 : ${DB_CHARACTER_SET:="utf8"}
 : ${DB_CHARACTER_COLLATE:="utf8_bin"}
@@ -137,6 +139,19 @@ update_config_multiple_var() {
     done
 }
 
+file_process_from_env() {
+    local config_path=$1
+    local var_name=$2
+    local file_name=$3
+    local var_value=$4
+
+    if [ ! -z "$var_value" ]; then
+        echo -n "$var_value" > "${ZABBIX_INTERNAL_ENC_DIR}/$var_name"
+        file_name="${ZABBIX_INTERNAL_ENC_DIR}/${var_name}"
+    fi
+    update_config_var $config_path "$var_name" "$file_name"
+}
+
 # Check prerequisites for MySQL database
 check_variables_mysql() {
     if [ ! -n "${DB_SERVER_SOCKET}" ]; then
@@ -470,20 +485,17 @@ update_zbx_config() {
     update_config_var $ZBX_CONFIG "LoadModulePath" "$ZABBIX_USER_HOME_DIR/modules/"
     update_config_multiple_var $ZBX_CONFIG "LoadModule" "${ZBX_LOADMODULE}"
 
-    update_config_var $ZBX_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}"
-    update_config_var $ZBX_CONFIG "TLSCRLFile" "${ZBX_TLSCRLFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}" "${ZBX_TLSCA}"
+    file_process_from_env $ZBX_CONFIG "TLSCRLFile" "${ZBX_TLSCRLFILE}" "${ZBX_TLSCRL}"
 
-    update_config_var $ZBX_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}" "${ZBX_TLSCERT}"
     update_config_var $ZBX_CONFIG "TLSCipherAll" "${ZBX_TLSCIPHERALL}"
     update_config_var $ZBX_CONFIG "TLSCipherAll13" "${ZBX_TLSCIPHERALL13}"
     update_config_var $ZBX_CONFIG "TLSCipherCert" "${ZBX_TLSCIPHERCERT}"
     update_config_var $ZBX_CONFIG "TLSCipherCert13" "${ZBX_TLSCIPHERCERT13}"
     update_config_var $ZBX_CONFIG "TLSCipherPSK" "${ZBX_TLSCIPHERPSK}"
     update_config_var $ZBX_CONFIG "TLSCipherPSK13" "${ZBX_TLSCIPHERPSK13}"
-    update_config_var $ZBX_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}"
-
-    update_config_var $ZBX_CONFIG "TLSPSKIdentity" "${ZBX_TLSPSKIDENTITY}"
-    update_config_var $ZBX_CONFIG "TLSPSKFile" "${ZBX_TLSPSKFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}" "${ZBX_TLSKEY}"
 
     update_config_var $ZBX_CONFIG "SMSDevices" "${ZBX_SMSDEVICES}"
 
diff --git a/Dockerfiles/server-mysql/ol/Dockerfile b/Dockerfiles/server-mysql/ol/Dockerfile
index 7fa1bbb80..53137ce7c 100644
--- a/Dockerfiles/server-mysql/ol/Dockerfile
+++ b/Dockerfiles/server-mysql/ol/Dockerfile
@@ -89,6 +89,7 @@ RUN --mount=type=tmpfs,target=/var/lib/dnf/ \
     mkdir -p /usr/lib/zabbix/alertscripts && \
     mkdir -p /var/lib/zabbix/dbscripts && \
     mkdir -p /var/lib/zabbix/enc && \
+    mkdir -p /var/lib/zabbix/enc_internal && \
     mkdir -p /var/lib/zabbix/export && \
     mkdir -p /usr/lib/zabbix/externalscripts && \
     mkdir -p /var/lib/zabbix/mibs && \
diff --git a/Dockerfiles/server-mysql/ol/docker-entrypoint.sh b/Dockerfiles/server-mysql/ol/docker-entrypoint.sh
index 4459068d9..f4b21d11c 100755
--- a/Dockerfiles/server-mysql/ol/docker-entrypoint.sh
+++ b/Dockerfiles/server-mysql/ol/docker-entrypoint.sh
@@ -14,6 +14,8 @@ fi
 ZABBIX_USER_HOME_DIR="/var/lib/zabbix"
 # Configuration files directory
 ZABBIX_ETC_DIR="/etc/zabbix"
+# Internal directory for TLS related files, used when TLS*File specified as plain text values
+ZABBIX_INTERNAL_ENC_DIR="${ZABBIX_USER_HOME_DIR}/enc_internal"
 
 : ${DB_CHARACTER_SET:="utf8"}
 : ${DB_CHARACTER_COLLATE:="utf8_bin"}
@@ -137,6 +139,19 @@ update_config_multiple_var() {
     done
 }
 
