diff --git a/crates/nu-command/src/commands/dataframe/mod.rs b/crates/nu-command/src/commands/dataframe/mod.rs
index 85100460e..b0fc5eadb 100644
--- a/crates/nu-command/src/commands/dataframe/mod.rs
+++ b/crates/nu-command/src/commands/dataframe/mod.rs
@@ -79,6 +79,7 @@ pub use series::DataFrameIsUnique;
 pub use series::DataFrameNNull;
 pub use series::DataFrameNUnique;
 pub use series::DataFrameNot;
+pub use series::DataFrameReplace;
 pub use series::DataFrameSeriesRename;
 pub use series::DataFrameSet;
 pub use series::DataFrameSetWithIdx;
diff --git a/crates/nu-command/src/commands/dataframe/series/mod.rs b/crates/nu-command/src/commands/dataframe/series/mod.rs
index d7387be78..7e4309721 100644
--- a/crates/nu-command/src/commands/dataframe/series/mod.rs
+++ b/crates/nu-command/src/commands/dataframe/series/mod.rs
@@ -14,6 +14,7 @@ pub mod n_null;
 pub mod n_unique;
 pub mod not;
 pub mod rename;
+pub mod replace;
 pub mod set;
 pub mod set_with_idx;
 pub mod shift;
@@ -36,6 +37,7 @@ pub use n_null::DataFrame as DataFrameNNull;
 pub use n_unique::DataFrame as DataFrameNUnique;
 pub use not::DataFrame as DataFrameNot;
 pub use rename::DataFrame as DataFrameSeriesRename;
+pub use replace::DataFrame as DataFrameReplace;
 pub use set::DataFrame as DataFrameSet;
 pub use set_with_idx::DataFrame as DataFrameSetWithIdx;
 pub use shift::DataFrame as DataFrameShift;
diff --git a/crates/nu-command/src/commands/dataframe/series/replace.rs b/crates/nu-command/src/commands/dataframe/series/replace.rs
new file mode 100644
index 000000000..b59d957fb
--- /dev/null
+++ b/crates/nu-command/src/commands/dataframe/series/replace.rs
@@ -0,0 +1,72 @@
+use crate::{commands::dataframe::utils::parse_polars_error, prelude::*};
+use nu_engine::WholeStreamCommand;
+use nu_errors::ShellError;
+use nu_protocol::{dataframe::NuSeries, Signature, SyntaxShape};
+use nu_source::Tagged;
+use polars::prelude::IntoSeries;
+
+pub struct DataFrame;
+
+impl WholeStreamCommand for DataFrame {
+    fn name(&self) -> &str {
+        "dataframe replace"
+    }
+
+    fn usage(&self) -> &str {
+        "[Series] Replace the leftmost (sub)string by a regex pattern"
+    }
+
+    fn signature(&self) -> Signature {
+        Signature::build("dataframe replace")
+            .required_named(
+                "pattern",
+                SyntaxShape::String,
+                "Regex pattern to be matched",
+                Some('p'),
+            )
+            .required_named(
+                "replace",
+                SyntaxShape::String,
+                "replacing string",
+                Some('r'),
+            )
+    }
+
+    fn run(&self, args: CommandArgs) -> Result<OutputStream, ShellError> {
+        command(args)
+    }
+
+    fn examples(&self) -> Vec<Example> {
+        vec![Example {
+            description: "Replaces string",
+            example: "[abc abc abc] | dataframe to-series | dataframe replace -p ab -r AB",
+            result: None,
+        }]
+    }
+}
+
+fn command(mut args: CommandArgs) -> Result<OutputStream, ShellError> {
+    let tag = args.call_info.name_tag.clone();
+    let pattern: Tagged<String> = args.req_named("pattern")?;
+    let replace: Tagged<String> = args.req_named("replace")?;
+
+    let series = NuSeries::try_from_stream(&mut args.input, &tag.span)?;
+
+    let chunked = series.as_ref().utf8().map_err(|e| {
+        parse_polars_error::<&str>(
+            &e,
+            &tag.span,
+            Some("The replace command can only be used with string columns"),
+        )
+    })?;
+
+    let res = chunked
+        .as_ref()
+        .replace(pattern.as_str(), replace.as_str())
+        .map_err(|e| parse_polars_error::<&str>(&e, &tag.span, None))?;
+
+    Ok(OutputStream::one(NuSeries::series_to_value(
+        res.into_series(),
+        tag,
+    )))
+}
diff --git a/crates/nu-command/src/commands/mod.rs b/crates/nu-command/src/commands/mod.rs
index f738d5f11..329c3dc50 100644
--- a/crates/nu-command/src/commands/mod.rs
+++ b/crates/nu-command/src/commands/mod.rs
@@ -31,9 +31,9 @@ pub use dataframe::{
     DataFrameFilter, DataFrameFirst, DataFrameGet, DataFrameGroupBy, DataFrameIsDuplicated,
     DataFrameIsIn, DataFrameIsNotNull, DataFrameIsNull, DataFrameIsUnique, DataFrameJoin,
     DataFrameLast, DataFrameList, DataFrameMelt, DataFrameNNull, DataFrameNUnique, DataFrameNot,
-    DataFrameOpen, DataFramePivot, DataFrameSample, DataFrameSelect, DataFrameSeriesRename,
-    DataFrameSet, DataFrameSetWithIdx, DataFrameShape, DataFrameShift, DataFrameShow,
-    DataFrameSlice, DataFrameSort, DataFrameTake, DataFrameToCsv, DataFrameToDF,
+    DataFrameOpen, DataFramePivot, DataFrameReplace, DataFrameSample, DataFrameSelect,
+    DataFrameSeriesRename, DataFrameSet, DataFrameSetWithIdx, DataFrameShape, DataFrameShift,
+    DataFrameShow, DataFrameSlice, DataFrameSort, DataFrameTake, DataFrameToCsv, DataFrameToDF,
     DataFrameToParquet, DataFrameToSeries, DataFrameUnique, DataFrameValueCounts, DataFrameWhere,
     DataFrameWithColumn,
 };
diff --git a/crates/nu-command/src/default_context.rs b/crates/nu-command/src/default_context.rs
index 2f82656d6..7458faefd 100644
--- a/crates/nu-command/src/default_context.rs
+++ b/crates/nu-command/src/default_context.rs
@@ -318,6 +318,7 @@ pub fn create_default_context(interactive: bool) -> Result<EvaluationContext, Bo
             whole_stream_command(DataFrameTake),
             whole_stream_command(DataFrameSetWithIdx),
             whole_stream_command(DataFrameShape),
+            whole_stream_command(DataFrameReplace),
         ]);
 
         #[cfg(feature = "clipboard-cli")]