+file_process_from_env() {
+    local config_path=$1
+    local var_name=$2
+    local file_name=$3
+    local var_value=$4
+
+    if [ ! -z "$var_value" ]; then
+        echo -n "$var_value" > "${ZABBIX_INTERNAL_ENC_DIR}/$var_name"
+        file_name="${ZABBIX_INTERNAL_ENC_DIR}/${var_name}"
+    fi
+    update_config_var $config_path "$var_name" "$file_name"
+}
+
 # Check prerequisites for MySQL database
 check_variables_mysql() {
     if [ ! -n "${DB_SERVER_SOCKET}" ]; then
@@ -470,20 +485,17 @@ update_zbx_config() {
     update_config_var $ZBX_CONFIG "LoadModulePath" "$ZABBIX_USER_HOME_DIR/modules/"
     update_config_multiple_var $ZBX_CONFIG "LoadModule" "${ZBX_LOADMODULE}"
 
-    update_config_var $ZBX_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}"
-    update_config_var $ZBX_CONFIG "TLSCRLFile" "${ZBX_TLSCRLFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}" "${ZBX_TLSCA}"
+    file_process_from_env $ZBX_CONFIG "TLSCRLFile" "${ZBX_TLSCRLFILE}" "${ZBX_TLSCRL}"
 
-    update_config_var $ZBX_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}" "${ZBX_TLSCERT}"
     update_config_var $ZBX_CONFIG "TLSCipherAll" "${ZBX_TLSCIPHERALL}"
     update_config_var $ZBX_CONFIG "TLSCipherAll13" "${ZBX_TLSCIPHERALL13}"
     update_config_var $ZBX_CONFIG "TLSCipherCert" "${ZBX_TLSCIPHERCERT}"
     update_config_var $ZBX_CONFIG "TLSCipherCert13" "${ZBX_TLSCIPHERCERT13}"
     update_config_var $ZBX_CONFIG "TLSCipherPSK" "${ZBX_TLSCIPHERPSK}"
     update_config_var $ZBX_CONFIG "TLSCipherPSK13" "${ZBX_TLSCIPHERPSK13}"
-    update_config_var $ZBX_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}"
-
-    update_config_var $ZBX_CONFIG "TLSPSKIdentity" "${ZBX_TLSPSKIDENTITY}"
-    update_config_var $ZBX_CONFIG "TLSPSKFile" "${ZBX_TLSPSKFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}" "${ZBX_TLSKEY}"
 
     update_config_var $ZBX_CONFIG "SMSDevices" "${ZBX_SMSDEVICES}"
 
diff --git a/Dockerfiles/server-mysql/rhel/Dockerfile b/Dockerfiles/server-mysql/rhel/Dockerfile
index af1dfb3ae..ece13b551 100644
--- a/Dockerfiles/server-mysql/rhel/Dockerfile
+++ b/Dockerfiles/server-mysql/rhel/Dockerfile
@@ -117,6 +117,7 @@ RUN --mount=type=tmpfs,target=/var/lib/dnf/ \
     mkdir -p /usr/lib/zabbix/alertscripts && \
     mkdir -p /usr/lib/zabbix/dbscripts && \
     mkdir -p /var/lib/zabbix/enc && \
+    mkdir -p /var/lib/zabbix/enc_internal && \
     mkdir -p /var/lib/zabbix/export && \
     mkdir -p /usr/lib/zabbix/externalscripts && \
     mkdir -p /var/lib/zabbix/mibs && \
diff --git a/Dockerfiles/server-mysql/rhel/docker-entrypoint.sh b/Dockerfiles/server-mysql/rhel/docker-entrypoint.sh
index 4459068d9..f4b21d11c 100755
--- a/Dockerfiles/server-mysql/rhel/docker-entrypoint.sh
+++ b/Dockerfiles/server-mysql/rhel/docker-entrypoint.sh
@@ -14,6 +14,8 @@ fi
 ZABBIX_USER_HOME_DIR="/var/lib/zabbix"
 # Configuration files directory
 ZABBIX_ETC_DIR="/etc/zabbix"
+# Internal directory for TLS related files, used when TLS*File specified as plain text values
+ZABBIX_INTERNAL_ENC_DIR="${ZABBIX_USER_HOME_DIR}/enc_internal"
 
 : ${DB_CHARACTER_SET:="utf8"}
 : ${DB_CHARACTER_COLLATE:="utf8_bin"}
@@ -137,6 +139,19 @@ update_config_multiple_var() {
     done
 }
 
+file_process_from_env() {
+    local config_path=$1
+    local var_name=$2
+    local file_name=$3
+    local var_value=$4
+
+    if [ ! -z "$var_value" ]; then
+        echo -n "$var_value" > "${ZABBIX_INTERNAL_ENC_DIR}/$var_name"
+        file_name="${ZABBIX_INTERNAL_ENC_DIR}/${var_name}"
+    fi
+    update_config_var $config_path "$var_name" "$file_name"
+}
+
 # Check prerequisites for MySQL database
 check_variables_mysql() {
     if [ ! -n "${DB_SERVER_SOCKET}" ]; then
@@ -470,20 +485,17 @@ update_zbx_config() {
     update_config_var $ZBX_CONFIG "LoadModulePath" "$ZABBIX_USER_HOME_DIR/modules/"
     update_config_multiple_var $ZBX_CONFIG "LoadModule" "${ZBX_LOADMODULE}"
 
-    update_config_var $ZBX_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}"
-    update_config_var $ZBX_CONFIG "TLSCRLFile" "${ZBX_TLSCRLFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}" "${ZBX_TLSCA}"
+    file_process_from_env $ZBX_CONFIG "TLSCRLFile" "${ZBX_TLSCRLFILE}" "${ZBX_TLSCRL}"
 
-    update_config_var $ZBX_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}" "${ZBX_TLSCERT}"
     update_config_var $ZBX_CONFIG "TLSCipherAll" "${ZBX_TLSCIPHERALL}"
     update_config_var $ZBX_CONFIG "TLSCipherAll13" "${ZBX_TLSCIPHERALL13}"
     update_config_var $ZBX_CONFIG "TLSCipherCert" "${ZBX_TLSCIPHERCERT}"
     update_config_var $ZBX_CONFIG "TLSCipherCert13" "${ZBX_TLSCIPHERCERT13}"
     update_config_var $ZBX_CONFIG "TLSCipherPSK" "${ZBX_TLSCIPHERPSK}"
     update_config_var $ZBX_CONFIG "TLSCipherPSK13" "${ZBX_TLSCIPHERPSK13}"
-    update_config_var $ZBX_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}"
-
-    update_config_var $ZBX_CONFIG "TLSPSKIdentity" "${ZBX_TLSPSKIDENTITY}"
-    update_config_var $ZBX_CONFIG "TLSPSKFile" "${ZBX_TLSPSKFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}" "${ZBX_TLSKEY}"
 
     update_config_var $ZBX_CONFIG "SMSDevices" "${ZBX_SMSDEVICES}"
 
diff --git a/Dockerfiles/server-mysql/ubuntu/Dockerfile b/Dockerfiles/server-mysql/ubuntu/Dockerfile
index 438a4cc72..ebcad1e28 100644
--- a/Dockerfiles/server-mysql/ubuntu/Dockerfile
+++ b/Dockerfiles/server-mysql/ubuntu/Dockerfile
@@ -82,6 +82,7 @@ RUN --mount=type=cache,target=/var/lib/apt/,sharing=locked \
     mkdir -p /usr/lib/zabbix/alertscripts && \
     mkdir -p /usr/lib/zabbix/dbscripts && \
     mkdir -p /var/lib/zabbix/enc && \
+    mkdir -p /var/lib/zabbix/enc_internal && \
     mkdir -p /var/lib/zabbix/export && \
     mkdir -p /usr/lib/zabbix/externalscripts && \
     mkdir -p /var/lib/zabbix/mibs && \
diff --git a/Dockerfiles/server-mysql/ubuntu/docker-entrypoint.sh b/Dockerfiles/server-mysql/ubuntu/docker-entrypoint.sh
index b6c58fd49..97023441c 100755
--- a/Dockerfiles/server-mysql/ubuntu/docker-entrypoint.sh
+++ b/Dockerfiles/server-mysql/ubuntu/docker-entrypoint.sh
@@ -14,6 +14,8 @@ fi
 ZABBIX_USER_HOME_DIR="/var/lib/zabbix"
 # Configuration files directory
 ZABBIX_ETC_DIR="/etc/zabbix"
+# Internal directory for TLS related files, used when TLS*File specified as plain text values
+ZABBIX_INTERNAL_ENC_DIR="${ZABBIX_USER_HOME_DIR}/enc_internal"
 
 : ${DB_CHARACTER_SET:="utf8"}
 : ${DB_CHARACTER_COLLATE:="utf8_bin"}
@@ -137,6 +139,19 @@ update_config_multiple_var() {
     done
 }
 
+file_process_from_env() {
+    local config_path=$1
+    local var_name=$2
+    local file_name=$3
+    local var_value=$4
+
+    if [ ! -z "$var_value" ]; then
+        echo -n "$var_value" > "${ZABBIX_INTERNAL_ENC_DIR}/$var_name"
+        file_name="${ZABBIX_INTERNAL_ENC_DIR}/${var_name}"
+    fi
+    update_config_var $config_path "$var_name" "$file_name"
+}
+
 # Check prerequisites for MySQL database
 check_variables_mysql() {
     if [ ! -n "${DB_SERVER_SOCKET}" ]; then
@@ -470,20 +485,17 @@ update_zbx_config() {
     update_config_var $ZBX_CONFIG "LoadModulePath" "$ZABBIX_USER_HOME_DIR/modules/"
     update_config_multiple_var $ZBX_CONFIG "LoadModule" "${ZBX_LOADMODULE}"
 
-    update_config_var $ZBX_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}"
-    update_config_var $ZBX_CONFIG "TLSCRLFile" "${ZBX_TLSCRLFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}" "${ZBX_TLSCA}"
+    file_process_from_env $ZBX_CONFIG "TLSCRLFile" "${ZBX_TLSCRLFILE}" "${ZBX_TLSCRL}"
 
-    update_config_var $ZBX_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}" "${ZBX_TLSCERT}"
     update_config_var $ZBX_CONFIG "TLSCipherAll" "${ZBX_TLSCIPHERALL}"
     update_config_var $ZBX_CONFIG "TLSCipherAll13" "${ZBX_TLSCIPHERALL13}"
     update_config_var $ZBX_CONFIG "TLSCipherCert" "${ZBX_TLSCIPHERCERT}"
     update_config_var $ZBX_CONFIG "TLSCipherCert13" "${ZBX_TLSCIPHERCERT13}"
     update_config_var $ZBX_CONFIG "TLSCipherPSK" "${ZBX_TLSCIPHERPSK}"
     update_config_var $ZBX_CONFIG "TLSCipherPSK13" "${ZBX_TLSCIPHERPSK13}"
-    update_config_var $ZBX_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}"
-
-    update_config_var $ZBX_CONFIG "TLSPSKIdentity" "${ZBX_TLSPSKIDENTITY}"
-    update_config_var $ZBX_CONFIG "TLSPSKFile" "${ZBX_TLSPSKFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}" "${ZBX_TLSKEY}"
 
     update_config_var $ZBX_CONFIG "SMSDevices" "${ZBX_SMSDEVICES}"
 
diff --git a/Dockerfiles/server-pgsql/README.md b/Dockerfiles/server-pgsql/README.md
index 225597379..10bb186f6 100644
--- a/Dockerfiles/server-pgsql/README.md
+++ b/Dockerfiles/server-pgsql/README.md
@@ -207,9 +207,13 @@ ZBX_STARTPROXYPOLLERS=1
 ZBX_PROXYCONFIGFREQUENCY=3600
 ZBX_PROXYDATAFREQUENCY=1
 ZBX_TLSCAFILE=
+ZBX_TLSCA=
 ZBX_TLSCRLFILE=
+ZBX_TLSCRL=
 ZBX_TLSCERTFILE=
+ZBX_TLSCERT=
 ZBX_TLSKEYFILE=
+ZBX_TLSKEY=
 ZBX_TLSCIPHERALL= # Available since 4.4.7
 ZBX_TLSCIPHERALL13= # Available since 4.4.7
 ZBX_TLSCIPHERCERT= # Available since 4.4.7
@@ -240,7 +244,7 @@ The volume allows load additional modules and extend Zabbix server using ``LoadM
 
 ### ``/var/lib/zabbix/enc``
 
-The volume is used to store TLS related files. These file names are specified using ``ZBX_TLSCAFILE``, ``ZBX_TLSCRLFILE``, ``ZBX_TLSKEY_FILE`` and ``ZBX_TLSPSKFILE`` variables.
+The volume is used to store TLS related files. These file names are specified using ``ZBX_TLSCAFILE``, ``ZBX_TLSCRLFILE``, ``ZBX_TLSCERTFILE`` and ``ZBX_TLSKEYFILE`` variables. Additionally it is possible to use environment variables ``ZBX_TLSCA``, ``ZBX_TLSCRL``, ``ZBX_TLSCERT`` and ``ZBX_TLSKEY`` with plaintext values.
 
 ### ``/var/lib/zabbix/ssh_keys``
 
diff --git a/Dockerfiles/server-pgsql/alpine/Dockerfile b/Dockerfiles/server-pgsql/alpine/Dockerfile
index 65f6a3c77..ada6bd1b9 100644
--- a/Dockerfiles/server-pgsql/alpine/Dockerfile
+++ b/Dockerfiles/server-pgsql/alpine/Dockerfile
@@ -78,6 +78,7 @@ RUN set -eux && \
     mkdir -p /usr/lib/zabbix/alertscripts && \
     mkdir -p /usr/lib/zabbix/dbscripts && \
     mkdir -p /var/lib/zabbix/enc && \
+    mkdir -p /var/lib/zabbix/enc_internal && \
     mkdir -p /var/lib/zabbix/export && \
     mkdir -p /usr/lib/zabbix/externalscripts && \
     mkdir -p /var/lib/zabbix/mibs && \
diff --git a/Dockerfiles/server-pgsql/alpine/docker-entrypoint.sh b/Dockerfiles/server-pgsql/alpine/docker-entrypoint.sh
index 709bf6195..3c97032cf 100755
--- a/Dockerfiles/server-pgsql/alpine/docker-entrypoint.sh
+++ b/Dockerfiles/server-pgsql/alpine/docker-entrypoint.sh
@@ -17,6 +17,8 @@ fi
 ZABBIX_USER_HOME_DIR="/var/lib/zabbix"
 # Configuration files directory
 ZABBIX_ETC_DIR="/etc/zabbix"
+# Internal directory for TLS related files, used when TLS*File specified as plain text values
+ZABBIX_INTERNAL_ENC_DIR="${ZABBIX_USER_HOME_DIR}/enc_internal"
 
 # usage: file_env VAR [DEFAULT]
 # as example: file_env 'MYSQL_PASSWORD' 'zabbix'
@@ -137,6 +139,19 @@ update_config_multiple_var() {
     done
 }
 
+file_process_from_env() {
+    local config_path=$1
+    local var_name=$2
+    local file_name=$3
+    local var_value=$4
+
+    if [ ! -z "$var_value" ]; then
+        echo -n "$var_value" > "${ZABBIX_INTERNAL_ENC_DIR}/$var_name"
+        file_name="${ZABBIX_INTERNAL_ENC_DIR}/${var_name}"
+    fi
+    update_config_var $config_path "$var_name" "$file_name"
+}
+
 # Check prerequisites for PostgreSQL database
 check_variables_postgresql() {
     file_env POSTGRES_USER
@@ -490,20 +505,17 @@ update_zbx_config() {
     update_config_var $ZBX_CONFIG "LoadModulePath" "$ZABBIX_USER_HOME_DIR/modules/"
     update_config_multiple_var $ZBX_CONFIG "LoadModule" "${ZBX_LOADMODULE}"
 
-    update_config_var $ZBX_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}"
-    update_config_var $ZBX_CONFIG "TLSCRLFile" "${ZBX_TLSCRLFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}" "${ZBX_TLSCA}"
+    file_process_from_env $ZBX_CONFIG "TLSCRLFile" "${ZBX_TLSCRLFILE}" "${ZBX_TLSCRL}"
 
-    update_config_var $ZBX_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}" "${ZBX_TLSCERT}"
     update_config_var $ZBX_CONFIG "TLSCipherAll" "${ZBX_TLSCIPHERALL}"
     update_config_var $ZBX_CONFIG "TLSCipherAll13" "${ZBX_TLSCIPHERALL13}"
     update_config_var $ZBX_CONFIG "TLSCipherCert" "${ZBX_TLSCIPHERCERT}"
     update_config_var $ZBX_CONFIG "TLSCipherCert13" "${ZBX_TLSCIPHERCERT13}"
     update_config_var $ZBX_CONFIG "TLSCipherPSK" "${ZBX_TLSCIPHERPSK}"
     update_config_var $ZBX_CONFIG "TLSCipherPSK13" "${ZBX_TLSCIPHERPSK13}"
-    update_config_var $ZBX_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}"
-
-    update_config_var $ZBX_CONFIG "TLSPSKIdentity" "${ZBX_TLSPSKIDENTITY}"
-    update_config_var $ZBX_CONFIG "TLSPSKFile" "${ZBX_TLSPSKFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}" "${ZBX_TLSKEY}"
 
     update_config_var $ZBX_CONFIG "SMSDevices" "${ZBX_SMSDEVICES}"
 
diff --git a/Dockerfiles/server-pgsql/centos/Dockerfile b/Dockerfiles/server-pgsql/centos/Dockerfile
index 03248e3db..603e01ade 100644
--- a/Dockerfiles/server-pgsql/centos/Dockerfile
+++ b/Dockerfiles/server-pgsql/centos/Dockerfile
@@ -86,6 +86,7 @@ RUN --mount=type=tmpfs,target=/var/lib/dnf/ \
     mkdir -p /usr/lib/zabbix/alertscripts && \
     mkdir -p /usr/lib/zabbix/dbscripts && \
     mkdir -p /var/lib/zabbix/enc && \
+    mkdir -p /var/lib/zabbix/enc_internal && \
     mkdir -p /var/lib/zabbix/export && \
     mkdir -p /usr/lib/zabbix/externalscripts && \
     mkdir -p /var/lib/zabbix/mibs && \
diff --git a/Dockerfiles/server-pgsql/centos/docker-entrypoint.sh b/Dockerfiles/server-pgsql/centos/docker-entrypoint.sh
index 709bf6195..3c97032cf 100755
--- a/Dockerfiles/server-pgsql/centos/docker-entrypoint.sh
+++ b/Dockerfiles/server-pgsql/centos/docker-entrypoint.sh
@@ -17,6 +17,8 @@ fi
 ZABBIX_USER_HOME_DIR="/var/lib/zabbix"
 # Configuration files directory
 ZABBIX_ETC_DIR="/etc/zabbix"
+# Internal directory for TLS related files, used when TLS*File specified as plain text values
+ZABBIX_INTERNAL_ENC_DIR="${ZABBIX_USER_HOME_DIR}/enc_internal"
 
 # usage: file_env VAR [DEFAULT]
 # as example: file_env 'MYSQL_PASSWORD' 'zabbix'
@@ -137,6 +139,19 @@ update_config_multiple_var() {
     done
 }
 
+file_process_from_env() {
+    local config_path=$1
+    local var_name=$2
+    local file_name=$3
+    local var_value=$4
+
+    if [ ! -z "$var_value" ]; then
+        echo -n "$var_value" > "${ZABBIX_INTERNAL_ENC_DIR}/$var_name"
+        file_name="${ZABBIX_INTERNAL_ENC_DIR}/${var_name}"
+    fi
+    update_config_var $config_path "$var_name" "$file_name"
+}
+
 # Check prerequisites for PostgreSQL database
 check_variables_postgresql() {
     file_env POSTGRES_USER
@@ -490,20 +505,17 @@ update_zbx_config() {
     update_config_var $ZBX_CONFIG "LoadModulePath" "$ZABBIX_USER_HOME_DIR/modules/"
     update_config_multiple_var $ZBX_CONFIG "LoadModule" "${ZBX_LOADMODULE}"
 
-    update_config_var $ZBX_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}"
-    update_config_var $ZBX_CONFIG "TLSCRLFile" "${ZBX_TLSCRLFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}" "${ZBX_TLSCA}"
+    file_process_from_env $ZBX_CONFIG "TLSCRLFile" "${ZBX_TLSCRLFILE}" "${ZBX_TLSCRL}"
 
-    update_config_var $ZBX_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}" "${ZBX_TLSCERT}"
     update_config_var $ZBX_CONFIG "TLSCipherAll" "${ZBX_TLSCIPHERALL}"
     update_config_var $ZBX_CONFIG "TLSCipherAll13" "${ZBX_TLSCIPHERALL13}"
     update_config_var $ZBX_CONFIG "TLSCipherCert" "${ZBX_TLSCIPHERCERT}"
     update_config_var $ZBX_CONFIG "TLSCipherCert13" "${ZBX_TLSCIPHERCERT13}"
     update_config_var $ZBX_CONFIG "TLSCipherPSK" "${ZBX_TLSCIPHERPSK}"
     update_config_var $ZBX_CONFIG "TLSCipherPSK13" "${ZBX_TLSCIPHERPSK13}"
-    update_config_var $ZBX_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}"
-
-    update_config_var $ZBX_CONFIG "TLSPSKIdentity" "${ZBX_TLSPSKIDENTITY}"
-    update_config_var $ZBX_CONFIG "TLSPSKFile" "${ZBX_TLSPSKFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}" "${ZBX_TLSKEY}"
 
     update_config_var $ZBX_CONFIG "SMSDevices" "${ZBX_SMSDEVICES}"
 
diff --git a/Dockerfiles/server-pgsql/ol/Dockerfile b/Dockerfiles/server-pgsql/ol/Dockerfile
index beb411ea9..14b5aed78 100644
--- a/Dockerfiles/server-pgsql/ol/Dockerfile
+++ b/Dockerfiles/server-pgsql/ol/Dockerfile
@@ -86,6 +86,7 @@ RUN --mount=type=tmpfs,target=/var/lib/dnf/ \
     mkdir -p /usr/lib/zabbix/alertscripts && \
     mkdir -p /usr/lib/zabbix/dbscripts && \
     mkdir -p /var/lib/zabbix/enc && \
+    mkdir -p /var/lib/zabbix/enc_internal && \
     mkdir -p /var/lib/zabbix/export && \
     mkdir -p /usr/lib/zabbix/externalscripts && \
     mkdir -p /var/lib/zabbix/mibs && \
diff --git a/Dockerfiles/server-pgsql/ol/docker-entrypoint.sh b/Dockerfiles/server-pgsql/ol/docker-entrypoint.sh
index 709bf6195..3c97032cf 100755
--- a/Dockerfiles/server-pgsql/ol/docker-entrypoint.sh
+++ b/Dockerfiles/server-pgsql/ol/docker-entrypoint.sh
@@ -17,6 +17,8 @@ fi
 ZABBIX_USER_HOME_DIR="/var/lib/zabbix"
 # Configuration files directory
 ZABBIX_ETC_DIR="/etc/zabbix"
+# Internal directory for TLS related files, used when TLS*File specified as plain text values
+ZABBIX_INTERNAL_ENC_DIR="${ZABBIX_USER_HOME_DIR}/enc_internal"
 
 # usage: file_env VAR [DEFAULT]
 # as example: file_env 'MYSQL_PASSWORD' 'zabbix'
@@ -137,6 +139,19 @@ update_config_multiple_var() {
     done
 }
 
+file_process_from_env() {
+    local config_path=$1
+    local var_name=$2
+    local file_name=$3
+    local var_value=$4
+
+    if [ ! -z "$var_value" ]; then
+        echo -n "$var_value" > "${ZABBIX_INTERNAL_ENC_DIR}/$var_name"
+        file_name="${ZABBIX_INTERNAL_ENC_DIR}/${var_name}"
+    fi
+    update_config_var $config_path "$var_name" "$file_name"
+}
+
 # Check prerequisites for PostgreSQL database
 check_variables_postgresql() {
     file_env POSTGRES_USER
@@ -490,20 +505,17 @@ update_zbx_config() {
     update_config_var $ZBX_CONFIG "LoadModulePath" "$ZABBIX_USER_HOME_DIR/modules/"
     update_config_multiple_var $ZBX_CONFIG "LoadModule" "${ZBX_LOADMODULE}"
 
-    update_config_var $ZBX_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}"
-    update_config_var $ZBX_CONFIG "TLSCRLFile" "${ZBX_TLSCRLFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}" "${ZBX_TLSCA}"
+    file_process_from_env $ZBX_CONFIG "TLSCRLFile" "${ZBX_TLSCRLFILE}" "${ZBX_TLSCRL}"
 
-    update_config_var $ZBX_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}" "${ZBX_TLSCERT}"
     update_config_var $ZBX_CONFIG "TLSCipherAll" "${ZBX_TLSCIPHERALL}"
     update_config_var $ZBX_CONFIG "TLSCipherAll13" "${ZBX_TLSCIPHERALL13}"
     update_config_var $ZBX_CONFIG "TLSCipherCert" "${ZBX_TLSCIPHERCERT}"
     update_config_var $ZBX_CONFIG "TLSCipherCert13" "${ZBX_TLSCIPHERCERT13}"
     update_config_var $ZBX_CONFIG "TLSCipherPSK" "${ZBX_TLSCIPHERPSK}"
     update_config_var $ZBX_CONFIG "TLSCipherPSK13" "${ZBX_TLSCIPHERPSK13}"
-    update_config_var $ZBX_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}"
-
-    update_config_var $ZBX_CONFIG "TLSPSKIdentity" "${ZBX_TLSPSKIDENTITY}"
-    update_config_var $ZBX_CONFIG "TLSPSKFile" "${ZBX_TLSPSKFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}" "${ZBX_TLSKEY}"
 
     update_config_var $ZBX_CONFIG "SMSDevices" "${ZBX_SMSDEVICES}"
 
diff --git a/Dockerfiles/server-pgsql/ubuntu/Dockerfile b/Dockerfiles/server-pgsql/ubuntu/Dockerfile
index d76d51166..3cef90483 100644
--- a/Dockerfiles/server-pgsql/ubuntu/Dockerfile
+++ b/Dockerfiles/server-pgsql/ubuntu/Dockerfile
@@ -82,6 +82,7 @@ RUN --mount=type=cache,target=/var/lib/apt/,sharing=locked \
     mkdir -p /usr/lib/zabbix/alertscripts && \
     mkdir -p /usr/lib/zabbix/dbscripts && \
     mkdir -p /var/lib/zabbix/enc && \
+    mkdir -p /var/lib/zabbix/enc_internal && \
     mkdir -p /var/lib/zabbix/export && \
     mkdir -p /usr/lib/zabbix/externalscripts && \
     mkdir -p /var/lib/zabbix/mibs && \
diff --git a/Dockerfiles/server-pgsql/ubuntu/docker-entrypoint.sh b/Dockerfiles/server-pgsql/ubuntu/docker-entrypoint.sh
index e2970a8cf..16d453a16 100755
--- a/Dockerfiles/server-pgsql/ubuntu/docker-entrypoint.sh
+++ b/Dockerfiles/server-pgsql/ubuntu/docker-entrypoint.sh
@@ -17,6 +17,8 @@ fi
 ZABBIX_USER_HOME_DIR="/var/lib/zabbix"
 # Configuration files directory
 ZABBIX_ETC_DIR="/etc/zabbix"
+# Internal directory for TLS related files, used when TLS*File specified as plain text values
+ZABBIX_INTERNAL_ENC_DIR="${ZABBIX_USER_HOME_DIR}/enc_internal"
 
 # usage: file_env VAR [DEFAULT]
 # as example: file_env 'MYSQL_PASSWORD' 'zabbix'
@@ -137,6 +139,19 @@ update_config_multiple_var() {
     done
 }
 
+file_process_from_env() {
+    local config_path=$1
+    local var_name=$2
+    local file_name=$3
+    local var_value=$4
+
+    if [ ! -z "$var_value" ]; then
+        echo -n "$var_value" > "${ZABBIX_INTERNAL_ENC_DIR}/$var_name"
+        file_name="${ZABBIX_INTERNAL_ENC_DIR}/${var_name}"
+    fi
+    update_config_var $config_path "$var_name" "$file_name"
+}
+
 # Check prerequisites for PostgreSQL database
 check_variables_postgresql() {
     file_env POSTGRES_USER
@@ -490,20 +505,17 @@ update_zbx_config() {
     update_config_var $ZBX_CONFIG "LoadModulePath" "$ZABBIX_USER_HOME_DIR/modules/"
     update_config_multiple_var $ZBX_CONFIG "LoadModule" "${ZBX_LOADMODULE}"
 
-    update_config_var $ZBX_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}"
-    update_config_var $ZBX_CONFIG "TLSCRLFile" "${ZBX_TLSCRLFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSCAFile" "${ZBX_TLSCAFILE}" "${ZBX_TLSCA}"
+    file_process_from_env $ZBX_CONFIG "TLSCRLFile" "${ZBX_TLSCRLFILE}" "${ZBX_TLSCRL}"
 
-    update_config_var $ZBX_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSCertFile" "${ZBX_TLSCERTFILE}" "${ZBX_TLSCERT}"
     update_config_var $ZBX_CONFIG "TLSCipherAll" "${ZBX_TLSCIPHERALL}"
     update_config_var $ZBX_CONFIG "TLSCipherAll13" "${ZBX_TLSCIPHERALL13}"
     update_config_var $ZBX_CONFIG "TLSCipherCert" "${ZBX_TLSCIPHERCERT}"
     update_config_var $ZBX_CONFIG "TLSCipherCert13" "${ZBX_TLSCIPHERCERT13}"
     update_config_var $ZBX_CONFIG "TLSCipherPSK" "${ZBX_TLSCIPHERPSK}"
     update_config_var $ZBX_CONFIG "TLSCipherPSK13" "${ZBX_TLSCIPHERPSK13}"
-    update_config_var $ZBX_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}"
-
-    update_config_var $ZBX_CONFIG "TLSPSKIdentity" "${ZBX_TLSPSKIDENTITY}"
-    update_config_var $ZBX_CONFIG "TLSPSKFile" "${ZBX_TLSPSKFILE}"
+    file_process_from_env $ZBX_CONFIG "TLSKeyFile" "${ZBX_TLSKEYFILE}" "${ZBX_TLSKEY}"
 
     update_config_var $ZBX_CONFIG "SMSDevices" "${ZBX_SMSDEVICES}"
 
diff --git a/env_vars/.env_agent b/env_vars/.env_agent
index 58ecf335e..91698e9eb 100644
--- a/env_vars/.env_agent
+++ b/env_vars/.env_agent
@@ -27,12 +27,17 @@
 # ZBX_TLSCONNECT=unencrypted
 # ZBX_TLSACCEPT=unencrypted
 # ZBX_TLSCAFILE=
+# ZBX_TLSCA=
 # ZBX_TLSCRLFILE=
+# ZBX_TLSCRL=
 # ZBX_TLSSERVERCERTISSUER=
 # ZBX_TLSSERVERCERTSUBJECT=
 # ZBX_TLSCERTFILE=
+# ZBX_TLSCERT=
 # ZBX_TLSKEYFILE=
+# ZBX_TLSKEY=
 # ZBX_TLSPSKIDENTITY=
 # ZBX_TLSPSKFILE=
+# ZBX_TLSPSK=
 # ZBX_DENYKEY=system.run[*]
 # ZBX_ALLOWKEY=
diff --git a/env_vars/.env_prx b/env_vars/.env_prx
index b56d76fed..03c6e21d7 100644
--- a/env_vars/.env_prx
+++ b/env_vars/.env_prx
@@ -47,10 +47,15 @@
 # ZBX_TLSCONNECT=unencrypted
 # ZBX_TLSACCEPT=unencrypted
 # ZBX_TLSCAFILE=
+# ZBX_TLSCA=
 # ZBX_TLSCRLFILE=
+# ZBX_TLSCRL=
 # ZBX_TLSSERVERCERTISSUER=
 # ZBX_TLSSERVERCERTSUBJECT=
 # ZBX_TLSCERTFILE=
+# ZBX_TLSCERT=
 # ZBX_TLSKEYFILE=
+# ZBX_TLSKEY=
 # ZBX_TLSPSKIDENTITY=
 # ZBX_TLSPSKFILE=
+# ZBX_TLSPSK=
diff --git a/env_vars/.env_srv b/env_vars/.env_srv
index eaf288ff9..6fc4b93a2 100644
--- a/env_vars/.env_srv
+++ b/env_vars/.env_srv
@@ -55,6 +55,10 @@ ZBX_ENABLE_SNMP_TRAPS=true
 # ZBX_PROXYDATAFREQUENCY=1
 # ZBX_LOADMODULE="dummy1.so,dummy2.so,dummy10.so"
 # ZBX_TLSCAFILE=
+# ZBX_TLSCA=
 # ZBX_TLSCRLFILE=
+# ZBX_TLSCRL=
 # ZBX_TLSCERTFILE=
+# ZBX_TLSCERT=
 # ZBX_TLSKEYFILE=
+# ZBX_TLSKEY=